Vijaya Kenche

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

Ryan D Mills, Lung-Yu Liang, Daisy Sio-Seng Lio, Yee-Foong Mok, Terrence D Mulhern, George Cao, Michael Griffin, Vijaya B Kenche, Janetta G Culvenor, Heung-Chin Cheng

Journal article  |  2018  |  Journal of Neurochemistry

Copper Exchange and Redox Activity of a Prototypical 8-Hydroxyquinoline: Implications for Therapeutic Chelation

Mariusz Mital, Izabela A Zawisza, Magdalena Z Wiloch, Urszula E Wawrzyniak, Vijaya Kenche, Wojciech Wroblewski, Wojciech Bal, Simon C Drew

Journal article  |  2016  |  Inorganic Chemistry

Synthesis of 2-Pyridyl-benzimidazole Iridium(III), Ruthenium(II), and Platinum(II) Complexes. Study of the Activity as Inhibitors of Amyloid-beta Aggregation and Neurotoxicity Evaluation

Gorakh S Yellol, Jyoti G Yellol, Vijaya B Kenche, Xiang Ming Liu, Kevin J Barnham, Antonio Donaire, Christoph Janiak, Jose Ruiz

Journal article  |  2015  |  Inorganic Chemistry

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

Cyril C Curtain, Nigel M Kirby, Haydyn DT Mertens, Kevin J Barnham, Robert B Knott, Colin L Masters, Roberto Cappai, Agata Rekas, Vijaya B Kenche, Timothy Ryan

Journal article  |  2015  |  MOLECULAR BIOSYSTEMS

Mixed Ligand Cu2 Complexes of a Model Therapeutic with Alzheimer's Amyloid-beta Peptide and Monoamine Neurotransmitters

Vijaya B Kenche, Izabela Zawisza, Colin L Masters, Wojciech Bal, Kevin J Barnham, Simon C Drew

Journal article  |  2013  |  Inorganic Chemistry

Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer's Disease

Vijaya B Kenche, Lin W Hung, Keyla Perez, Irene Volitakes, Guiseppe Ciccotosto, Jeffrey Kwok, Nicole Critch, Nikki Sherratt, Mikhalina Cortes, Varsha Lal, Colin L Masters, Kazuma Murakami, Roberto Cappai, Paul A Adlard, Kevin J Barnham

Journal article  |  2013  |  Angewandte Chemie - International Edition

Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-beta peptide

Victor A Streltsov, V Chandana Epa, Simon A James, Quentin I Churches, Joanne M Caine, Vijaya B Kenche, Kevin J Barnham

Journal article  |  2013  |  Chemical Communications

Utility of an improved model of amyloid-beta (A beta(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny

Journal article  |  2012  |  MOLECULAR NEURODEGENERATION

Near-Infrared Fluorescence Imaging of Apoptotic Neuronal Cell Death in a Live Animal Model of Prion Disease

Victoria A Lawson, Cathryn L Haigh, Blaine Roberts, Vijaya B Kenche, Helen MJ Klemm, Colin L Masters, Steven J Collins, Kevin J Barnham, Simon C Drew

Journal article  |  2010  |  ACS Chemical Neuroscience

Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of alpha-Synuclein in a pH-Dependent Manner

Chi LL Pham, Su Ling Leong, Feda E Ali, Vijaya B Kenche, Andrew F Hill, Sally L Gras, Kevin J Barnham, Roberto Cappai

Journal article  |  2009  |  Journal of Molecular Biology