Martin Pera

A path to translation: How 3D patient tumor avatars enable next generation precision oncology.

undefined Shree Bose, Margarida Barroso, Milan G Chheda, Hans Clevers, Elena Elez, Salma Kaochar, Scott E Kopetz, Xiao-Nan Li, Funda Meric-Bernstam, Clifford A Meyer, Haiwei Mou, Kristen M Naegle, Martin F Pera, Zinaida Perova, Katerina A Politi, Benjamin J Raphael, Paul Robson, Rosalie C Sears, Josep Tabernero, David A Tuveson, et al.

Journal article  |  2022  |  Cancer Cell

3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challen..

The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells.

Peter W Andrews, Ivana Barbaric, Nissim Benvenisty, Jonathan S Draper, Tenneille Ludwig, Florian T Merkle, Yoji Sato, Claudia Spits, Glyn N Stacey, Haoyi Wang, Martin F Pera

Journal article  |  2022  |  Cell Stem Cell

It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and epigenetic changes during culture in vitr..

Why it is important to study human-monkey embryonic chimeras in a dish.

Alejandro De Los Angeles, Alan Regenberg, Victoria Mascetti, Nissim Benvenisty, George Church, Hongkui Deng, Juan Carlos Izpisua Belmonte, Weizhi Ji, Julian Koplin, Yuin-Han Loh, Yuyu Niu, Duanqing Pei, Martin Pera, Nam Pho, Carlos Pinzon-Arteaga, Mitinori Saitou, Jose CR Silva, Tan Tao, Alan Trounson, Tushar Warrier, et al.

Journal article  |  2022  |  Nat Methods

The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance an..

Pluripotent cell states and unexpected fates.

Martin F Pera

Journal article  |  2022  |  Stem Cell Reports

Pluripotent stem cells provide a powerful model for the study of human development and its disorders. Recent studies, including tw..

A Splicing Mutation in Slc4a5 Results in Retinal Detachment and Retinal Pigment Epithelium Dysfunction.

Gayle B Collin, Lanying Shi, Minzhong Yu, Nurten Akturk, Jeremy R Charette, Lillian F Hyde, Sonia M Weatherly, Martin F Pera, Jürgen K Naggert, Neal S Peachey, Patsy M Nishina, Mark P Krebs

Journal article  |  2022  |  Int J Mol Sci

Fluid and solute transporters of the retinal pigment epithelium (RPE) are core components of the outer blood-retinal barrier. Char..

Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors.

Arup R Chakraborty, Alex Vassilev, Sushil K Jaiswal, Constandina E O'Connell, John F Ahrens, Barbara S Mallon, Martin F Pera, Melvin L DePamphilis

Journal article  |  2022  |  Stem Cell Reports

Inhibition of PIKfyve phosphoinositide kinase selectively kills autophagy-dependent cancer cells by disrupting lysosome homeostasi..

The exploration of pluripotency space: Charting cell state transitions in peri-implantation development

Martin F Pera, Janet Rossant

Journal article  |  2021  |  CELL STEM CELL

Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in patterns of gene expression and developme..

Updates for contributors: Rigor and reproducibility in stem cell research.

Martin Pera

Journal article  |  2021  |  Stem Cell Reports

Biomedical and societal impacts of in vitro embryo models of mammalian development.

Naomi Moris, Cantas Alev, Martin Pera, Alfonso Martinez Arias

Journal article  |  2021  |  Stem Cell Reports

In recent years, a diverse array of in vitro cell-derived models of mammalian development have been described that hold immense po..

A case for revisiting Nodal signaling in human pluripotent stem cells

Kevin Hayes, Yun-Kyo Kim, Martin F Pera

Journal article  |  2021  |  STEM CELLS

Nodal is a transforming growth factor-β (TGF-β) superfamily member that plays a number of critical roles in mammalian embryonic de..