Liyen Loh

Dual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation

Sara Suliman, Lars Kjer-Nielsen, Sarah K Iwany, Kattya Lopez Tamara, Liyen Loh, Ludivine Grzelak, Katherine Kedzierska, Tonatiuh A Ocampo, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Segundo R Leon, Roger Calderon, Leonid Lecca-Garcia, Megan B Murray, D Branch Moody, Ildiko Van Rhijn

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT..

Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data.

S Harsha Krovi, Liyen Loh, Andrea Spengler, Tonya Brunetti, Laurent Gapin

Journal article  |  2022  |  Semin Immunol

Innate T (Tinn) cells are a collection of T cells with important regulatory functions that have a crucial role in immunity towards..

HLA-A*11:01-restricted CD8( ) T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people

Jennifer Habel, Andrea Nguyen, Louise Rowntree, Christopher Szeto, Nicole Mifsud, E Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane W Nelson, Jane Davies, Adrian Miller, Steven YCT Tong, Jamie Rossjohn, Stephanie M Gras, Anthony Purcell, Luca M Hensen, Katherine Kedzierska, Patricia M Illing

Journal article  |  2022  |  PLOS PATHOGENS

HLA-A*11:01 is one of the most prevalent human leukocyte antigens (HLAs), especially in East Asian and Oceanian populations. It is..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K Allen, Tim Brahm, E Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nussing, Xiaoxiao Jia, Patrick Gunther, Adam K Wheatley, Stephen J Kent, Malet Aban, Yi-Mo Deng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one singl..

FOXO1 constrains activation and regulates senescence in CD8 T cells

Arnaud Delpoux, Nimi Marcel, Rodrigo Hess Michelini, Carol D Katayama, Karmel A Allison, Christopher K Glass, Sergio M Quinones-Parra, Cornelis Murre, Liyen Loh, Katherine Kedzierska, Martha Lappas, Stephen M Hedrick, Andrew L Doedens

Journal article  |  2021  |  CELL REPORTS

Naive and memory T cells are maintained in a quiescent state, yet capable of rapid response and differentiation to antigen challen..

High expression of CD38 and MHC class II on CD8( ) T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Y Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshansky, William R Heath, So Young Chang, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: Although co-expression of CD38 and HLA-DR reflects T-cell activation during viral infections, high and prolonged CD38+..

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

S Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin

Journal article  |  2020  |  NATURE COMMUNICATIONS

Most T lymphocytes leave the thymus as naïve cells with limited functionality. However, unique populations of innate-like T cells ..

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8( )T cells

Sneha Sant, Sergio M Quinones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2020  |  PLOS PATHOGENS

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell ..

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality (vol 11, 2857, 2020)

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  NATURE COMMUNICATIONS

An amendment to this paper has been published and can be accessed via a link at the top of the paper.