Leonie Quinn

MYC in Brain Development and Cancer.

Olga Zaytseva, Nan-Hee Kim, Leonie M Quinn

Journal article  |  2020  |  Int J Mol Sci

The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance o..

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study

Emma Jones, Holger Hummerich, Emmanuelle Vir, James Uphill, Athanasios Dimitriadis, Helen Speedy, Tracy Campbell, Penny Norsworthy, Liam Quinn, Jerome Whitfield, Jacqueline Linehan, Zane Jaunmuktane, Sebastian Brandner, Parmjit Jat, Akin Nihat, Tze How Mok, Parvin Ahmed, Steven Collins, Christiane Stehmann, Shannon Sarros, et al.

Journal article  |  2020  |  LANCET NEUROLOGY

Background Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders, the most common being sporadic Cre..

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.

Belal Shohayeb, Naomi Mitchell, S Sean Millard, Leonie M Quinn, Dominic CH Ng

Journal article  |  2020  |  Biochim Biophys Acta Mol Cell Res

WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although e..

Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila

Olga Zaytseva, Naomi C Mitchell, Linna Guo, Owen J Marshall, Linda M Parsons, Ross D Hannan, David L Levens, Leonie M Quinn

Journal article  |  2020  |  DEVELOPMENT

Here, we report novel tumour suppressor activity for the Drosophila Argonaute family RNA-binding protein AGO1, a component of the ..

The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development

Belal Shohayeb, Nicholas Rui Lim, Uda Ho, Zhiheng Xu, Mirella Dottori, Leonie Quinn, Dominic Chi Hiung Ng

Journal article  |  2018  |  MOLECULAR NEUROBIOLOGY

Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary ..

DNA Conformation Regulates Gene Expression: The MYC Promoter and Beyond

Olga Zaytseva, Leonie M Quinn

Journal article  |  2018  |  BIOESSAYS

Emerging evidence suggests that DNA topology plays an instructive role in cell fate control through regulation of gene expression...

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

Linda M Parsons, Nicola A Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M Quinn, Helena E Richardson

Journal article  |  2017  |  G3-GENES GENOMES GENETICS

In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper ..

Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

Nicholas R Lim, Belal Shohayeb, Olga Zaytseva, Naomi Mitchell, S Sean Millard, Dominic CH Ng, Leonie M Quinn

Journal article  |  2017  |  STEM CELL REPORTS

The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative ..

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Sandy S Hung, Analia Lesmana, Abigail Peck, Rachel Lee, Elly Tchoubrieva, Katherine M Hannan, Jane Lin, Karen E Sheppard, Katarzyna Jastrzebski, Leonie M Quinn, Lawrence I Rothblum, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2017  |  GENE

Transcription of the ribosomal RNA genes (rDNA) by RNA polymerase I (Pol I) is a major control step for ribosome synthesis and is ..

Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling

Olga Zaytseva, Leonie M Quinn

Journal article  |  2017  |  GENES

The transcription factor and cell growth regulator MYC is potently oncogenic and estimated to contribute to most cancers. Decades ..