Dr. Amanda Edgley
Research Fellow
Medicine - St Vincent's Hospital
67 Scholarly works
17 Projects
HIGHLIGHTS
2021
Journal article
RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis
DOI: 10.1016/j.ijcard.2020.10.0352021
Journal article
β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat.
DOI: 10.1042/CS202014412021
Journal article
RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome
DOI: 10.1016/j.ijcard.2020.09.0212021
Journal article
beta-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat
DOI: 10.1042/CS202014412020
Research Grant
In vivo evaluation of a novel ketone sensor
2020
Research Contracts
The effect of CERTA next generation antifibrotic compounds on collagen synthesis and cellular proliferation in cultured renal mesangial cells
2018
Research Contracts
Testing efficacy of low dose OCX063, OCX071 and FT011 on albuminuria in Ren2 rat model of diabetes [2018-OCX-PC-10]
RECENT SCHOLARLY WORKS
2020
Journal article
RE: ASK1, a new target in treating cardiorenal syndrome (CRS)
DOI: 10.1016/j.ijcard.2020.05.0502020
Journal article
Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome
DOI: 10.1016/j.ijcard.2020.04.0152019
Journal article
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model
DOI: 10.1016/j.yjmcc.2019.10.0052019
Journal article
P3493Uremic toxin induced endothelial dysfunction can be restored by inhibition of the aryl hydrocarbon receptor: implications for cardiovascular disease treatment in chronic kidney disease patients
DOI: 10.1093/eurheartj/ehz745.03602019
Conference Proceedings
Uremic toxin induced endothelial dysfunction can be restored by inhibition of the aryl hydrocarbon receptor: implications for cardiovascular disease treatment in chronic kidney disease patients
2019
Conference Proceedings
Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model
2018
Journal article
Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model
DOI: 10.1161/JAHA.117.0074512018
Conference Proceedings
Changes in titin phosphorylation and PKG activity underlie diastolic dysfunction at the cross-bridge level in the early stages of type 2 diabetes