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Contact


Email

jsilke@unimelb.edu.au

Credentials


Position
Honorary (Professorial Fellow)
Department of Medical Biology (WEHI)
Education
PhD
University of Zurich
Bachelors Degree (Honours)
University of Cambridge
Bachelors Degree
King's College London
ORCID

0000-0002-7611-5774

Prof John Silke

Honorary (Professorial Fellow)
Department of Medical Biology (WEHI)

289 Scholarly works
1 Projects

HIGHLIGHTS

  • 2026

    Journal article

    Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors
    DOI: 10.1038/s42004-025-01871-x
  • 2026

    Journal article

    The PANoptosis hypothesis examined.
    DOI: 10.1038/s41580-026-00970-4
  • 2026

    Journal article

    IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes
    DOI: 10.1016/j.chembiol.2026.03.005
  • 2026

    Journal article

    The kinase domain of RIPK3 tunes its scaffolding functions
    DOI: 10.1038/s41418-026-01677-x
  • 2025

    Journal article

    SIX of one and half-a-dozen USP2 regulating inflammation
    DOI: 10.1038/s41422-025-01173-w
  • 2025

    Journal article

    Enabling high-resolution diagnostic oral confocal laser endomicroscopy in mice
    DOI: 10.1016/j.ymeth.2025.04.015
  • 2014

    Journal article

    RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
    DOI: 10.1016/j.cell.2014.04.019
John Silke

Latest Honours,
Awards and Fellowships


2016
NHMRC Fellowship (NHMRCF)
2015
2015 Citation & Innovation Award Thomson Reuters Australia

RECENT SCHOLARLY WORKS

  • 2025

    Journal article

    The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro
    DOI: 10.26508/lsa.202503243
  • 2025

    Journal article

    AXIN2 is a non-redundant regulator of AXIN1 stability and β-catenin in colorectal cancer cells
    DOI: 10.1111/febs.17336
  • 2025

    Journal article

    Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy
    DOI: 10.1038/s41598-025-86400-5
  • 2024

    Journal article

    Intracellular zinc protects tumours from T cell-mediated cytotoxicity
    DOI: 10.1038/s41418-024-01369-4

RECENT PROJECTS

  • 2016

    Internal Research Grant

    Targeting TWEAK/Fn14 Signalling to Treat Cardiac Cachexia in Cancer

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