Oneel Patel

The Protective Effect of Zinc Against Liver Ischaemia Reperfusion Injury in a Rat Model of Global Ischaemia

Ernest Cheung, Mehrdad Nikfarjam, Louise Jackett, Damien M Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2020  |  Journal of Clinical and Experimental Hepatology

Experimental rat models for contrast-induced nephropathy; A comprehensive review

M Perera, J Ischia, D Bolton, A Shulkes, GS Baldwin, O Patel

Journal article  |  2020  |  Journal of Nephropathology

Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (C..

Why is it worth testing the ability of zinc to protect against ischaemia reperfusion injury for human application

Joseph Ischia, Damien M Bolton, Oneel Patel

Journal article  |  2019  |  Metallomics

Ischaemia (interruption in the blood/oxygen supply) and subsequent damage induced by reperfusion (restoration of blood/oxygen supp..

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic

Dermot O'Kane, Graham S Baldwin, Damien M Bolton, Joseph J Ischia, Oneel Patel

Journal article  |  2019  |  Journal of Nephrology

Metformin may offer no protective effect in men undergoing external beam radiation therapy for prostate cancer

Weranja KB Ranasinghe, Scott Williams, Joseph Ischia, David Wetherell, Graham Baldwin, Arthur Shulkes, Shomik Sengupta, Damien Bolton, Oneel Patel

Conference Proceedings  |  2019  |  BJU International

Zinc protects the kidney against ischaemia-reperfusion injury: investigating the mechanisms of protection in wild-type and genetic-knockout murine strains

D O'Kane, J Du Plessis, A Shulkes, G Baldwin, D Bolton, J Ischia, O Patel

Conference Proceedings  |  2019  |  BJU INTERNATIONAL

Corrigendum to "Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?"

Kapil Sethi, Kenny Rao, Arthur Shulkes, Graham Baldwin, Damien Bolton, Oneel Patel, Joseph Ischia

Journal article  |  2019  |  International Journal of Cell Biology

[This corrects the article DOI: 10.1155/2018/9852791.].

Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model

Dermot O'Kane, Luke Gibson, Clive N May, Justin du Plessis, Arthur Shulkes, Graham S Baldwin, Damien Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2018  |  BioMetals

Zinc ion dyshomeostasis increases resistance of prostate cancer cells to oxidative stress via upregulation of HIF1α.

David Wetherell, Graham S Baldwin, Arthur Shulkes, Damien Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2018  |  Oncotarget

Zinc ions (Zn2+) are known to influence cell survival and proliferation. However the homeostatic regulation of Zn2+ and their role..

Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?

Kapil Sethi, Kenny Rao, Damien Bolton, Oneel Patel, Joseph Ischia

Journal article  |  2018  |  International Journal of Cell Biology

Partial nephrectomy (open or minimally invasive) usually requires temporary renal arterial occlusion to limit intraoperative bleed..

Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent

Kenny Rao, Kapil Sethi, Joseph Ischia, Luke Gibson, Laurence Galea, Lin Xiao, Mildred Yim, Mike Chang, Nathan Papa, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2017  |  PLOS ONE

Progastrin: a potential predictive marker of liver metastasis in colorectal cancer

David A Westwood, Oneel Patel, Christopher Christophi, Arthur Shulkes, Graham S Baldwin

Journal article  |  2017  |  International Journal of Colorectal Disease

Zinc Ions Mediate Gastrin Expression, Proliferation, and Migration Downstream of the Cholecystokinin-2 Receptor

Mike Chang, Lin Xiao, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2016  |  Endocrinology

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

Dannel Yeo, Hong He, Oneel Patel, Andrew M Lowy, Graham S Baldwin, Mehrdad Nikfarjam

Journal article  |  2016  |  BMC CANCER

Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy

Joseph Ischia, Oneel Patel, Kapil Sethi, Marianne S Nordlund, Damien Bolton, Arthur Shulkes, Graham S Baldwin

Journal article  |  2015  |  BJU International

HIF1 alpha Expression under Normoxia in Prostate Cancer-Which Pathways to Target?

Weranja KB Ranasinghe, Graham S Baldwin, Damien Bolton, Arthur Shulkes, Joseph Ischia, Oneel Patel

Journal article  |  2015  |  Journal of Urology

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo

Kathryn M Marshall, Marie Laval, Ortis Estacio, Damien F Hudson, Paul Kalitsis, Arthur Shulkes, Graham S Baldwina, Oneel Patel

Journal article  |  2015  |  Metallomics

Gastrin mediates resistance to hypoxia-induced cell death in xenografts of the human colorectal cancer cell line LoVo

David A Westwood, Oneel Patel, Graham S Baldwin

Journal article  |  2014  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Normoxic regulation of HIF-1α in prostate cancer.

