Oneel Patel

Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities

Vidyasagar Chinni, John El-Khoury, Marlon Perera, Rinaldo Bellomo, Daryl Jones, Damien Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2021  |  BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the ..

A pilot double-blind safety and feasibility randomized controlled trial of high-dose intravenous zinc in hospitalized COVID-19 patients

Oneel Patel, Vidyasagar Chinni, John El-Khoury, Marlon Perera, Ary S Neto, Christine McDonald, Emily See, Daryl Jones, Damien Bolton, Rinaldo Bellomo, Jason Trubiano, Joseph Ischia

Journal article  |  2021  |  JOURNAL OF MEDICAL VIROLOGY

Zinc inhibits replication of the SARS-CoV virus. We aimed to evaluate the safety, feasibility, and biological effect of administer..

Zinc Preconditioning Provides Cytoprotection following Iodinated Contrast Media Exposure in In Vitro Models

Marlon Perera, Joseph Ischia, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2021  |  CONTRAST MEDIA & MOLECULAR IMAGING

Methods: Normal human proximal renal kidney cells (HK-2) were preconditioned with either increasing doses of ZnCl2 or control. Fol..

The Protective Effect of Zinc Against Liver Ischaemia Reperfusion Injury in a Rat Model of Global Ischaemia

Ernest Cheung, Mehrdad Nikfarjam, Louise Jackett, Damien M Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2020  |  JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY

Background: Ischaemia-reperfusion injury (IRI) is a major obstacle during liver transplantation and resection surgeries for cancer..

Experimental rat models for contrast-induced nephropathy; A comprehensive review

M Perera, J Ischia, D Bolton, A Shulkes, GS Baldwin, O Patel

Journal article  |  2020  |  Journal of Nephropathology

Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (C..

Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol

Marlon Perera, John El Khoury, Vidyasagar Chinni, Damien Bolton, Liang Qu, Paul Johnson, Jason Trubiano, Christine F McDonald, Daryl Jones, Rinaldo Bellomo, Oneel Patel, Joseph Ischia

Journal article  |  2020  |  BMJ OPEN

INTRODUCTION: SARS-CoV-2 (COVID-19) has caused an international pandemic of respiratory illness, resulting in significant healthca..

Why is it worth testing the ability of zinc to protect against ischaemia reperfusion injury for human application

Joseph Ischia, Damien M Bolton, Oneel Patel

Journal article  |  2019  |  METALLOMICS

Ischaemia (interruption in the blood/oxygen supply) and subsequent damage induced by reperfusion (restoration of blood/oxygen supp..

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic

Dermot O'Kane, Graham S Baldwin, Damien M Bolton, Joseph J Ischia, Oneel Patel

Journal article  |  2019  |  JOURNAL OF NEPHROLOGY

Acute kidney injury (AKI) as a result of ischaemia-reperfusion represents a major healthcare burden worldwide. Mortality rates fro..

Metformin may offer no protective effect in men undergoing external beam radiation therapy for prostate cancer

Weranja KB Ranasinghe, Scott Williams, Joseph Ischia, David Wetherell, Graham Baldwin, Arthur Shulkes, Shomik Sengupta, Damien Bolton, Oneel Patel

Conference Proceedings  |  2019  |  BJU INTERNATIONAL

OBJECTIVES: To assess whether metformin reduces radio-resistance and increases survival in men undergoing external beam radiation ..

Zinc protects the kidney against ischaemia-reperfusion injury: investigating the mechanisms of protection in wild-type and genetic-knockout murine strains

D O'Kane, J Du Plessis, A Shulkes, G Baldwin, D Bolton, J Ischia, O Patel

Conference Proceedings  |  2019  |  BJU INTERNATIONAL