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Email

jhildebrand@unimelb.edu.au

Credentials


Position

Medical Biology (W.E.H.I.)
Education
PhD-Medicine, Dentistry & Health Sciences
University of Melbourne
Science
University of Melbourne
Biomedical Science
University of Melbourne

Dr. Joanne Hildebrand

Honorary
Medical Biology (W.E.H.I.)

30 Scholarly works
0 Projects

HIGHLIGHTS

  • 2021

    Journal article

    The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis.
    DOI: 10.1038/s41419-021-03418-z
  • 2020

    Journal article

    Necroptotic movers and shakers: cell types, inflammatory drivers and diseases.
    DOI: 10.1016/j.coi.2020.09.008
  • 2020

    Journal article

    Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway
    DOI: 10.1021/acschembio.0c00482
  • 2020

    Journal article

    MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
    DOI: 10.1038/s41467-020-16887-1
  • 2020

    Journal article

    A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
    DOI: 10.1038/s41467-020-16819-z
  • 2020

    Journal article

    Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
    DOI: 10.1073/pnas.1919960117
  • 2019

    Journal article

    A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs (vol 9, pg 4457, 2018)
    DOI: 10.1038/s41467-019-09536-9
Joanne Hildebrand

Latest Honours,
Awards and Fellowships


2003
NHMRC Dora Lush Postgraduate Scholarship
2018
NHMRCF - NHMRC Fellowship
2009
CJMARTIN - C.J. Martin Research Fellowship (National Health & Medical Research Council, Australia)

RECENT SCHOLARLY WORKS

  • 2018

    Journal article

    A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
    DOI: 10.1038/s41467-018-06985-6
  • 2018

    Journal article

    Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
    DOI: 10.1038/s41467-018-04714-7
  • 2018

    Journal article

    Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted
    DOI: 10.1038/s41418-017-0031-1
  • 2018

    Journal article

    Methods for Studying TNF-Mediated Necroptosis in Cultured Cells
    DOI: 10.1007/978-1-4939-8754-2_5
  • 2017

    Journal article

    EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
    DOI: 10.1038/nmicrobiol.2016.258
  • 2017

    Journal article

    Combination of IAP antagonist and IFN gamma activates novel caspase-10-and RIPK1-dependent cell death pathways
    DOI: 10.1038/cdd.2016.147
  • 2017

    Journal article

    Insane in the membrane: a structural perspective of MLKL function in necroptosis
    DOI: 10.1038/icb.2016.125
  • 2017

    Journal article

    Synaptic Zn2 and febrile seizure susceptibility
    DOI: 10.1111/bph.13658

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