Rachael Richardson

Viral-mediated transduction of auditory neurons with opsins for optical and hybrid activation

Rachael T Richardson, Alex C Thompson, Andrew K Wise, Elise A Ajay, Niliksha Gunewardene, Stephen J O'Leary, Paul R Stoddart, James B Fallon

Journal article  |  2021  |  SCIENTIFIC REPORTS

Optical stimulation is a paradigm-shifting approach to modulating neural activity that has the potential to overcome the issue of ..

Hybrid optogenetic and electrical stimulation for greater spatial resolution and temporal fidelity of cochlear activation

Alex C Thompson, Andrew K Wise, William L Hart, Karina Needham, James B Fallon, Niliksha Gunewardene, Paul R Stoddart, Rachael T Richardson

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: Compared to electrical stimulation, optogenetic stimulation has the potential to improve the spatial precision of neura..

Optical stimulation of neural tissue

Rachael Theresa Richardson, Michael R Ibbotson, Alexander C Thompson, Andrew K Wise, James B Fallon

Journal article  |  2020  |  HEALTHCARE TECHNOLOGY LETTERS

Electrical stimulation has been used for decades in devices such as pacemakers, cochlear implants and more recently for deep brain..

Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency-an in vitro study

William L Hart, Rachael T Richardson, Tatiana Kameneva, Alex C Thompson, Andrew K Wise, James B Fallon, Paul R Stoddart, Karina Needham

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: The performance of neuroprostheses, including cochlear and retinal implants, is currently constrained by the spatial re..

A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery

Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Nguyen Trung, Brianna Flynn, Andrew K Wise, Rachael T Richardson

Journal article  |  2020  |  METHODSX

Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery..

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

Journal article  |  2019  |  Biomacromolecules

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..

New molecular therapies for the treatment of hearing loss

Yutian Ma, Andrew K Wise, Robert K Shepherd, Rachael T Richardson

Journal article  |  2019  |  PHARMACOLOGY & THERAPEUTICS

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing loss is characterized by degeneration of..

Pharmacokinetics and tissue distribution of neurotrophin 3 after intracochlear delivery

Rachael T Richardson, Qi-Ying Hu, Fuxin Shi, Nguyen Trung, James B Fallon, Brianna O Flynn, Andrew K Wise

Journal article  |  2019  |  JOURNAL OF CONTROLLED RELEASE

Neurotrophin therapy has potential to reverse some forms of hearing loss. However, cochlear pharmacokinetic studies are challengin..

Distribution and retention of neurotrophin-3 in cochlea

QY Hu, R Richardson, A Wise, R Stewart, J Lee, F Shi

Conference Proceedings  |  2019  |  Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

Journal article  |  2018  |  ACS APPLIED MATERIALS & INTERFACES

Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeut..