Amy Chung

Decay of Fc-dependent antibody functions after mild to moderate COVID-19.

Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent

Journal article  |  2021  |  Cell Reports Medicine

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

Phillip Pymm, Amy Adair, Li-Jin Chan, James P Cooney, Francesca L Mordant, Cody C Allison, Ester Lopez, Ebene R Haycroft, Matthew T O'Neill, Li Lynn Tan, Melanie H Dietrich, Damien Drew, Marcel Doerflinger, Michael A Dengler, Nichollas E Scott, Adam K Wheatley, Nicholas A Gherardin, Hariprasad Venugopal, Deborah Cromer, Miles P Davenport, et al.

Journal article  |  2021  |  Proceedings of the National Academy of Sciences of the United States of America

Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVI..

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial.

Keith J Chappell, Francesca L Mordant, Zheyi Li, Danushka K Wijesundara, Paula Ellenberg, Julia A Lackenby, Stacey TM Cheung, Naphak Modhiran, Michael S Avumegah, Christina L Henderson, Kym Hoger, Paul Griffin, Jillian Bennet, Luca Hensen, Wuji Zhang, Thi HO Nguyen, Sara Marrero-Hernandez, Kevin J Selva, Amy W Chung, Mai H Tran, et al.

Journal article  |  2021  |  The Lancet Infectious Diseases

BACKGROUND: Given the scale of the ongoing COVID-19 pandemic, the development of vaccines based on different platforms is essentia..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi, et al.

Journal article  |  2021  |  Nature Communications

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley, et al.

Journal article  |  2021  |  CELL REPORTS MEDICINE

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung, et al.

Journal article  |  2021  |  Nature Communications

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

Antibody mediated activation of natural killer cells in malaria exposed pregnant women

Timon Damelang, Elizabeth H Aitken, Wina Hasang, Ester Lopez, Martin Killian, Holger W Unger, Ali Salanti, Alexis Shub, Elizabeth McCarthy, Katherine Kedzierska, Martha Lappas, Stephen J Kent, Stephen J Rogerson, Amy W Chung

Journal article  |  2021  |  Scientific Reports

Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can ind..

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao, et al.

Journal article  |  2021  |  Clinical and Translational Immunology

Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, Sohinee Sarkar, Kevin J Selva, Anh Ha Do Lien, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Katie L Flanagan, Kelly B Arnold, Francesca L Mordant, Kim Mulholland, Julie Bines, Kate Dohle, et al.

Journal article  |  2020  |  Nature Communications

Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptom..

Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

M Muenchhoff, AW Chung, J Roider, Anne-Sophie Dugast, Simone Richardson, Henrik Kloverpris, Alasdair Leslie, Thumbi Ndung'u, Penny Moore, Galit Alter, Philip JR Goulder

Journal article  |  2020  |  mSphere

A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing a..