Prof Leann Tilley
Honorary (Redmond Barry Distinguished Professor Emeritus)
Department of Biochemistry and Pharmacology
284 Scholarly works
40 Projects
HIGHLIGHTS
2019
Journal article
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
DOI: 10.1038/s41564-019-0524-42019
Research Grant
Nucleoside Sulphamates as Novel Antimalarials for the Treatment of Plasmodium Falciparum
2017
Journal article
Erythrocyte β spectrin can be genetically targeted to protect mice from malaria
DOI: 10.1182/bloodadvances.20170092742017
Research Grant
H2017-101 – HTL for Selective Plasmodium Proteasome Inhibitors as New Potent Resistance-Reversing Antimalarials.
2017
Research Grant
A Collaborative Electron Microscopy Pipeline for Structural Biology (Non-Arc Cash)
2012
Journal article
Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum
DOI: 10.1016/j.jsb.2011.09.0032012
Journal article
Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum
DOI: 10.1016/j.jsb.2011.09.003
RECENT SCHOLARLY WORKS
2026
Journal article
Reaction hijacking of enzymes to generate potent therapeutic modulators in situ.
DOI: 10.1016/j.tibs.2026.03.0032025
Journal article
Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
DOI: 10.1371/journal.ppat.10130572025
Conference Proceedings
Understanding the drug resistance in the malaria parasite Plasmodium falciparum through high resolution imaging
DOI: 10.14293/apmc13-2025-00852024
Journal article
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo
DOI: 10.1371/journal.ppat.10124292024
Journal article
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
DOI: 10.1038/s41467-024-45224-z2024
Journal article
Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus
DOI: 10.1038/s41467-024-50167-62023
Journal article
Plasmodium falciparum formins are essential for invasion and sexual stage development
DOI: 10.1038/s42003-023-05233-y2023
Journal article
Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development
DOI: 10.1146/annurev-micro-032421-121210