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Email

sc.xie@unimelb.edu.au

Credentials


Position
Honorary (Fellow)
Department of Biochemistry and Pharmacology
Education
PhD
University of Melbourne
Bachelors Degree (Honours)
University of Sydney
Bachelors Degree
Adelaide University
ORCID

0000-0001-7003-4677

Dr Stanley Xie

Honorary (Fellow)
Department of Biochemistry and Pharmacology

27 Scholarly works
2 Projects

HIGHLIGHTS

  • 2026

    Journal article

    Reaction hijacking of enzymes to generate potent therapeutic modulators in situ.
    DOI: 10.1016/j.tibs.2026.03.003
  • 2025

    Journal article

    Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
    DOI: 10.1371/journal.ppat.1013057
  • 2025

    Thesis / Dissertation

    Reaction hijacking inhibition of tRNA charging enzymes in Plasmodium and bacteria
  • 2024

    Journal article

    A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo
    DOI: 10.1371/journal.ppat.1012429
  • 2023

    Research grants (ARC, NHMRC, MRFF)

    Hijacking Adenylate-Forming Enzymes: A New Strategy for Development of Anti-Infectives
  • 2019

    Journal article

    The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
    DOI: 10.1038/s41564-019-0524-4
  • 2016

    Research Contracts

    Participation as a Visiting Scientist -Opportunity to Participate as a Visiting Scientist in Certain Scientific Activities of Millennium Pharmaceuticals, Inc., a Wholly Owned Subsidiary of Takeda Pharmaceutical Company Limited,
Stanley Xie

RECENT SCHOLARLY WORKS

  • 2024

    Journal article

    Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
    DOI: 10.1038/s41467-024-45224-z
  • 2023

    Journal article

    Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development
    DOI: 10.1146/annurev-micro-032421-121210
  • 2023

    Journal article

    Hijacking tRNA charging process: a novel approach to combat malaria
    DOI: 10.1107/s2053273323089076
  • 2022

    Journal article

    Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
    DOI: 10.1126/science.abn0611
  • 2021

    Journal article

    Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome
    DOI: 10.1073/pnas.2107213118
  • 2021

    Journal article

    High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials
    DOI: 10.1021/acsinfecdis.1c00110
  • 2020

    Journal article

    K13, the Cytostome, and Artemisinin Resistance
    DOI: 10.1016/j.pt.2020.03.006

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