Weranja KB Ranasinghe, Graham S Baldwin, Arthur Shulkes, Damien Bolton, Oneel Patel

Journal article  |  2014  |  Nature Reviews Urology

The effects of nonspecific HIF1 alpha inhibitors on development of castrate resistance and metastases in prostate cancer

Weranja KB Ranasinghe, Shomik Sengupta, Scott Williams, Mike Chang, Arthur Shulkes, Damien M Bolton, Graham Baldwin, Oneel Patel

Journal article  |  2014  |  CANCER MEDICINE

Zinc preconditioning protects the rat kidney against ischemic injury

K Rao, M Yim, L Galea, D Bolton, A Shulkes, G Baldwin, O Patel

Conference Proceedings  |  2014  |  BJU INTERNATIONAL

Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues

Joseph Ischia, Oneel Patel, Damien Bolton, Arthur Shulkes, Graham S Baldwin

Journal article  |  2014  |  BJU International

Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter

Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2014  |  JOURNAL OF MOLECULAR ENDOCRINOLOGY

ZINC PRECONDITIONING PROTECTS THE RAT KIDNEY AGAINST ISCHEMIC INJURY

K Rao, M Yim, L Galea, D Bolton, A Shulkes, G Baldwin, O Patel

Journal article  |  2014  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1 alpha

Kevin H Liu, Huynh Nhi, Oneel Patel, Arthur Shulkes, Graham Baldwin, Hong He

Journal article  |  2013  |  CANCER LETTERS

The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo

Kathryn M Marshall, Oneel Patel, Gianni Bramante, Marie Laval, Mildred Yim, Graham S Baldwin, Arthur Shulkes

Journal article  |  2013  |  PEPTIDES

THE EFFECTS OF NON-SPECIFIC HIF1A INHIBITORS ON DEVELOPMENT OF CASTRATE RESISTANCE AND METASTASES IN PROSTATE CANCER

W Ranasinghe, S Sengupta, S Williams, M Chang, A Shulkes, DM Bolton, G Baldwin, O Patel

Conference Proceedings  |  2013  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

HIF-1ALPHA-DEPENDENT GASTRIN GENE EXPRESSION MEDIATES RESISTANCE TO HYPOXIA-INDUCIBLE APOPTOSIS IN A HUMAN COLORECTAL CANCER CELL LINE

DA Westwood, O Patel, A Shulkes, C Christophi, GS Baldwin

Conference Proceedings  |  2013  |  Gut

Non-specific HIF1 alpha inhibitors in men receiving androgen deprivation therapy for prostate cancer

W Ranasinghe, S Sengupta, S Williams, M Chang, A Shulkes, D Bolton, G Baldwin, O Patel

Conference Proceedings  |  2013  |  BJU International

The Role of Hypoxia-Inducible Factor 1 alpha in Determining the Properties of Castrate-Resistant Prostate Cancers

Weranja KB Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Carine Michiels, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2013  |  PLOS ONE

A RETROSPECTIVE ANALYSIS OF 100 MEN WITH PROSTATE CANCER: DOES HIF1 DETERMINE CASTRATE RESISTANCE AND ITS CHARACTERISTICS?

W Ranasinghe, L Xiao, S Kovac, M Chang, A Shulkes, D Bolton, G Baldwin, O Patel

Journal article  |  2012  |  Asia Pacific Journal of Clinical Oncology

Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)

Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2012  |  Endocrinology

Hypoxia-inducible factor 1 alpha: A screening tool for predicting development of castrate resistant prostate cancer

Weranja Kalana Bodhisiri Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Damien M Bolton, Graham Baldwin, Oneel Patel

Conference Proceedings  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

Hypoxia-inducible factor 1 alpha: A screening tool for predicting development of castrate resistant prostate cancer.

Weranja Kalana Bodhisiri Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Damien M Bolton, Graham Baldwin, Oneel Patel

Conference Proceedings  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

The role of hypoxia inducible factor 1 alpha as a potential biomarker for the development and prognosis of castrate resistant prostate cancers

WKB Ranasinghe, L Xiao, S Kovac, M Chang, A Shulkes, D Bolton, G Baldwin, O Patel

Conference Proceedings  |  2012  |  BJU INTERNATIONAL

Comparison of renal preconditioning techniques in a rat model

K Sethi, O Patel, J Ischia, L Xiao, G Baldwin, A Shulkes, DM Bolton

Conference Proceedings  |  2012  |  BJU INTERNATIONAL

Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo

Oneel Patel, Daniel Clyde, Mike Chang, Marianne S Nordlund, Rohan Steel, Bruce E Kemp, D Mark Pritchard, Arthur Shulkes, Graham S Baldwin

Journal article  |  2012  |  Endocrinology

Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo

O Patel, undefined Clyde, AA Shulkes, G Baldwin, undefined Chang, undefined Nordlund, undefined Steel, undefined Kemp, undefined Pritchard

Journal article  |  2012  |  Endocrinology

COBALT PRECONDITIONING REDUCES RENAL INJURY PRIOR TO TEMPORARY ISCHEMIA IN THE RAT MODEL

Kapil Sethi, Oneel Patel, Lin Xiao, Joseph Ischia, Graham Baldwin, Arthur Schulkes, Damien Bolton

