Liyen Loh

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8 T cells.

Sneha Sant, Sergio M Quiñones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2020  |  PLOS Pathogens

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell ..

Publisher Correction: Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality.

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  Nature Communications

Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked prolifera..

Monocyte apoptotic bodies are vehicles for influenza A virus propagation

Georgia K Atkin-Smith, Mubing Duan, Damien J Zanker, Liyen Loh, Thi HO Nguyen, Marios Koutsakos, Tien Nguyen, Xiangrui Jiang, Julio Carrera, Thanh Kha Phan, Chuanxin Liu, Stephanie Paone, Sara Oveissi, Amy L Hodge, Amy A Baxter, Katherine Kedzierska, Jason M Mackenzie, Mark D Hulett, Pamuk Bilsel, Weisan Chen, et al.

Journal article  |  2020  |  Communications Biology

The disassembly of apoptotic cells into small membrane-bound vesicles termed apoptotic bodies (ApoBDs) is a hallmark of apoptosis;..

Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

Journal article  |  2020  |  Allergy

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas..

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey, et al.

Journal article  |  2020  |  The Journal of Immunology

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

Influenza A Virus-Infected Lung Epithelial Cell Co-Culture with Human Peripheral Blood Mononuclear Cells.

Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Timothy SC Hinks

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

Sensing of influenza A virus (IAV) infection by pattern recognition receptors can occur by either direct infection of lung epithel..

Study of MAIT Cell Activation in Viral Infections In Vivo.

Timothy SC Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR)..

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Michael NT Souter, Liyen Loh, Shihan Li, Bronwyn S Meehan, Nicholas A Gherardin, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, Katherine Kedzierska, Daniel G Pellicci, Zhenjun Chen, Lars Kjer-Nielsen, Alexandra J Corbett, James McCluskey, Sidonia BG Eckle

Journal article  |  2019  |  Current Protocols in Immunology

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility comp..

Multiplex Droplet Digital PCR Assay for Quantification of Human T-Cell Leukemia Virus Type 1 Subtype c DNA Proviral Load and T Cells from Blood and Respiratory Exudates Sampled in a Remote Setting

David Yurick, Georges Khoury, Bridle Clemens, Liyen Loh, Hai Pham, Katherine Kedzierska, Lloyd Einsiedel, Damian Purcell

Journal article  |  2019  |  Journal of Clinical Microbiology

Human gamma delta T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska

Journal article  |  2019  |  Clinical & Translational Immunology

Broad CD8( ) T cell cross-recognition of distinct influenza A strains in humans

Emma J Grant, Tracy M Josephs, Liyen Loh, E Bridie Clemens, Sneha Sant, Mandvi Bharadwaj, Weisan Chen, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2018  |  NATURE COMMUNICATIONS

The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8 MAIT cell pool.

Joana Dias, Caroline Boulouis, Jean-Baptiste Gorin, Robin HGA van den Biggelaar, Kerri G Lal, Anna Gibbs, Liyen Loh, Muhammad Yaaseen Gulam, Wan Rong Sia, Sudipto Bari, William YK Hwang, Douglas F Nixon, Son Nguyen, Michael R Betts, Marcus Buggert, Michael A Eller, Kristina Broliden, Annelie Tjernlund, Johan K Sandberg, Edwin Leeansyah

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites ..

MAIT CELLS CONTRIBUTE TO A PROTECTIVE ANTIVIRAL INNATE RESPONSE TO INFLUENZA INFECTION

TSC Hinks, B van Wilgenburg, L Loh, TJ Pediongco, H Wang, M Shi, Z Zhao, M Koutsakos, S Nussing, S Sant, Z Wang, C D'Souza, CF Almeida, P Reading, AJ Corbett, J McCluskey, P Klenerman, K Kedzierska

Conference Proceedings  |  2018  |  The influence of influenza: from cells to humans

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Xiaoxiao Jia, Catarina F Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn S Meehan, Axel Kallies, Dale I Godfrey, Patrick C Reading, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

MAIT cells contribute to a protective antiviral innate response to influenza infection

Timothy Hinks, Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Patrick Reading, Alexandra Corbett, James Mccluskey, Paul Klenerman, Katherine Kedzierska

Conference Proceedings  |  2018  |  Respiratory infections

Single-Cell Approach to Influenza Specific CD8( ) T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

Sneha Sant, Ludiyine Grzelak, Zhongfang Wang, Angela Pizzollal, Manbs Koutsakos, Jane Crowe, Thomas Loudoyaris, Stuart I Mannering, Glen P Westall, Linda M Wakiml, Jamie Rossjohn, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G Thomas, Liyen Loh, Thi H Nguyen, Katherine Kedzierska

Journal article  |  2018  |  Frontiers in Immunology

Age-Related Decline in Primary CD8( ) T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8( ) T Cells

Kylie M Quinn, Annette Fox, Kim L Harland, Brendan E Russ, Jasmine Li, Thi HO Nguyen, Liyen Loh, Moshe Olshanksy, Haroon Naeem, Kirill Tsyganov, Florian Wiede, Rosela Webster, Chantelle Blyth, Xavier YX Sng, Tony Tiganis, David Powell, Peter C Doherty, Stephen J Turner, Katherine Kedzierska, Nicole L La Gruta

Journal article  |  2018  |  Cell Reports

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn Meehan, Dale Godfrey, Patrick Reading, Alexandra Corbett, James McCluskey, et al.

Journal article  |  2018  |  Nature Communications

Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lung..

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey

Journal article  |  2018  |  SCIENTIFIC REPORTS

Clonally diverse CD38( )HLA-DR( )CD8( ) T cells persist during fatal H7N9 disease

Zhongfang Wang, Lingyan Zhu, Thi HO Nguyen, Yanmin Wan, Sneha Sant, Sergio M Quinones-Parra, Jeremy Chase Crawford, Auda A Eltahla, Simone Rizzetto, Rowena A Bull, Chenli Qiu, Marios Koutsakos, E Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nussing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi HO Nguyen, et al.

Journal article  |  2018  |  SCIENCE TRANSLATIONAL MEDICINE

Perturbed CD8( ) T cell immunity across universal influenza epitopes in the elderly

Thi HO Nguyen, Sneha Sant, Nicola L Bird, Emma J Grant, E Bridie Clemens, Marios Koutsakos, Sophie A Valkenburg, Stephanie Gras, Martha Lappas, Anthony Jaworowski, Jane Crowe, Liyen Loh, Katherine Kedzierska

Journal article  |  2018  |  JOURNAL OF LEUKOCYTE BIOLOGY

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Hui-Fern Koay, Nicholas A Gherardin, Anselm Enders, Liyen Loh, Laura K Mackay, Catarina F Almeida, Brendan E Russ, Claudia A Nold-Petry, Marcel F Nold, Sammy Bedoui, Zhenjun Chen, Alexandra J Corbett, Sidonia BG Eckle, Bronwyn Meehan, Yves d'Udekem, Igor E Konstantinov, Martha Lappas, Ligong Liu, Chris C Goodnow, David P Fairlie, et al.

Journal article  |  2016  |  NATURE IMMUNOLOGY

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

Liyen Loh, Zhongfang Wang, Sneha Sant, Marios Koutsakos, Sinthujan Jegaskanda, Alexandra J Corbett, Ligong Liu, David P Fairlie, Jane Crowe, Jamie Rossjohn, Jianqing Xu, Peter C Doherty, James McCluskey, Katherine Kedzierska

Journal article  |  2016  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avian influenza viruses, inflammation, and CD8( ) T Cell immunity

Zhongfang Wang, Liyen Loh, Lukasz Kedzierski, Katherine Kedzierska

Journal article  |  2016  |  Frontiers in Immunology

Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity in Intravenous Immunoglobulin as a Potential Therapeutic Against Emerging Influenza Viruses

Sinthujan Jegaskanda, Kirsten Vandenberg, Karen L Laurie, Liyen Loh, Marit Kramski, Wendy R Winnall, Katherine Kedzierska, Steven Rockman, Stephen J Kent

Journal article  |  2014  |  Journal of Infectious Diseases

Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation

Matthew S Parsons, Liyen Loh, Shayarana Gooneratne, Rob J Center, Stephen J Kent

Journal article  |  2014  |  AIDS

Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine.

L Loh, MA Ivarsson, J Michaëlsson, JK Sandberg, DF Nixon

Journal article  |  2014  |  Mucosal Immunology

Invariant natural killer T (iNKT) cells are CD1d-restricted immunoregulatory lymphocytes that share characteristics of both the in..

Universal immunity to influenza must outwit rnmune evasion

Sergio Quinones-Parra, Liyen Loh, Lorena E Brown, Katherine Kedzierska, Sophie A Valkenburg

Journal article  |  2014  |  Frontiers in Microbiology

Measuring Turnover of SIV DNA in Resting CD4 T Cells Using Pyrosequencing: Implications for the Timing of HIV Eradication Therapies

Jeanette C Reece, Alexey Martyushev, Janka Petravic, Andrew Grimm, Shayarana Gooneratne, Thakshila Amaresena, Robert De Rose, Liyen Loh, Miles P Davenport, Stephen J Kent

Journal article  |  2014  |  PLoS One

Preexisting CD8 T-cell immunity to the H7N9 influenza a virus varies across ethnicities

S Quiñones-Parra, E Grant, L Loh, THO Nguyen, KA Campbell, SYC Tong, A Miller, PC Doherty, D Vijaykrishna, J Rossjohn, S Gras, K Kedzierska

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Preexisting CD8( ) T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Sergio Quinones-Parra, Emma Grant, Liyen Loh, Thi HO Nguyen, Kristy-Anne Campbell, Steven YC Tong, Adrian Miller, Peter C Doherty, Dhanasekaran Vijaykrishna, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.

Edwin Leeansyah, Liyen Loh, Douglas F Nixon, Johan K Sandberg

Journal article  |  2014  |  Nature Communications

Innate-like, evolutionarily conserved MR1-restricted mucosa-associated invariant T (MAIT) cells represent a large antimicrobial T-..

Differential education of human fetal natural killer cells provides a mechanism for fetal-maternal tolerance.

Martin Ivarsson, Liyen Loh, Nicole Marquardt, Niklas Bjorkstrom, Magnus Westgren, Douglas Nixon, Jakob Michaelsson

Conference Proceedings  |  2013  |  Journal of Immunology

An "Escape Clock'' for Estimating the Turnover of SIV DNA in Resting CD4 T Cells

Jeanette Reece, Janka Petravic, Mehala Balamurali, Liyen Loh, Shayarana Gooneratne, Rob De Rose, Stephen J Kent, Miles P Davenport

Journal article  |  2012  |  PLoS Pathogens

Does Cytolysis by CD8( ) T Cells Drive Immune Escape in HIV Infection?

Mehala Balamurali, Janka Petravic, Liyen Loh, Sheilajen Alcantara, Stephen J Kent, Miles P Davenport

Journal article  |  2010  |  Journal of Immunology

Timing of Immune Escape Linked to Success or Failure of Vaccination

Jeanette C Reece, Liyen Loh, Sheilajen Alcantara, Caroline S Fernandez, John Stambas, Amy Sexton, Robert De Rose, Janka Petravic, Miles P Davenport, Stephen J Kent

Journal article  |  2010  |  PLoS One

Evaluation of Recombinant Influenza Virus-Simian Immunodeficiency Virus Vaccines in Macaques

Amy Sexton, Robert De Rose, Jeanette C Reece, Sheilajen Alcantara, Liyen Loh, Jessica M Moffat, Karen Laurie, Aeron Hurt, Peter C Doherty, Stephen J Turner, Stephen J Kent, John Stambas

Journal article  |  2009  |  Journal of Virology

Rates of HIV immune escape and reversion: implications for vaccination

Miles P Davenport, Liyen Loh, Janka Petravic, Stephen J Kent

Journal article  |  2008  |  Trends in Immunology (formerly Immunology Today)