Rebecca M. Nisbet

Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy

Rinie Bajracharya, Esteban Cruz, Jurgen Gotz, Rebecca M Nisbet

Journal article  |  2022  |  JOURNAL OF CONTROLLED RELEASE

Tau-specific immunotherapy is an attractive strategy for the treatment of Alzheimer's disease and other tauopathies. However, effe..

Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain

Rinie Bajracharya, Alayna C Caruso, Laura J Vella, Rebecca M Nisbet

Journal article  |  2021  |  PHARMACEUTICS

For the treatment of neurological diseases, achieving sufficient exposure to the brain parenchyma is a critical determinant of dru..

Citrullination of Amyloid-beta Peptides in Alzheimer's Disease

Soumya Mukherjee, Keyla A Perez, Celine Dubois, Rebecca M Nisbet, Qiao-Xin Li, Shiji Varghese, Liang Jin, Ian Birchall, Victor A Streltsov, Laura J Vella, Catriona McLean, Kevin J Barham, Blaine R Roberts, Colin L Masters

Journal article  |  2021  |  ACS CHEMICAL NEUROSCIENCE

Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullinatio..

Residues Surrounding the Glycosylphosphatidylinositol Anchor Attachment Site of PrP Modulate Prion Infection: Insight from the Resistance of Rabbits to Prion Disease

Rebecca M Nisbet, Christopher F Harrison, Victoria A Lawson, Colin L Masters, Roberto Cappai, Andrew F Hill

Journal article  |  2010  |  JOURNAL OF VIROLOGY

Prion diseases are a group of transmissible, invariably fatal neurodegenerative diseases that affect both humans and animals. Acco..

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

Robyn A Sharples, Laura J Vella, Rebecca M Nisbet, Ryan Naylor, Keyla Perez, Kevin J Barnham, Colin L Masters, Andrew F Hill

Journal article  |  2008  |  FASEB JOURNAL

Alzheimer's disease (AD) is the most common form of dementia and is associated with the deposition of the 39- to 43-amino acid bet..