Journal article  |  2011  |  JOURNAL OF ENDOUROLOGY

Comparison of ischaemic preconditioning techniques of the kidney in a rat model

K Sethi, O Patel, J Ischia, L Xiao, M Chang, G Baldwin, A Shulkes, DM Bolton

Journal article  |  2011  |  BJU INTERNATIONAL

Ferric ions inhibit proteolytic processing of progastrin

Gianni Bramante, Oneel Patel, Arthur Shulkes, Graham S Baldwin

Journal article  |  2011  |  Biochemical and Biophysical Research Communications

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway

Oneel Patel, Kathryn M Marshall, Gianni Bramante, Graham S Baldwin, Arthur Shulkes

Journal article  |  2010  |  Regulatory Peptides

Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor

Suzana Kovac, Lin Xiao, Arthur Shulkes, Oneel Patel, Graham S Baldwin

Journal article  |  2010  |  FEBS Letters

Biological activities of progastrin peptides

KM Marshall, M Yim, O Patel, G Bramante, A Ferrand, GS Baldwin, A Shulkes

Conference Proceedings  |  2010  |  Regulatory Peptides

Evolution of gastrointestinal hormones: the cholecystokinin/gastrin family

Graham S Baldwin, Oneel Patel, Arthur Shulkes

Journal article  |  2010  |  Current Opinion in Endocrinology, Diabetes and Obesity

GRP expression in prostate cancer

CL Yip, R Lockie, J Ischia, O Patel, D Bolton, G Baldwin, A Shulkes

Conference Proceedings  |  2010  |  BJU INTERNATIONAL

In-vitro activation of hypoxia inducible factor by gastrin releasing peptide in renal cell cancer

K Sethi, O Patel, J Ischia, D Bolton, G Baldwin, A Shulkes

Conference Proceedings  |  2010  |  BJU INTERNATIONAL

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway

O Patel, K Marshall, G BRAMANTE, G Baldwin, AA Shulkes

Journal article  |  2010  |  Regulatory Peptides

The action of gastrin-releasing peptide and its precursor (proGRP) on xenografts of the renal cancer cell line ACHN

J Ischia, O Patel, R Lockie, D Bolton, G Baldwin, A Shulkes

Conference Proceedings  |  2009  |  BJU INTERNATIONAL

Prostate Cancer cell lines express GRP and Pro-GRP receptors

CL Yip, L Ischia, J Ischia, O Patel, D Bolton, G Baldwin, A Shulkes

Conference Proceedings  |  2009  |  BJU INTERNATIONAL

Gastrin-releasing peptide: Different forms, different functions

Joseph Ischia, Oneel Patel, Arthur Shulkes, Graham S Baldwin

Journal article  |  2009  |  BioFactors: vitamins - autoregulatory substances - trace elements - growth factors

The role of gastrin-releasing peptide and its precursor (proGRP) in renal cell cancer

J Ischia, D Bolton, L Ischia, R Lockie, O Patel, GS Baldwin, A Shulkes

Conference Proceedings  |  2008  |  BJU INTERNATIONAL

Gastrin-releasing peptide

O PATEL, A SHULKES, G BALDWIN

Book Chapter  |  2008

Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: Biological implications

Graham S Baldwin, Oneel Patel, Arthur Shulkes

Journal article  |  2007  |  Regulatory Peptides

Recombinant C-terminal fragments of the gastrin-releasing peptide precursor are bioactive

Oneel Patel, Chelsea Dumesny, Arthur Shulkes, Graham S Baldwin

Journal article  |  2007  |  Cancer Letters

C-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor

Oneel Patel, Chelsea Dumesny, Arthur Shulkes, Graham S Baldwin

Journal article  |  2007  |  Endocrinology

Production, secretion, and biological activity of the C-terminal flanking peptide of human progastrin

Kelly A Smith, Oneel Patel, Shamilah Lachal, Ian Jennings, Bruce Kemp, John Burgess, Graham S Baldwin, Arthur Shulkes

Journal article  |  2006  |  Gastroenterology

Secretion, production and biological activity of the human C-terminal flanking peptide of progastrin

Kelly Smith, Oneel Patel, Ian Jennings, Bruce Kemp, John Burgess, Shamilah Lachal, Graham S Baldwin, Arthur Shulkes

Conference Proceedings  |  2006  |  REGULATORY PEPTIDES

C-terminal regions of the gastrin releasing peptide precursor stimulate cell proliferation via a novel receptor

Oneel Patel, Chelsea Dumesny, Arthur Shulkes, Graham S Baldwin

Conference Proceedings  |  2006  |  REGULATORY PEPTIDES

Gastrin-releasing peptide and cancer

Oneel Patel, Arthur Shulkes, Graham S Baldwin

Journal article  |  2006  |  Biochimica et Biophysica Acta - Reviews on Cancer

Gastrin-releasing peptide and cancer

Oneel Patel, Arthur Shulkes, Graham S Baldwin

Journal article  |  2006  |  BBA - Reviews on Cancer

Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP)

C Dumesny, O Patel, S Lachal, AS Giraud, GS Baldwin, A Shulkes

Journal article  |  2006  |  Endocrinology