Amy Chung

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 (vol 13, 889372, 2022)

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale I Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy WW Chung, et al.

Journal article  |  2023  |  FRONTIERS IN IMMUNOLOGY

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Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil

Meseret W Kassa, Wina Hasang, Andre Barateiro, Timon Damelang, Jessica Brewster, Jamille GG Dombrowski, Rhea JJ Longley, Amy W Chung, Gerhard Wunderlich, Ivo Mueller, Elizabeth H Aitken, Claudio RF Marinho, Stephen JJ Rogerson

Journal article  |  2022  |  MALARIA JOURNAL

BACKGROUND: Pregnant women have increased susceptibility to Plasmodium falciparum malaria and acquire protective antibodies over s..

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian FJ Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, et al.

Journal article  |  2022  |  ISCIENCE

The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monocl..

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi HO Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson, et al.

Journal article  |  2022  |  PLOS PATHOGENS

Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their effi..

Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?

Chau Quang, Amy W Chung, Ian H Frazer, Zheng Quan Toh, Paul V Licciardi

Journal article  |  2022  |  TRENDS IN IMMUNOLOGY

A single dose of human papillomavirus (HPV) vaccine against HPV infection (prerequisite for cervical cancer) appears to be as effi..

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy W Chung, et al.

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain ..

Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain

Shidan Tosif, Ebene R Haycroft, Sohinee Sarkar, Zheng Quan Toh, Anh Ha Do Lien, Celeste M Donato, Kevin J Selva, Monsurul Hoq, Isabella Overmars, Jill Nguyen, Lai-Yang Lee, Vanessa Clifford, Andrew Daley, Francesa L Mordant, Jodie McVernon, Kim Mulholland, Adrian J Marcato, Miranda Z Smith, Nigel Curtis, Sarah McNab, et al.

Journal article  |  2022  |  PEDIATRIC ALLERGY AND IMMUNOLOGY

BACKGROUND: Household studies are crucial for understanding the transmission of SARS-CoV-2 infection, which may be underestimated ..

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Yi Ju, Wen Shi Lee, Emily H Pilkington, Hannah G Kelly, Shiyao Li, Kevin J Selva, Kathleen M Wragg, Kanta Subbarao, Thi HO Nguyen, Louise C Rowntree, Lilith F Allen, Katherine Bond, Deborah A Williamson, Nghia P Truong, Magdalena Plebanski, Katherine Kedzierska, Siddhartha Mahanty, Amy W Chung, Frank Caruso, Adam K Wheatley, et al.

Journal article  |  2022  |  ACS NANO

Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) m..

Insights into how SARS-CoV2 infection induces cytokine storms

Kevin John Selva, Amy W Chung

Journal article  |  2022  |  TRENDS IN IMMUNOLOGY

Severe coronavirus disease 2019 (COVID-19) has been associated with cytokine storms and hyperinflammation. In a recent study, Junq..

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

Wuji Zhang, Brendon Y Chua, Kevin J Selva, Lukasz Kedzierski, Thomas M Ashhurst, Ebene R Haycroft, Suzanne K Shoffner-Beck, Luca Hensen, David F Boyd, Fiona James, Effie Mouhtouris, Jason C Kwong, Kyra YL Chua, George Drewett, Ana Copaescu, Julie E Dobson, Louise C Rowntree, Jennifer R Habel, Lilith F Allen, Hui-Fern Koay, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral a..