Contact

Email

a.christopoulos@unimelb.edu.au

Credentials

Position

Biochemistry and Pharmacology
Education
Doctor of Philosophy
Monash University
Bachelor of Pharmacy
Monash University

Dr. Arthur Christopoulos

Honorary
Biochemistry and Pharmacology
47 Scholarly works
9 Projects

HIGHLIGHTS

  • 2020

    Journal article

    Acetylcholine Muscarinic M-4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents
    DOI: 10.1016/j.biopsych.2020.02.019
  • 2020

    Journal article

    Structure and dynamics of the active Gs-coupled human secretin receptor.
    DOI: 10.1038/s41467-020-17791-4
  • 2019

    Journal article

    Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.
    DOI: 10.1021/acschembio.9b00342
  • 2019

    Journal article

    6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M-1 mAChR: The Determinants of Allosteric Activity
    DOI: 10.1021/acschemneuro.8b00613
  • 2019

    Journal article

    Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D2 Receptor.
    DOI: 10.1021/acs.jmedchem.8b00192
  • 2018

    Conference Proceedings

    ML375 A NOVEL NEGATIVE ALLOSTERIC MODULATOR (NAM) OF (M-5) MUSCARINIC RECEPTOR (MACHR) ATTENUATES ALCOHOL DRINKING AND SEEKING IN GENETICALLY SELECTED IP RATS THROUGH MODULATION OF DORSOLATERAL STRIATUM M5 RECEPTORS
  • 2018

    Journal article

    Structural insights into G-protein-coupled receptor allostery
    DOI: 10.1038/s41586-018-0259-z
Arthur Christopoulos

RECENT SCHOLARLY WORKS

  • 2018

    Journal article

    Muscarinic M-5 receptors modulate ethanol seeking in rats
    DOI: 10.1038/s41386-017-0007-3
  • 2018

    Journal article

    Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex
    DOI: 10.1038/nature25773
  • 2017

    Journal article

    THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
    DOI: 10.1111/bph.13882
  • 2006

    Journal article

    A critical role for the short intracellular C terminus in receptor activity-modifying protein function
    DOI: 10.1124/mol.106.024257
  • 2006

    Journal article

    Interaction studies of multiple binding sites on M-4 muscarinic acetylcholine receptors
    DOI: 10.1124/mol.106.024711
  • 2006

    Journal article

    Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors
    DOI: 10.1124/mol.105.021915
  • 2006

    Journal article

    Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M-1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist
    DOI: 10.1124/mol.105.017814
  • 2005

    Journal article

    Effects of urea pretreatment on the binding properties of adenosine A(1) receptors
    DOI: 10.1038/sj.bjp.0706419