A/Prof Ruth Kluck
Honorary Principal Fellow
Faculty of Medicine, Dentistry and Health Sciences
86 Scholarly works
0 Projects
HIGHLIGHTS
2025
Journal article
Computational design of potent and selective binders of BAK and BAX
DOI: 10.1126/sciadv.adt41702025
Journal article
Abstract 1382: The discovery of a novel antibody, 14G6, as a tool for understanding BAK conformational dynamics and their relationship to venetoclax response in leukemia
DOI: 10.1158/1538-7445.am2025-13822024
Journal article
A lipid signature of BAK-driven apoptotic pore formation.
DOI: 10.1101/2024.10.16.6185702024
Journal article
Correction: John F. R. Kerr (1934–2024): Apoptosis: a basic biological phenomenon (Cell Death & Differentiation, (2024), 31, 8, (955-956), 10.1038/s41418-024-01338-x)
DOI: 10.1038/s41418-024-01373-82024
Journal article
John F. R. Kerr (1934-2024) : Apoptosis: a basic biological phenomenon
DOI: 10.1038/s41418-024-01338-x2024
Journal article
A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells
DOI: 10.1038/s41418-024-01289-32021
Journal article
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
DOI: 10.1182/blood.2020010167
RECENT SCHOLARLY WORKS
2023
Journal article
The crystal structure of detergent-activated BAK dimers provides insights into BAK activation steps and how they stabilise membrane pores
DOI: 10.1107/s205327332308912x2023
Journal article
Structure of the BAK- inhibiting antibody 14G6 bound to BAK identifies core–latch separation and α1-dissociation as essential events in BAK activation
DOI: 10.1107/s20532733230867092023
Journal article
Apoptotic cell death in disease—Current understanding of the NCCD 2023
DOI: 10.1038/s41418-023-01153-w2023
Journal article
Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs
DOI: 10.1038/s41418-023-01117-0