Prof Guillaume Lessene
Honorary (Professorial Fellow)
Department of Medical Biology (WEHI)
116 Scholarly works
0 Projects
HIGHLIGHTS
2023
Journal article
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia
DOI: 10.1182/blood.20220160902020
Journal article
Cotargeting BCL-2 and MCL-1 in high-risk B-ALL
DOI: 10.1182/bloodadvances.20190014162019
Journal article
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations
DOI: 10.1038/s41467-019-10363-12019
Journal article
Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia
DOI: 10.1038/s41375-018-0261-32018
Journal article
BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines
DOI: 10.1016/j.ccell.2018.11.0042018
Journal article
Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1
DOI: 10.1038/leu.2017.2432016
Journal article
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
DOI: 10.1038/nature19830
RECENT SCHOLARLY WORKS
2025
Journal article
Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity
DOI: 10.1371/journal.ppat.10134682025
Journal article
Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins
DOI: 10.1038/s41418-025-01487-72025
Journal article
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
DOI: 10.1126/sciadv.adr81462025
Journal article
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
DOI: 10.1038/s41467-025-57905-42024
Journal article
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape
DOI: 10.1038/s41467-024-50566-92024
Journal article
Improved drug target deconvolution with PISA-DIA using an extended, overlapping temperature gradient
DOI: 10.1002/pmic.2023006442024
Journal article
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis
DOI: 10.1371/journal.pbio.30026172023
Journal article
Dissecting the RIPK3/MLKL necroptotic molecular switch
DOI: 10.1107/s2053273323087788