Ella Thompson

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio, Natasha S Anstee, Veronique Litalien, Ella Thompson, Thomas Morley, Sarah MacRaild, Ing S Tiong, Rhiannon Morris, Karen Dun, Adrian Zordan, Jaynish Shah, Sebastien Banquet, Ensar Halilovic, Erick Morris, Marco J Herold, Guillaum Lessene, et al.

Journal article  |  2023  |  BLOOD

Randomized trials in acute myeloid leukemia (AML) have demonstrated improved survival by the BCL-2 inhibitor venetoclax combined w..

Clinically relevant variation in FLT3-ITD quantitation as a result of PCR cycle number and ITD insertion size

Ing S Tiong, Nikky Andrieska, Phuong Dang, Piers Blombery, Ella Thompson, Michelle McBean, Kate Jones

Journal article  |  2023  |  PATHOLOGY

FLT3 internal tandem duplication (ITD) quantitation is key to prognostication in acute myeloid leukaemia (AML). One potential sour..

EE141 Cost-Effectiveness of TP53 and IGHV Biomarker Testing Prior to First-Line Treatment With Novel Agents for Chronic Lymphocytic Leukemia

M Vu, K Degeling, E Thompson, P Blombery, DA Westerman, M IJzerman

Journal article  |  2022  |  Value in Health

Biallelic Deleterious Germline SH2B3 Variants Cause a Novel Clinical Syndrome of Myeloproliferation and Multi-Organ Autoimmunity

Piers Blombery, Vahid Pazhakh, Adriana Albuquerque, Jesmeen Maimaris, Lingge Tu, Brenda Briones, Florence Evans, Ella Thompson, Ben Carpenter, Julie Curtin, Jonathan Lambert, Siobhan Burns, Graham John Lieschke

Journal article  |  2022  |  Blood

Detection of Novel Occult Germline Multi-Exon Deletions in Patients with DDX41 Familial Predisposition to Myeloid Malignancy

Anna Maierhofer, Lucy C Fox, Stephan Hutter, Constance Baer, Ella Thompson, Tamia Nguyen, Nicole Den Elzen, Robin J Filshie, Ing S Tiong, Niroshan Nadarajah, Manja Meggendorfer, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach, Piers Blombery

Journal article  |  2022  |  BLOOD

1442 Investigating the tumour immune microenvironment of breast implant associated anaplastic large cell lymphoma using single cell RNA sequencing

Harini de Silva, Niko Thio, Piers Blombery, Ella Thompson, Anand Deva, Miles Prince, Paul Neeson, Criselle DSouza

Conference Proceedings  |  2022  |  Regular and Young Investigator Award Abstracts

SOHO State of the Art Updates and Next Questions | Mechanisms of Resistance to BCL2 Inhibitor Therapy in Chronic Lymphocytic Leukemia and Potential Future Therapeutic Directions.

Rory Bennett, Ella Thompson, Constantine Tam

Journal article  |  2022  |  Clin Lymphoma Myeloma Leuk

Chronic lymphocytic leukaemia (CLL) constitutively overexpresses B-cell lymphoma 2 (BCL2) with consequent dysregulation of intrins..

Enrichment of BTK Leu528Trp mutations in patients with CLL on zanubrutinib: potential for pirtobrutinib cross-resistance

Piers Blombery, Ella R Thompson, Thomas E Lew, Ing Soo Tiong, Rory Bennett, Chan Y Cheah, Katharine Louise Lewis, Sasanka M Handunnetti, Chloe Pek Sang Tang, Andrew Roberts, John F Seymour, Constantine S Tam

Journal article  |  2022  |  BLOOD ADVANCES

The covalent Bruton's tyrosine kinase inhibitors (BTKis) are highly effective for the treatment of chronic lymphocytic leukemia (C..

Methyl-CpG binding domain 4, DNA glycosylase (MBD4)-associated neoplasia syndrome associated with a homozygous missense variant in MBD4: Expansion of an emerging phenotype

Piers Blombery, Georgina L Ryland, Lucy C Fox, Zornitza Stark, Meg Wall, Anna Jarmolowicz, Ain Roesley, Ella R Thompson, Sean M Grimmond, Shyam Panicker, Fiona Kwok

Journal article  |  2022  |  BRITISH JOURNAL OF HAEMATOLOGY

Health economic evidence for the use of molecular biomarker tests in hematological malignancies: A systematic review

Martin Vu, Koen Degeling, Ella R Thompson, Piers Blombery, David Westerman, Maarten J IJzerman

Journal article  |  2022  |  EUROPEAN JOURNAL OF HAEMATOLOGY

OBJECTIVES: Molecular biomarker tests can inform the clinical management of genomic heterogeneous hematological malignancies, yet ..