Richard Saffery

Identifying the lungs as a susceptible site for allele-specific regulatory changes associated with type 1 diabetes risk.

Daniel Ho, Denis M Nyaga, William Schierding, Richard Saffery, Jo K Perry, John A Taylor, Mark H Vickers, Andreas W Kempa-Liehr, Justin M O'Sullivan

Journal article  |  2021  |  Commun Biol

Type 1 diabetes (T1D) etiology is complex. We developed a machine learning approach that ranked the tissue-specific transcription ..

Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts.

Doretta Caramaschi, James Jungius, Christian M Page, Boris Novakovic, Richard Saffery, Jane Halliday, Sharon Lewis, Maria C Magnus, Stephanie J London, Siri E Håberg, Caroline L Relton, Deborah A Lawlor, Hannah R Elliott

Journal article  |  2021  |  Hum Reprod

STUDY QUESTION: Is cord blood DNA methylation associated with having been conceived by medically assisted reproduction? SUMMARY AN..

Diet quality trajectories and cardiovascular phenotypes/metabolic syndrome risk by 11-12 years

Jessica A Kerr, Richard S Liu, Constantine E Gasser, Fiona K Mensah, David Burgner, Kate Lycett, Alanna N Gillespie, Markus Juonala, Susan A Clifford, Tim Olds, Richard Saffery, Lisa Gold, Mengjiao Liu, Peter Azzopardi, Ben Edwards, Terence Dwyer, Melissa Wake

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF OBESITY

OBJECTIVE: To investigate associations between early-life diet trajectories and preclinical cardiovascular phenotypes and metaboli..

Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

Melanie R Neeland, Samantha Bannister, Vanessa Clifford, Kate Dohle, Kim Mulholland, Philip Sutton, Nigel Curtis, Andrew C Steer, David P Burgner, Nigel W Crawford, Shidan Tosif, Richard Saffery

Journal article  |  2021  |  NATURE COMMUNICATIONS

Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults an..

Clarifying the Sweeping Consequences of COVID-19 in Pregnant Women, Newborns, and Children With Existing Cohorts

Yanhong Jessika Hu, Melissa Wake, Richard Saffery

Journal article  |  2021  |  JAMA PEDIATRICS

Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food-allergic infants

Melanie R Neeland, Amanda R Tursi, Kirsten P Perrett, Richard Saffery, Jennifer J Koplin, Kari C Nadeau, Sandra Andorf

Journal article  |  2021  |  PEDIATRIC ALLERGY AND IMMUNOLOGY

The influence of vitamin D on human health is strongly associated with tolerogenic immune function, skewing the immune response to..

Trimethylamine N-oxide (TMAO) Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults

Stephanie Andraos, Beatrix Jones, Katherine Lange, Susan A Clifford, Eric B Thorstensen, Jessica A Kerr, Melissa Wake, Richard Saffery, David P Burgner, Justin M O'Sullivan

Journal article  |  2021  |  CURRENT DEVELOPMENTS IN NUTRITION

Background: Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiom..

Gut Microbiome Composition Remains Stable in Individuals with Diabetes-Related Early to Late Stage Chronic Kidney Disease

Ashani Lecamwasam, Tiffanie M Nelson, Leni Rivera, Elif I Ekinci, Richard Saffery, Karen M Dwyer

Journal article  |  2021  |  BIOMEDICINES

(1) Background: Individuals with diabetes and chronic kidney disease display gut dysbiosis when compared to healthy controls. Howe..

DNA methylation analysis of candidate genes associated with dementia in peripheral blood

Peter D Fransquet, Paul Lacaze, Richard Saffery, James Phung, Emily Parker, Raj C Shah, Anne Murray, Robyn L Woods, Joanne Ryan

Journal article  |  2020  |  EPIGENOMICS

Aim: To investigate whether genes implicated in dementia pathogenesis are differently methylated in peripheral blood. Materials & ..

Epigenetic Patterns in Five-Year-Old Children Exposed to a Low Glycemic Index Dietary Intervention during Pregnancy: Results from the ROLO Kids Study

Aisling A Geraghty, Alex Sexton-Oates, Eileen C O'Brien, Richard Saffery, Fionnuala M McAuliffe

Journal article  |  2020  |  NUTRIENTS

A range of in utero and early-life factors can influence offspring epigenetics, particularly DNA methylation patterns. This study ..