Dr Rachel Uren
Honorary (Fellow)
Department of Medical Biology (WEHI)
25 Scholarly works
0 Projects
HIGHLIGHTS
2025
Journal article
Computational design of potent and selective binders of BAK and BAX
DOI: 10.1126/sciadv.adt41702025
Journal article
Abstract 1382: The discovery of a novel antibody, 14G6, as a tool for understanding BAK conformational dynamics and their relationship to venetoclax response in leukemia
DOI: 10.1158/1538-7445.am2025-13822024
Journal article
A lipid signature of BAK-driven apoptotic pore formation.
DOI: 10.1101/2024.10.16.6185702024
Journal article
Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids
DOI: 10.1111/febs.170312024
Journal article
A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells
DOI: 10.1038/s41418-024-01289-32023
Journal article
The crystal structure of detergent-activated BAK dimers provides insights into BAK activation steps and how they stabilise membrane pores
DOI: 10.1107/s205327332308912x2023
Journal article
Structure of the BAK- inhibiting antibody 14G6 bound to BAK identifies core–latch separation and α1-dissociation as essential events in BAK activation
DOI: 10.1107/s2053273323086709
RECENT SCHOLARLY WORKS
2022
Journal article
The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK
DOI: 10.15252/embj.20211103002022
Journal article
NAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells
DOI: 10.1080/19420862.2022.21066212021
Journal article
Structure of detergent-activated BAK dimers derived from the inert monomer
DOI: 10.1016/j.molcel.2021.03.014