Jason Lenzo

T helper 17 cell-related cytokines in serum and saliva during management of periodontitis.

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Ivan B Darby, Neil M O'Brien-Simpson, Eric C Reynolds

Journal article  |  2020  |  Cytokine

AIM: T helper (Th)17 cells are implicated in the pathogenesis of periodontitis. This study investigated the effect of periodontal ..

Peripheral neutrophil phenotypes during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Neil M O'Brien-Simpson, Ivan B Darby

Journal article  |  2020  |  Journal of Periodontal Research

BACKGROUND AND OBJECTIVES: Neutrophils are emerging as a key player in periodontal pathogenesis. The surface expression of cellula..

Monospecies and polymicrobial biofilms differentially regulate the phenotype of genotype-specific oral cancer cells

Mohd Hafiz Arzmi, Nicola Cirillo, Jason C Lenzo, Deanne V Catmull, Neil O'Brien-Simpson, Eric C Reynolds, Stuart Dashper, Michael McCullough

Journal article  |  2019  |  Carcinogenesis

Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity

Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao

Journal article  |  2018  |  Advanced Healthcare Materials

Designing antibiotic peptide polymer adjuvants for multidrug resistant bacteria

Neil O'Brien-Simpson, Shu Lam, Jason C Lenzo, James Holden, Greg Qiao, Eric Reynolds

Conference Proceedings  |  2018  |  JOURNAL OF PEPTIDE SCIENCE

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2

James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca KH Orth, Ashley Mansell, Eric C Reynolds

Journal article  |  2017  |  INFECTION AND IMMUNITY

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, William Singleton, Alexis Perez-Gonzalez, Ashley Mansell, Eric C Reynolds

Journal article  |  2017  |  FRONTIERS IN IMMUNOLOGY

Rapid Chair-Side Test for Detection of Porphyromonas gingivalis

NM O'Brien-Simpson, K Burgess, JC Lenzo, GC Brammar, IB Darby, EC Reynolds

Journal article  |  2017  |  JOURNAL OF DENTAL RESEARCH

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan, Gail C Brammar, Katrina A Walsh, William Singleton, Rebecca KH Orth, Nada Slakeski, Keith J Cross, Ivan B Darby, Dorit Becher, Tony Rowe, Adriana Baz Morelli, Andrew Hammet, Andrew Nash, Anna Brown, Bing Ma, Didier Vingadassalom, Jacqueline McCluskey, et al.

Journal article  |  2016  |  NPJ VACCINES

Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses

Katelyn T Gause, Yan Yan, Neil M O'Brien-Simpson, Jiwei Cui, Jason C Lenzo, Eric C Reynolds, Frank Caruso

Journal article  |  2016  |  ADVANCED FUNCTIONAL MATERIALS

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

Shu J Lam, Neil M O'Brien-Simpson, Namfon Pantarat, Adrian Sulistio, Edgar HH Wong, Yu-Yen Chen, Jason C Lenzo, James A Holden, Anton Blencowe, Eric C Reynolds, Greg G Qiao

Journal article  |  2016  |  Nature Microbiology

Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis

Jason C Lenzo, Neil M O'Brien-Simpson, Rebecca K Orth, Helen L Mitchell, Stuart G Dashper, Eric C Reynolds

Journal article  |  2016  |  INFECTION AND IMMUNITY

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis

Roselind S Lam, Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Shao B Fong, Eric C Reynolds

Journal article  |  2016  |  PLOS ONE

Determination of Active Phagocytosis of Unopsonized Porphyromonas gingivalis by Macrophages and Neutrophils Using the pH-Sensitive Fluorescent Dye pHrodo

Jason C Lenzo, Neil M O'Brien-Simpson, Jessica Cecil, James A Holden, Eric C Reynolds

Journal article  |  2016  |  INFECTION AND IMMUNITY

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds

Journal article  |  2016  |  PLOS ONE

Tannerella forsythia Outer Membrane Vesicles Are Enriched with Substrates of the Type IX Secretion System and TonB-Dependent Receptors

Paul D Veith, Yu-Yen Chen, Dina Chen, Neil M O'Brien-Simpson, Jessica D Cecil, James A Holden, Jason C Lenzo, Eric C Reynolds

Journal article  |  2015  |  JOURNAL OF PROTEOME RESEARCH

GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model

Roselind S Lam, Neil M O'Brien-Simpson, John A Hamilton, Jason C Lenzo, James A Holden, Gail C Brammar, Rebecca K Orth, Yan Tan, Katrina A Walsh, Andrew J Fleetwood, Eric C Reynolds

