Rachael Richardson

Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation

Alex C Thompson, Andrew K Wise, William L Hart, Karina Needham, James B Fallon, Niliksha Gunewardene, Paul R Stoddart, Rachael T Richardson

Journal article  |  2020  |  Journal of Neural Engineering

OBJECTIVE: Compared to electrical stimulation, optogenetic stimulation has the potential to improve the spatial precision of neura..

Optical stimulation of neural tissue

Rachael Theresa Richardson, Michael R Ibbotson, Alexander C Thompson, Andrew K Wise, James B Fallon

Journal article  |  2020  |  Health Technology Letters

Electrical stimulation has been used for decades in devices such as pacemakers, cochlear implants and more recently for deep brain..

Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency-an in vitro study

William L Hart, Rachael T Richardson, Tatiana Kameneva, Alex C Thompson, Andrew K Wise, James B Fallon, Paul R Stoddart, Karina Needham

Journal article  |  2020  |  Journal of Neural Engineering

OBJECTIVE: The performance of neuroprostheses, including cochlear and retinal implants, is currently constrained by the spatial re..

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

Journal article  |  2019  |  Biomacromolecules

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..

New molecular therapies for the treatment of hearing loss

Yutian Ma, Andrew K Wise, Robert K Shepherd, Rachael T Richardson

Journal article  |  2019  |  Pharmacology & Therapeutics

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of..

Pharmacokinetics and tissue distribution of neurotrophin 3 after intracochlear delivery

Rachael T Richardson, Qi-Ying Hu, Fuxin Shi, Nguyen Trung, James B Fallon, Brianna O Flynn, Andrew K Wise

Journal article  |  2019  |  Journal of Controlled Release

Distribution and retention of neurotrophin-3 in cochlea

QY Hu, R Richardson, A Wise, R Stewart, J Lee, F Shi

Conference Proceedings  |  2019  |  Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

Journal article  |  2018  |  ACS APPLIED MATERIALS & INTERFACES

Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss

Rachael T Richardson, Alexander C Thompson, Andrew K Wise, Karina Needham

Journal article  |  2017  |  Expert Opinion on Biological Therapy

Atoh1 gene therapy in the cochlea for hair cell regeneration.

Rachael T Richardson, Patrick J Atkinson

Journal article  |  2015  |  Expert Opin Biol Ther

INTRODUCTION: The sensory epithelium of the cochlea is a complex structure containing hair cells, supporting cells and auditory ne..