Dr. Leila Varghese
Curation Scientist
Clinical Pathology
15 Scholarly works
0 Projects
HIGHLIGHTS
2021
Journal article
CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag.
DOI: 10.1182/blood.20200105672021
Journal article
A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline.
DOI: 10.1038/s41375-021-01239-92020
Journal article
MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491
DOI: 10.1182/blood.20190032402020
Journal article
MPL membrane domain sequencing goes deep
DOI: 10.1182/blood.20190034822019
Journal article
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome (vol 36, pg 123, 2019)
DOI: 10.1016/j.ccell.2019.08.0142019
Journal article
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome
DOI: 10.1016/j.ccell.2019.06.0072019
Journal article
The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications
DOI: 10.1080/17474086.2019.1617129
RECENT SCHOLARLY WORKS
2017
Journal article
The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin
DOI: 10.3389/fendo.2017.000592016
Journal article
An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L
DOI: 10.1182/blood-2016-067220582015
Journal article
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
DOI: 10.1042/BJ20150678