Dr Chris Bye
Honorary (Senior Fellow)
Florey Department of Neuroscience and Mental Health
39 Scholarly works
4 Projects
HIGHLIGHTS
2026
Journal article
Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy
DOI: 10.1038/s41593-025-02118-72024
Research grants (ARC, NHMRC, MRFF)
Accelerated Drug Discovery Using Population Wide Screening of Patient iPSC\2019s for MND
2023
Research Grant
Functional Neuromuscular Organoids: The Next Generation of Cell-Based Models for Finding MND Therapeutics
2022
Journal article
Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
DOI: 10.1186/s13073-021-01006-62022
Journal article
α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis
DOI: 10.1093/braincomms/fcac0812020
Journal article
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
DOI: 10.1016/j.cell.2020.09.0202020
Journal article
Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
DOI: 10.1016/j.stem.2020.01.010
RECENT SCHOLARLY WORKS
2019
Journal article
Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain
DOI: 10.1016/j.stemcr.2019.10.0012019
Journal article
Axonal growth of midbrain dopamine neurons is modulated by the cell adhesion molecule ALCAM through trans-heterophilic interactions with l1cam, Chl1, and semaphorins
DOI: 10.1523/JNEUROSCI.0278-19.20192018
Journal article
Association of regulatory T-Cell Expansion with progression of amyotrophic lateral sclerosis a study of humans and a transgenic mouse model
DOI: 10.1001/jamaneurol.2018.00352017
Journal article
Specification of murine ground state pluripotent stem cells to regional neuronal populations
DOI: 10.1038/s41598-017-16248-x2017
Journal article
Efficiently specified ventral midbrain dopamine neurons from human pluripotent stem cells under Xeno-free conditions restore motor deficits in Parkinsonian rodents
DOI: 10.5966/sctm.2016-0073
RECENT PROJECTS
2013
Research Grant
Modelling the Effect of Protein Transmission in Parkinson's Disease in the A53t Alpha-Synuclein Mouse.
2014
Internal Research Grant
Transmission of a-Synuclein Pathology in Parkinsons Disease