Dr Rachael Richardson is currently a Principal Research Fellow at the Bionics Institute. The main goal of her research is to develop innovative strategies to improve precision of neural stimulation.
Rachael’s research is examining whether optogenetic-based stimulation strategies can significantly improve the precision of nerve activation in the cochlea and whether this will result in a meaningful difference to the way people hear sound.
Another major focus of Rachael’s research is to protect and/or restore hearing. Rachael is employing gene therapy and nano-technology-inspired drug delivery techniques to introduce therapeutics into the cochlea for sensory cell regeneration and repair. These techniques have the potential to improve the outcomes achieved with cochlear implantation or even restore hearing by repopulating the damaged sensory region of the cochlea with new cells.
Rachael completed a BSc degree at the University of Melbourne. Her BSc(Hons) and PhD were undertaken at the Walter and Eliza Hall Institute of Medical Research, Department of Cancer and Haematology, supervised by Prof Doug Hilton. Rachael has worked at the Bionics Institute since 2001.
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Gene Therapy For Preventing Progressive Sensorineural Hearing Loss And Restoring Hearing
Pharmacokinetics and tissue distribution of neurotrophin 3 after intracochlear delivery
Displaying the 2 most recent projects by Rachael Richardson.
Displaying the 38 most recent scholarly works by Rachael Richardson.
Engineering Biocoatings To Prolong Drug Release from Supraparticles
Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso
Journal article | 2019 | Biomacromolecules
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..
New molecular therapies for the treatment of hearing loss
Yutian Ma, Andrew K Wise, Robert K Shepherd, Rachael T Richardson
Journal article | 2019 | Pharmacology & Therapeutics
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of..
Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery
Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso
Journal article | 2018 | ACS APPLIED MATERIALS & INTERFACES
Impedance changes in chronically implanted and stimulated cochlear implant electrodes.
Carrie Newbold, Silvana Mergen, Rachael Richardson, Peter Seligman, Rodney Millard, Robert Cowan, Robert Shepherd
Journal article | 2014 | Cochlear Implants International
OBJECTIVES: Electrode impedance increases following implantation and undergoes transitory reduction with onset of electrical stimu..
Effects of Localized Neurotrophin Gene Expression on Spiral Ganglion Neuron Resprouting in the Deafened Cochlea
Andrew K Wise, Clifford R Hume, Brianna O Flynn, Yogesh S Jeelall, Courtney L Suhr, Beatrice E Sgro, Stephen J O'Leary, Robert K Shepherd, Rachael T Richardson
Journal article | 2010 | Molecular Therapy
Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole/BDNF-coated electrodes
Alison J Evans, Brianna C Thompson, Gordon G Wallace, Rodney Millard, Stephen J O'Leary, Graeme M Clark, Robert K Shepherd, Rachael T Richardson
Journal article | 2009 | Journal of Biomedical Materials Research Part A
Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons
Rachael T Richardson, Andrew K Wise, Brianna C Thompson, Brianna O Flynn, Patrick J Atkinson, Nicole J Fretwell, James B Fallon, Gordon G Wallace, Rob K Shepherd, Graeme M Clark, Stephen J O'Leary
Journal article | 2009 | BIOMATERIALS
The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons
Rachael T Richardson, Brianna Thompson, Simon Moulton, Carrie Newbold, May Ghee Lum, Adrian Cameron, Gordon Wallace, Robert Kapsa, Graeme Clark, Stephen O'Leary
Journal article | 2007 | BIOMATERIALS
Medical Bionics Department
Medical Bionics Department