Liyen Loh

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.

S Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin

Journal article  |  2020  |  Nat Commun

Most T lymphocytes leave the thymus as naïve cells with limited functionality. However, unique populations of innate-like T cells ..

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8( )T cells

Sneha Sant, Sergio M Quinones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2020  |  PLOS PATHOGENS

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell ..

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality (vol 11, 2857, 2020)

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  NATURE COMMUNICATIONS

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Metabolic characteristics of CD8( ) T cell subsets in young and aged individuals are not predictive of functionality

Kylie M Quinn, Tabinda Hussain, Felix Kraus, Luke E Formosa, Wai K Lam, Michael J Dagley, Eleanor C Saunders, Lisa M Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E van de Sandt, Lucy Cooper, Kim L Good-Jacobson, Katherine Kedzierska, Laura K Mackay, Malcolm J McConville, Georg Ramm, Michael T Ryan, Nicole L La Gruta

Journal article  |  2020  |  NATURE COMMUNICATIONS

Virtual memory T (TVM) cells are antigen-naïve CD8+ T cells that exist in a semi-differentiated state and exhibit marked prolifera..

Monocyte apoptotic bodies are vehicles for influenza A virus propagation

Georgia K Atkin-Smith, Mubing Duan, Damien J Zanker, Liyen Loh, Thi HO Nguyen, Marios Koutsakos, Tien Nguyen, Xiangrui Jiang, Julio Carrera, Thanh Kha Phan, Chuanxin Liu, Stephanie Paone, Sara Oveissi, Amy L Hodge, Amy A Baxter, Katherine Kedzierska, Jason M Mackenzie, Mark D Hulett, Pamuk Bilsel, Weisan Chen, et al.

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

The disassembly of apoptotic cells into small membrane-bound vesicles termed apoptotic bodies (ApoBDs) is a hallmark of apoptosis;..

Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

Journal article  |  2020  |  ALLERGY

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and clas..

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey, et al.

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

Influenza A Virus-Infected Lung Epithelial Cell Co-Culture with Human Peripheral Blood Mononuclear Cells

Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Timothy SC Hinks

Journal article  |  2020  |  MAIT CELLS: METHODS AND PROTOCOLS

Sensing of influenza A virus (IAV) infection by pattern recognition receptors can occur by either direct infection of lung epithel..

Study of MAIT Cell Activation in Viral Infections In Vivo

Timothy SC Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2020  |  MAIT CELLS: METHODS AND PROTOCOLS

MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR)..

Multiplex Droplet Digital PCR Assay for Quantification of Human T-Cell Leukemia Virus Type 1 Subtype c DNA Proviral Load and T Cells from Blood and Respiratory Exudates Sampled in a Remote Setting

David Yurick, Georges Khoury, Bridle Clemens, Liyen Loh, Hai Pham, Katherine Kedzierska, Lloyd Einsiedel, Damian Purcell

Journal article  |  2019  |  JOURNAL OF CLINICAL MICROBIOLOGY

During human T-cell leukemia virus type 1 (HTLV-1) infection, the frequency of cells harboring an integrated copy of viral cDNA, t..