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Jason Lenzo's selected work
Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Po..
Designing antibiotic peptide polymer adjuvants for multidrug resistant bacteria
Displaying the 7 most recent projects by Jason Lenzo.
Internal Research Grant
Displaying the 43 most recent scholarly works by Jason Lenzo.
Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity
Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao
Journal article | 2018 | Advanced Healthcare Materials
Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2
James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca KH Orth, Ashley Mansell, Eric C Reynolds
Journal article | 2017 | Infection and Immunity
Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo
Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, William Singleton, Alexis Perez-Gonzalez, Ashley Mansell, Eric C Reynolds
Journal article | 2017 | Frontiers in Immunology
A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis
Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan, Gail C Brammar, Katrina A Walsh, William Singleton, Rebecca KH Orth, Nada Slakeski, Keith J Cross, Ivan B Darby, Dorit Becher, Tony Rowe, Adriana Baz Morelli, Andrew Hammet, Andrew Nash, Anna Brown, Bing Ma, Didier Vingadassalom, Jacqueline McCluskey, et al.
Journal article | 2016 | npj Vaccines
Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers
Shu J Lam, Neil M O'Brien-Simpson, Namfon Pantarat, Adrian Sulistio, Edgar HH Wong, Yu-Yen Chen, Jason C Lenzo, James A Holden, Anton Blencowe, Eric C Reynolds, Greg G Qiao
Journal article | 2016 | Nature Microbiology
Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens
Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds
Journal article | 2016 | PLOS ONE
Tannerella forsythia Outer Membrane Vesicles Are Enriched with Substrates of the Type IX Secretion System and TonB-Dependent Receptors
Paul D Veith, Yu-Yen Chen, Dina Chen, Neil M O'Brien-Simpson, Jessica D Cecil, James A Holden, Jason C Lenzo, Eric C Reynolds
Journal article | 2015 | Journal of Proteome Research
GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model
Roselind S Lam, Neil M O'Brien-Simpson, John A Hamilton, Jason C Lenzo, James A Holden, Gail C Brammar, Rebecca K Orth, Yan Tan, Katrina A Walsh, Andrew J Fleetwood, Eric C Reynolds
Journal article | 2015 | Immunology and Cell Biology
Macrophage Depletion Abates Porphyromonas gingivalis-Induced Alveolar Bone Resorption in Mice
Roselind S Lam, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Gail C Brammar, Katrina A Walsh, Judith E McNaughtan, Dennis K Rowler, Nico Van Rooijen, Eric C Reynolds
Journal article | 2014 | Journal of Immunology
The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor
Agnieszka Swierczak, Andrew D Cook, Jason C Lenzo, Christina M Restall, Judy P Doherty, Robin L Anderson, John A Hamilton
Journal article | 2014 | Cancer Immunology Research
Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines
Yan Yan, Katelyn T Gause, Marloes MJ Kamphuis, Ching-Seng Ang, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Edouard C Nice, Frank Caruso
Journal article | 2013 | ACS Nano
Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens
Paula T Cunningham, Claire E Elliot, Jason C Lenzo, Andrew G Jarnicki, Alexander N Larcombe, Graeme R Zosky, Patrick G Holt, Wayne R Thomas
Journal article | 2012 | International Archives of Allergy and Immunology
BACKGROUND: Innate properties that enhance immune responses might increase the propensity of certain allergens to induce allergic ..
Regulation of Systemic and Local Myeloid Cell Subpopulations by Bone Marrow Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor in Experimental Inflammatory Arthritis
Andrew D Cook, Amanda L Turner, Emma L Braine, Jarrad Pobjoy, Jason C Lenzo, John A Hamilton
Journal article | 2011 | Arthritis and Rheumatism
Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
Andrew D Cook, Christine M De Nardo, Emma L Braine, Amanda L Turner, Ross Vlahos, Kerrie J Way, S Kaye Beckman, Jason C Lenzo, John A Hamilton
Journal article | 2010 | Arthritis Research & Therapy
Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigen
Jacqueline P McGlade, Shelley Gorman, Jason C Lenzo, Jamie W Tan, Takeshi Watanabe, John J Finlay-Jones, Wayne R Thomas, Prue H Hart
Journal article | 2007 | The Journal of Immunology
Exposure of skin to UVB radiation (290-320 nm) modulates the immune system, with most studies showing a suppression of Th1-driven ..
Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery
M Kendall, TJ Mitchell, G Costigan, M Armitage, JC Lenzo, JA Thomas, C von Garnier, GR Zosky, DJ Turner, PA Stumbles, PD Sly, PG Holt, WR Thomas
Journal article | 2006 | Journal of Allergy and Clinical Immunology
BACKGROUND: Biolistic injections provide a needle-free delivery of antigen-laden microparticles to the epithelium. The precision o..
Type I IFN-beta gene therapy suppresses cardiac CD8( ) T-cell infiltration during autoimmune myocarditis
EJ Bartlett, JC Lenzo, S Sivamoorthy, JP Mansfield, VS Cull, CM James
Journal article | 2004 | Immunology and Cell Biology
Gene therapy using DNA encoding type I IFN subtypes IFNA6, IFNA9 and IFNB suppresses murine cytomegalovirus (MCMV)-myocarditis, a ..
Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-alpha therapy
JC Lenzo, JP Mansfield, S Sivamoorthy, VS Cull, CM James
Journal article | 2003 | Cellular Immunology
Cytomegalovirus-induced myocarditis is largely immune-mediated. BALB/c mice produced higher levels of IL-4 in the heart indicative..
Synergy of type I interferon-A6 and interferon-B naked DNA immunotherapy for cytomegalovirus infection
EJ Bartlett, VS Cull, NL Brekalo, JC Lenzo, CM James
Journal article | 2002 | Immunology and Cell Biology
Delivery of type I IFN transgenes by naked DNA immunization can protect against cytomegalovirus infection and myocarditis. Here, w..
Isolation and characterisation of a 13.8-kDa bacteriolytic enzyme from house dust mite extracts: homology with prokaryotic proteins suggests that the enzyme could be bacterially derived
LT Mathaba, CH Pope, J Lenzo, M Hartofillis, H Peake, RL Moritz, RJ Simpson, A Bubert, PJ Thompson, GA Stewart
Journal article | 2002 | FEMS Immunology and Medical Microbiology
Characterisation of murine cytomegalovirus myocarditis: Cellular infiltration of the heart and virus persistence
JC Lenzo, D Fairweather, V Cull, GR Shellam, CM James
Journal article | 2002 | Journal of Molecular and Cellular Cardiology
Myocarditis triggered by a viral infection has integral viral and immunological aspects associated with the pathogenesis of diseas..
Immunomodulation of murine cytomegalovirus-induced myocarditis in mice treated with lipopolysaccharide and tumor necrosis factor
JC Lenzo, D Fairweather, GR Shellam, CM Lawson
Journal article | 2001 | Cellular Immunology
Murine cytomegalovirus (MCMV) infection of BALB/c mice produces acute and chronic myocarditis similar to clinical disease in human..
Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice
JC Lenzo, GR Shellam, CM Lawson
Journal article | 2001 | Antimicrobial Agents and Chemotherapy
The cardiovascular disease myocarditis is characterized by inflammation and necrosis of cardiac muscle. This disease has been asso..
Gamma-glutamylcysteine synthetase activity in human lung epithelial (A549) cells: Factors influencing its measurement
S Ray, NLA Misso, JC Lenzo, C Robinson, PJ Thompson
Journal article | 1999 | Free Radical Biology and Medicine
Despite the central role of gamma-glutamylcysteine synthetase (gammaGCS) in lung antioxidant defenses, the limited studies of the ..
Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer
DN Watkins, JC Lenzo, A Segal, MJ Garlepp, PJ Thompson
Journal article | 1999 | European Respiratory Journal
The beneficial effects of cyclo-oxygenase (COX) inhibitors in both colon cancer and adenomatous polyps suggest a role for the pros..
Expression and localization of COX-2 in human airways and cultured airway epithelial cells
DN Watkins, DJ Peroni, JC Lenzo, DA Knight, MJ Garlepp, PJ Thompson
Journal article | 1999 | European Respiratory Journal
Cyclo-oxygenase is the rate-limiting enzyme in the prostanoid pathway. Although expression of the inducible isoform of cyclo-oxyge..
The roles of tumour necrosis factor-alpha, interleukin-1 and interleukin-12 in murine cytomegalovirus infection
ST Yerkovich, SD Olver, JC Lenzo, CD Peacock, P Price
Journal article | 1997 | Immunology
The roles of the inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and IL-12, in murine cytome..
Honours, Awards and Fellowships
Piksters Periodontal Award
Australian Dental Industry Association (ADIA) Research Award