Simon Murray is a Senior Lecturer and Laboratory Head in the Department of Anatomy and Neuroscience.
He graduated as a Physiotherapist in 1992, worked for several years before returning to study and graduating with his PhD in 2000. He spent 3 years as a post-doctoral fellow at the New York University School of Medicine (Skirball Institute), before returning to Australia to work at the Florey Neuroscience Institutes in the Multiple Sclerosis Research Division.
He moved his laboratory to the Centre for Neuroscience in 2005, and joined the Department of Anatomy and Neuroscience in 2010. His research primarily focuses on myelin biology, in particular understanding the nature of the signals between neurons and glia that regulate normal myelination during development and myelin repair after nervous system injury. He has a particular interest in a family of growth factors known as the neurotrophins, and how neurotrophin-based strategies could be developed to promote myelin repair in the context of demyelinating disease such as multiple sclerosis.
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Simon Murray's highlights
Simon Murray's selected work
Oligodendroglial Expression of TrkB Independently Regulates Myelination and Progenitor Cel..
Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflect..
Displaying the 15 most recent projects by Simon Murray.
Internal Research Grant
Displaying the 61 most recent scholarly works by Simon Murray.
Sex-specific spatial memory deficits in mice with a conditional TrkB deletion on parvalbumin interneurons
Adrienne Mary Grech, Xin Du, Simon S Murray, Junhua Xiao, Rachel Anne Hill
Journal article | 2019 | Behavioural Brain Research
Schizophrenia is a debilitating disorder characterised by three main symptom categories: positive, negative and cognitive. Cogniti..
The effect of TrkB receptor knockdown on mouse retinal ganglion cell function and their response to acute mild intraocular pressure stress
Vickie Hoi Ying Wong, Amy Wang, Christine Tram Oanh Nguyen, Jeremiah Kah Heng Lim, Madeline Nicholson, Junhua Xiao, Simon Murray, Bang V Bui
Conference Proceedings | 2019 | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression
Nadia P Goncalves, Simin Mohseni, Marwa El Soury, Maj Ulrichsen, Mette Richner, Junhua Xiao, Rhiannon J Wood, Olav M Andersen, Elizabeth J Coulson, Stefania Raimondo, Simon S Murray, Christian B Vaegter
Journal article | 2019 | Frontiers in Cellular Neuroscience
Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain
Jessica L Fletcher, Rhiannon J Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa R Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan E Northfield, Richard A Hughes, David G Gonsalvez, Junhua Xiao, Simon S Murray
Journal article | 2018 | The Journal of Neuroscience
BDNF haploinsufficiency exerts a transient and regionally different influence upon oligodendroglial lineage cells during postnatal development
Madeline Nicholson, Rhiannon J Wood, Jessica L Fletcher, Maarten van den Buuse, Simon S Murray, Junhua Xiao
Journal article | 2018 | Molecular and Cellular Neuroscience
A Brain-Derived Neurotrophic Factor-Based p75(NTR) Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination
David G Gonsalvez, Giang Tran, Jessica L Fletcher, Richard A Hughes, Suzanne Hodgkinson, Rhiannon J Wood, Sang Won Yoo, Mithraka De Silva, Wong W Agnes, Catriona McLean, Paul Kennedy, Trevor J Kilpatrick, Simon S Murray, Junhua Xiao
Journal article | 2017 | ENEURO
A Functional and Neuropathological Testing Paradigm Reveals New Disability-Based Parameters and Histological Features for P0(180-190)-Induced Experimental Autoimmune Neuritis in C57BL/6 Mice
David G Gonsalvez, Mithraka De Silva, Rhiannon J Wood, Lauren Giuffrida, Trevor J Kilpatrick, Simon S Murray, Junhua Xiao
Journal article | 2017 | Journal of Neuropathology & Experimental Neurology
BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons
Junhua Xiao, Agnes W Wong, Melanie M Willingham, Selma K Kaasinen, Ian A Hendry, Jason Howitt, Ulrich Putz, Graham L Barrett, Trevor J Kilpatrick, Simon S Murray
Journal article | 2009 | Journal of Neuroscience
Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair
Mark P Marriott, Ben Emery, Holly S Cate, Michele D Binder, Dennis Kemper, Qizhu Wu, Scott Kolbe, Ian R Gordon, Hong Wang, Gary Egan, Simon Murray, Helmut Butzkueven, Trevor J Kilpatrick
Journal article | 2008 | Glia
PTP sigma binds and dephosphorylates neurotrophin receptors and can suppress NGF-dependent neurite outgrowth from sensory neurons
Clare Faux, Muhamed Hawadle, Jennifer Nixon, Adam Wallace, Simon Lee, Simon Murray, Andrew Stoker
Journal article | 2007 | Biochimica et Biophysica Acta - Molecular Cell Research
Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
Ben Emery, Holly S Cate, Mark Marriottt, Tobias Merson, Michele D Binder, Cameron Snell, Pik Ying Soo, Simon Murray, Ben Croker, Jian-Guo Zhang, Warren S Alexander, Helen Cooper, Helmut Butzkueven, Trevor J Kilpatrick
Journal article | 2006 | Proceedings of the National Academy of Sciences of the United States of America
Inhibiting Bone Morphogenetic Protein 4 Type I Receptor Signaling Promotes Remyelination by Potentiating Oligodendrocyte Differentiation.
Alistair E Govier-Cole, Rhiannon J Wood, Jessica L Fletcher, David G Gonsalvez, Daniel Merlo, Holly S Cate, Simon S Murray, Junhua Xiao
Journal article | eneuro
Blocking inhibitory factors within CNS demyelinating lesions is regarded as a promising strategy to promote remyelination. Bone mo..
Honours, Awards and Fellowships
Sir Grafton Elliot Smith Award
Associate Professor - Topographic Anatomy
Anatomy And Neuroscience
Australian Neuroscience Society
Society for Neuroscience
Doctor of Philosophy
Bachelor of Applied Science (Physiotherapy)
La Trobe University
Bachelor of Science, Degree with Honours
University of Melbourne