Dr Stanley Xie
Honorary (Fellow)
Department of Biochemistry and Pharmacology
27 Scholarly works
2 Projects
HIGHLIGHTS
2026
Journal article
Reaction hijacking of enzymes to generate potent therapeutic modulators in situ.
DOI: 10.1016/j.tibs.2026.03.0032025
Journal article
Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target
DOI: 10.1371/journal.ppat.10130572025
Thesis / Dissertation
Reaction hijacking inhibition of tRNA charging enzymes in Plasmodium and bacteria
2024
Journal article
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo
DOI: 10.1371/journal.ppat.10124292023
Research grants (ARC, NHMRC, MRFF)
Hijacking Adenylate-Forming Enzymes: A New Strategy for Development of Anti-Infectives
2019
Journal article
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
DOI: 10.1038/s41564-019-0524-42016
Research Contracts
Participation as a Visiting Scientist -Opportunity to Participate as a Visiting Scientist in Certain Scientific Activities of Millennium Pharmaceuticals, Inc., a Wholly Owned Subsidiary of Takeda Pharmaceutical Company Limited,
RECENT SCHOLARLY WORKS
2024
Journal article
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
DOI: 10.1038/s41467-024-45224-z2023
Journal article
Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development
DOI: 10.1146/annurev-micro-032421-1212102023
Journal article
Hijacking tRNA charging process: a novel approach to combat malaria
DOI: 10.1107/s20532733230890762022
Journal article
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
DOI: 10.1126/science.abn06112021
Journal article
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome
DOI: 10.1073/pnas.21072131182021
Journal article
High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials
DOI: 10.1021/acsinfecdis.1c001102020
Journal article
K13, the Cytostome, and Artemisinin Resistance
DOI: 10.1016/j.pt.2020.03.006