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Email

jsilke@unimelb.edu.au

Credentials


Position
Honorary Professorial Fellow
Faculty of Medicine, Dentistry and Health Sciences - Admin
Education
PhD
University of Zurich
Bachelors Degree (Honours)
University of Cambridge
Bachelors Degree
King's College London
ORCID

0000-0002-7611-5774

Prof John Silke

Honorary Professorial Fellow
Faculty of Medicine, Dentistry and Health Sciences

206 Scholarly works
0 Projects

HIGHLIGHTS

  • 2026

    Journal article

    Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors
    DOI: 10.1038/s42004-025-01871-x
  • 2026

    Journal article

    ANCHR regulates TRAIL-mediated apoptosis with implications for liver injury
    DOI: 10.1016/j.heliyon.2026.e45090
  • 2026

    Journal article

    Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and Candida escape.
    DOI: 10.1038/s41467-026-74195-6
  • 2026

    Journal article

    The benchmarking and application of tag-degraders in vivo to validate therapeutic targets.
    DOI: 10.1038/s41467-026-73681-1
  • 2026

    Journal article

    The transmembrane domain structure of TNFR1 suppresses ligand-independent autoactivation but is not required for TNF-induced signaling
    DOI: 10.1126/scisignal.adz0203
  • 2026

    Journal article

    IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes
    DOI: 10.1016/j.chembiol.2026.03.005
  • 2014

    Journal article

    RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
    DOI: 10.1016/j.cell.2014.04.019
John Silke

Latest Honours,
Awards and Fellowships


2016
NHMRC Fellowship (NHMRCF)
2015
2015 Citation & Innovation Award Thomson Reuters Australia

RECENT SCHOLARLY WORKS

  • 2026

    Journal article

    The PANoptosis hypothesis examined
    DOI: 10.1038/s41580-026-00970-4
  • 2026

    Journal article

    Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse
    DOI: 10.1111/jop.70145
  • 2026

    Journal article

    Reply to ‘Single-cell evidence for PANoptosome complexes’
    DOI: 10.1038/s41580-026-00995-9
  • 2025

    Journal article

    The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro
    DOI: 10.26508/lsa.202503243

Acknowledgement of Country

We acknowledge Aboriginal and Torres Strait Islander people as the Traditional Owners of the unceded lands on which we work, learn and live. We pay respect to Elders past, present and future, and acknowledge the importance of Indigenous knowledge in the Academy.

Read about our Indigenous priorities

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