Katrina Binger

Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.

Sabrina Geisberger, Hendrik Bartolomaeus, Patrick Neubert, Ralf Willebrand, Christin Zasada, Thomas Bartolomaeus, Victoria McParland, Dries Swinnen, Anneleen Geuzens, András Maifeld, Luka Krampert, Marion Vogl, Anja Mähler, Nicola Wilck, Lajos Markó, Ekin Tilic, Sofia K Forslund, Katrina J Binger, Johannes Stegbauer, Ralf Dechend, et al.

Journal article  |  2021  |  Circulation

BACKGROUND: Dietary high salt (HS) is a leading risk factor for mortality and morbidity. Serum sodium transiently increases postpr..

Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry

Joachim Kloehn, Berin A Boughton, Eleanor C Saunders, Sean O'Callaghan, Katrina J Binger, Malcolm J McConville

Journal article  |  2021  |  MBIO

Leishmania are sandfly-transmitted protists that induce granulomatous lesions in their mammalian host. Although infected host cell..

NCX1 represents an ionic Na sensing mechanism in macrophages.

Patrick Neubert, Arne Homann, David Wendelborn, Anna-Lorena Bär, Luka Krampert, Maximilian Trum, Agnes Schröder, Stefan Ebner, Andrea Weichselbaum, Valentin Schatz, Peter Linz, Roland Veelken, Jonas Schulte-Schrepping, Anna C Aschenbrenner, Thomas Quast, Christian Kurts, Sabrina Geisberger, Karl Kunzelmann, Karin Hammer, Katrina J Binger, et al.

Journal article  |  2020  |  PLoS Biol

Inflammation and infection can trigger local tissue Na+ accumulation. This Na+-rich environment boosts proinflammatory activation ..

Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression.

Maria C Demaria, Louisa Yeung, Rens Peeters, Janet L Wee, Masa Mihaljcic, Eleanor L Jones, Zeyad Nasa, Frank Alderuccio, Pamela Hall, Brodie C Smith, Katrina J Binger, Gunther Hammerling, Hang Fai Kwok, Andrew Newman, Ann Ager, Annemiek van Spriel, Michael J Hickey, Mark D Wright

Journal article  |  2020  |  iScience

Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown..

Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8( )T cells

Annabell Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Dedreia Tull, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, Axel Kallies, Malcolm McConville, Stephen J Turner, Thomas Gebhardt, Sammy Bedoui

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

The amalgamation of cellular metabolism and immunology for host immunity

Justine D Mintern, Katrina J Binger

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  JOURNAL OF CLINICAL INVESTIGATION

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle inter..

Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells

Katrina J Binger, Martin Neukam, Sudhir Gopal Tattikota, Fatimunnisa Qadri, Dmytro Puchkov, Diana M Willmes, Sabrina Wurmsee, Sabrina Geisberger, Ralf Dechend, Klemens Raile, Thomas Kurth, Genevieve Nguyen, Matthew N Poy, Michele Solimena, Dominik N Muller, Andreas L Birkenfeld

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels. Crinop..

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article  |  2019  |  IMMUNITY

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

HIF1A and NFAT5 coordinate Na -boosted antibacterial defense via enhanced autophagy and autolysosomal targeting

Patrick Neubert, Andrea Weichselbaum, Carmen Reitinger, Valentin Schatz, Agnes Schroeder, John R Ferdinand, Michaela Simon, Anna-Lorena Baer, Christoph Brochhausen, Roman G Gerlach, Stefan Tomiuk, Karin Hammer, Stefan Wagner, Ger van Zandbergen, Katrina J Binger, Dominik N Mueller, Kento Kitada, Menna R Clatworthy, Christian Kurts, Jens Titze, et al.

Journal article  |  2019  |  AUTOPHAGY

Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted ..