Prof. Richard Pearson
Honorary
The Sir Peter Maccallum Department of Oncology
147 Scholarly works
22 Projects
HIGHLIGHTS
2018
Journal article
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
DOI: 10.1038/s41467-018-05564-z2015
Journal article
The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma
DOI: 10.1126/scisignal.aab11112014
Journal article
Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis
DOI: 10.1158/2159-8290.CD-13-04402014
Research Grant
ONCOGENIC SIGNALING AND CANCER THERAPY
2013
Research Grant
ESTABLISHMENT OF ACRF ADVANCED CENTRE FOR CANCER CELL ISOLATION AND IMAGING
2013
Research Grant
Targetting deregulated signalling pathways in high-grade serous ovarian cancer: Defining therapeutic response and mechanisms of resistance
2011
Journal article
Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone
DOI: 10.1371/journal.pgen.1002408
RECENT SCHOLARLY WORKS
2021
Journal article
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
DOI: 10.1038/s41392-021-00728-82021
Journal article
CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition.
DOI: 10.1158/1535-7163.MCT-20-09322021
Journal article
Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death
DOI: 10.1182/blood.20200074522020
Journal article
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer
DOI: 10.1038/s41416-020-01158-z2020
Journal article
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
DOI: 10.15252/embj.20201051112020
Journal article
CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer
DOI: 10.1080/23723556.2020.18052562020
Journal article
Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression
DOI: 10.1158/0008-5472.CAN-19-39142020
Journal article
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461
DOI: 10.3389/fcell.2020.00568