Dr Richard Birkinshaw
Honorary (Fellow)
Department of Medical Biology (WEHI)
49 Scholarly works
0 Projects
HIGHLIGHTS
2026
Journal article
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
DOI: 10.1016/j.cell.2026.01.0292026
Journal article
MK-7602: a potent multi-stage dual-targeting antimalarial
DOI: 10.1016/j.ebiom.2025.1060612025
Journal article
Computational design of potent and selective binders of BAK and BAX
DOI: 10.1126/sciadv.adt41702020
Journal article
Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax
DOI: 10.1182/BLOOD.20190042052019
Journal article
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations
DOI: 10.1038/s41467-019-10363-12019
Journal article
Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma
DOI: 10.1111/bjh.160692019
Journal article
Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia
DOI: 10.1158/2159-8290.CD-18-1119
RECENT SCHOLARLY WORKS
2025
Journal article
Resistance to targeted therapies in chronic lymphocytic leukemia: Current status and perspectives for clinical and diagnostic practice
DOI: 10.1038/s41375-025-02662-y2025
Journal article
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
DOI: 10.1126/sciadv.adr81462025
Journal article
Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia
DOI: 10.1182/bloodadvances.20240144462025
Journal article
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
DOI: 10.1038/s41467-025-57905-42024
Journal article
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis
DOI: 10.1371/journal.pbio.30026172023
Journal article
The crystal structure of detergent-activated BAK dimers provides insights into BAK activation steps and how they stabilise membrane pores
DOI: 10.1107/s205327332308912x2022
Journal article
Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation
DOI: 10.1038/s41418-022-00961-w