Prof Isabelle Rouiller
Professor (Structural Biologist)
Department of Biochemistry and Pharmacology
79 Scholarly works
20 Projects
HIGHLIGHTS
2026
Journal article
Biolayer Interferometry for Investigating Membrane Protein-Inhibitor Binding: TACAN Mutant and GsMTx4 As a Model System
DOI: 10.3791/693482026
Journal article
Bringing the ends together: Cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis
DOI: 10.1093/nar/gkaf14182025
Journal article
Lysine acetylation modulates s-OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling
DOI: 10.1002/pro.701792024
Journal article
Molecular Mechanism of Processing Ubiquitinated Substrates by p97 and Its Main Cofactors
DOI: 10.20944/preprints202409.1194.v12023
Research grants (ARC, NHMRC, MRFF)
RNA Powered Antiviral Antibodies
2021
Research Grant
Hydrogen-Deuterium Exchange System - a Missing Link in Protein Analysis
2021
Research grants (ARC, NHMRC, MRFF)
ARC Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery (CCeMMP)
RECENT SCHOLARLY WORKS
2024
Journal article
Analysis of the Conformational Landscape of the N-Domains of the AAA ATPase p97: Disentangling the Continuous Conformational Variability in Partially Symmetrical Complexes
DOI: 10.3390/ijms250633712024
Journal article
In silico and in vitro characterization of the mycobacterial protein Ku to unravel its role in non-homologous end-joining DNA repair
DOI: 10.1016/j.ijbiomac.2024.1345842023
Journal article
MDTOMO method for continuous conformational variability analysis in cryo electron subtomograms based on molecular dynamics simulations
DOI: 10.1038/s41598-023-37037-92023
Journal article
Structure–function insight into the two-component DNA repair system of Mycobacterium tuberculosis
DOI: 10.1107/s20532733230892092023
Journal article
Understanding the conformational landscape of a protein complex from cryo-EM and mass spectrometry data
DOI: 10.1107/s20532733230936462023
Journal article
MDSPACE: Extracting Continuous Conformational Landscapes from Cryo-EM Single Particle Datasets Using 3D-to-2D Flexible Fitting based on Molecular Dynamics Simulation
DOI: 10.1016/j.jmb.2023.167951
RECENT PROJECTS
2026
Research grants (other domestic)
Developing and Evaluating AI-designed Binders to Regulate the Master Regulator of Cellular Homeostasis
2023
Research grants (international)
Membranes Matter: How Membrane Lipids Control Candida Albicans Cdr1 Structure and Function