Journal article  |  2015  |  IMMUNOLOGY AND CELL BIOLOGY

Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States

Katelyn T Gause, Yan Yan, Jiwei Cui, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Frank Caruso

Journal article  |  2015  |  ACS NANO

Macrophage Depletion Abates Porphyromonas gingivalis-Induced Alveolar Bone Resorption in Mice

Roselind S Lam, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Gail C Brammar, Katrina A Walsh, Judith E McNaughtan, Dennis K Rowler, Nico Van Rooijen, Eric C Reynolds

Journal article  |  2014  |  Journal of Immunology

The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor

Agnieszka Swierczak, Andrew D Cook, Jason C Lenzo, Christina M Restall, Judy P Doherty, Robin L Anderson, John A Hamilton

Journal article  |  2014  |  Cancer Immunology Research

Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines

Yan Yan, Katelyn T Gause, Marloes MJ Kamphuis, Ching-Seng Ang, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Edouard C Nice, Frank Caruso

Journal article  |  2013  |  ACS NANO

Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation

Jason C Lenzo, Amanda L Turner, Andrew D Cook, Ross Vlahos, Gary P Anderson, Eric C Reynolds, John A Hamilton

Journal article  |  2012  |  Immunology and Cell Biology

Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens

Paula T Cunningham, Claire E Elliot, Jason C Lenzo, Andrew G Jarnicki, Alexander N Larcombe, Graeme R Zosky, Patrick G Holt, Wayne R Thomas

Journal article  |  2012  |  International Archives of Allergy and Immunology

BACKGROUND: Innate properties that enhance immune responses might increase the propensity of certain allergens to induce allergic ..

Regulation of Systemic and Local Myeloid Cell Subpopulations by Bone Marrow Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor in Experimental Inflammatory Arthritis

Andrew D Cook, Amanda L Turner, Emma L Braine, Jarrad Pobjoy, Jason C Lenzo, John A Hamilton

Journal article  |  2011  |  Arthritis and Rheumatism

Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement

Andrew D Cook, Christine M De Nardo, Emma L Braine, Amanda L Turner, Ross Vlahos, Kerrie J Way, S Kaye Beckman, Jason C Lenzo, John A Hamilton

Journal article  |  2010  |  Arthritis Research & Therapy

Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models

Christine M De Nardo, Jason C Lenzo, Jarrad Pobjoy, John A Hamilton, Andrew D Cook

Journal article  |  2010  |  Arthritis Research & Therapy

The role of CSF-1 and GM-CSF in the control of monocyte subpopulations

Jason C Lenzo, Amanda L Turner, John A Hamilton

Conference Proceedings  |  2007  |  Cytokine

Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigen

Jacqueline P McGlade, Shelley Gorman, Jason C Lenzo, Jamie W Tan, Takeshi Watanabe, John J Finlay-Jones, Wayne R Thomas, Prue H Hart

Journal article  |  2007  |  The Journal of Immunology

Exposure of skin to UVB radiation (290-320 nm) modulates the immune system, with most studies showing a suppression of Th1-driven ..

The role of CSF-1 and GM-CSF in the control of monocyte subpopulations.

Jason C Lenzo, Amanda L Turner, John A Hamilton

Conference Proceedings  |  2007  |  JOURNAL OF LEUKOCYTE BIOLOGY

The effect of tissue type-plasminogen activator deletion and associated fibrin (ogen) deposition on macrophage localization in peritoneal inflammation

AD Cook, R Vlahos, CM Massa, EL Braine, JC Lenzo, AL Turner, KJ Way, JA Hamilton

Journal article  |  2006  |  Thrombosis and Haemostasis

Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery

M Kendall, TJ Mitchell, G Costigan, M Armitage, JC Lenzo, JA Thomas, C von Garnier, GR Zosky, DJ Turner, PA Stumbles, PD Sly, PG Holt, WR Thomas

Journal article  |  2006  |  Journal of Allergy and Clinical Immunology

BACKGROUND: Biolistic injections provide a needle-free delivery of antigen-laden microparticles to the epithelium. The precision o..

