A/Prof Laura Edgington-Mitchell
Associate Professor in Biochemistry & Pharmacology
Department of Biochemistry and Pharmacology
86 Scholarly works
7 Projects
HIGHLIGHTS
2026
Journal article
Probing the activity of cysteine cathepsins in inflammatory bowel diseases
DOI: 10.1038/s41598-025-32489-72026
Journal article
Advances in degradomics technologies to assess proteolytic cleavage events
DOI: 10.1016/j.chembiol.2026.01.0012026
Journal article
When Neutrophils Go Rogue: Dysregulated Inflammation in Airway Diseases and Implications for Therapy
DOI: 10.1021/acsptsci.5c006402026
Journal article
Intralysosomal pathogens differentially influence the proteolytic potential of their niche
DOI: 10.1128/iai.00270-252025
Research grants (ARC, NHMRC, MRFF)
Legumain at the Cutting Edge of Oral Cancer
2019
Research Grant
Proteases and Par2 Are Key Mediators of Cancer Pain
2018
Research Grant
Novel Chemical Tools to Study Cathepsin X Activation
RECENT SCHOLARLY WORKS
2025
Journal article
Employing complementary fractionation-based N-terminomics approaches enhances the identification of legumain cleavage events in naïve and inflamed colon tissue
DOI: 10.1002/pro.701862025
Journal article
Proteome and Secretome Profiling of the Melanoma-Induced Transition Toward Immune Incompetent Dendritic Cells Reveals Enhanced IDO1, Cathepsin, and Legumain Activity
DOI: 10.1016/j.mcpro.2025.1010482025
Journal article
N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins
DOI: 10.1002/pro.701442025
Journal article
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success
DOI: 10.1038/s41467-025-59283-32025
Journal article
Nuclear Roles for Canonically Lysosomal Proteases
DOI: 10.1080/10985549.2025.25191582025
Journal article
N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain
DOI: 10.1002/jcp.31466
RECENT PROJECTS
2026
Research grants (ARC, NHMRC, MRFF)
Pathogen-Mediated Manipulation of the Human Lysosome: A Target for Infection Control
2026
Research grants (other domestic)
2026 Research Impetus Grants