Justin Tan

Increased susceptibility to acoustic trauma in a mouse model of non-syndromic sensorineural deafness, DFNB91

Justin Tan, Dion Kaiserman, Stephen J O'Leary, Phillip I Bird

Journal article  |  2020  |  EUROPEAN JOURNAL OF NEUROSCIENCE

Inactivating mutations of SERPINB6 in humans result in progressive hearing loss starting in early adulthood (DFNB91). We have prev..

Adjuvant agents enhance round window membrane permeability to dexamethasone and modulate basal to apical cochlear gradients

Nathan J Creber, Hayden T Eastwood, Amy J Hampson, Justin Tan, Stephen J O'Leary

Journal article  |  2019  |  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Glucocorticoids have direct anti-inflammatory, anti-oxidant and anti-apoptotic effects on cochlear hair cells. Cochlear glucocorti..

A comparison of cochlear distribution and glucocorticoid receptor activation in local and systemic dexamethasone drug delivery regimes

Nathan J Creber, Hayden T Eastwood, Amy J Hampson, Justin Tan, Stephen J O'Leary

Journal article  |  2018  |  HEARING RESEARCH

Local and systemically delivered glucocorticoids are commonly administered to protect the cochlea against damage associated with a..

Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd

Journal article  |  2016  |  PLOS ONE

Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf ..

Drug delivery: mesoporous silica supraparticles for sustained inner-ear drug delivery (small 21/2014).

Y Wang, AK Wise, J Tan, JW Maina, RK Shepherd, F Caruso

Journal article  |  2014  |  Small

Mesoporous silica supraparticles (MS-SPs) self-assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caru..

Mesoporous Silica Supraparticles for Sustained Inner-Ear Drug Delivery

Y Wang, JW Maina, F Caruso, AK Wise, RK Shepherd, J Tan

Journal article  |  2014  |  Small

Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force ..

Early Cochlear Response and ICAM-1 Expression to Cochlear Implantation

Gordana Elizabeth Kel, Justin Tan, Hayden Timothy Eastwood, Sarin Wongprasartsuk, Stephen John O'Leary

Journal article  |  2013  |  OTOLOGY & NEUROTOLOGY

AIM: To examine the early cochlear response and intercellular cell adhesion molecule-1 (ICAM-1) expression to implantation of a co..

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

David AX Nayagam, Ceara McGowan, Joel Villalobos, Richard A Williams, Cesar Salinas-LaRosa, Penny McKelvie, Irene Lo, Meri Basa, Justin Tan, Chris E Williams

Journal article  |  2013  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

With the recent development of retinal prostheses, it is important to develop reliable techniques for assessing the safety of thes..

Absence of SERPINB6A Causes Sensorineural Hearing Loss with Multiple Histopathologies in the Mouse Inner Ear

Justin Tan, Monica D Prakash, Dion Kaiserman, Phillip I Bird

Journal article  |  2013  |  AMERICAN JOURNAL OF PATHOLOGY

A homozygous mutation of SERPINB6, a gene encoding an intracellular protease inhibitor, has recently been associated with post-lin..

Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Justin Tan, Yajun Wang, Xiaopei Yip, Fergal Glynn, Robert K Shepherd, Frank Caruso

Journal article  |  2012  |  ADVANCED MATERIALS

Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica tem..