Type I IFN-beta gene therapy suppresses cardiac CD8( ) T-cell infiltration during autoimmune myocarditis

EJ Bartlett, JC Lenzo, S Sivamoorthy, JP Mansfield, VS Cull, CM James

Journal article  |  2004  |  Immunology & Cell Biology

Gene therapy using DNA encoding type I IFN subtypes IFNA6, IFNA9 and IFNB suppresses murine cytomegalovirus (MCMV)-myocarditis, a ..

Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-alpha therapy

JC Lenzo, JP Mansfield, S Sivamoorthy, VS Cull, CM James

Journal article  |  2003  |  Cellular Immunology

Cytomegalovirus-induced myocarditis is largely immune-mediated. BALB/c mice produced higher levels of IL-4 in the heart indicative..

Synergy of type I interferon-A6 and interferon-B naked DNA immunotherapy for cytomegalovirus infection

EJ Bartlett, VS Cull, NL Brekalo, JC Lenzo, CM James

Journal article  |  2002  |  Immunology & Cell Biology

Delivery of type I IFN transgenes by naked DNA immunization can protect against cytomegalovirus infection and myocarditis. Here, w..

Isolation and characterisation of a 13.8-kDa bacteriolytic enzyme from house dust mite extracts: homology with prokaryotic proteins suggests that the enzyme could be bacterially derived

LT Mathaba, CH Pope, J Lenzo, M Hartofillis, H Peake, RL Moritz, RJ Simpson, A Bubert, PJ Thompson, GA Stewart

Journal article  |  2002  |  FEMS Immunology and Medical Microbiology

Characterisation of murine cytomegalovirus myocarditis: Cellular infiltration of the heart and virus persistence

JC Lenzo, D Fairweather, V Cull, GR Shellam, CM James

Journal article  |  2002  |  Journal of Molecular and Cellular Cardiology

Myocarditis triggered by a viral infection has integral viral and immunological aspects associated with the pathogenesis of diseas..

Cytomegalovirus-induced myocarditis - An animal model for understanding pathogenesis and therapy

JC Lenzo, CM Lawson

Journal article  |  2001  |  International Antiviral News

Immunomodulation of murine cytomegalovirus-induced myocarditis in mice treated with lipopolysaccharide and tumor necrosis factor

JC Lenzo, D Fairweather, GR Shellam, CM Lawson

Journal article  |  2001  |  Cellular Immunology

Murine cytomegalovirus (MCMV) infection of BALB/c mice produces acute and chronic myocarditis similar to clinical disease in human..

Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice

JC Lenzo, GR Shellam, CM Lawson

Journal article  |  2001  |  Antimicrobial Agents and Chemotherapy

The cardiovascular disease myocarditis is characterized by inflammation and necrosis of cardiac muscle. This disease has been asso..

Expression and localization of cyclooxygenase isoforms in non-small cell lung cancer (NSCLC)

PJ Thompson, D Neil Watkins, JC Lenzo, A Segal, MJ Garlepp

Journal article  |  1999  |  Respirology

Gamma-glutamylcysteine synthetase activity in human lung epithelial (A549) cells: Factors influencing its measurement

S Ray, NLA Misso, JC Lenzo, C Robinson, PJ Thompson

Journal article  |  1999  |  Free Radical Biology and Medicine

Despite the central role of gamma-glutamylcysteine synthetase (gammaGCS) in lung antioxidant defenses, the limited studies of the ..

Localisation of oncostatin M receptors (OSMR) in human airways by immunohistochemistry: Altered pattern of distribution in asthma

D Knight, J Lenzo, A James, P Thompson, N Carroll

Journal article  |  1999  |  Respirology

Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer

DN Watkins, JC Lenzo, A Segal, MJ Garlepp, PJ Thompson

Journal article  |  1999  |  European Respiratory Journal

The beneficial effects of cyclo-oxygenase (COX) inhibitors in both colon cancer and adenomatous polyps suggest a role for the pros..

Expression and localization of COX-2 in human airways and cultured airway epithelial cells

DN Watkins, DJ Peroni, JC Lenzo, DA Knight, MJ Garlepp, PJ Thompson

Journal article  |  1999  |  European Respiratory Journal

Cyclo-oxygenase is the rate-limiting enzyme in the prostanoid pathway. Although expression of the inducible isoform of cyclo-oxyge..

The roles of tumour necrosis factor-alpha, interleukin-1 and interleukin-12 in murine cytomegalovirus infection

ST Yerkovich, SD Olver, JC Lenzo, CD Peacock, P Price

Journal article  |  1997  |  Immunology

The roles of the inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and IL-12, in murine cytome..