A/Prof Laura Edgington-Mitchell
Associate Professor in Biochemistry & Pharmacology
Department of Biochemistry and Pharmacology
89 Scholarly works
8 Projects
HIGHLIGHTS
2026
Journal article
Probing the activity of cysteine cathepsins in inflammatory bowel diseases
DOI: 10.1038/s41598-025-32489-72026
Research grants (other domestic)
ThermoFisher Orbitrap ASTRAL Zoom
2026
Journal article
PAC/SP3 On-Bead Carboxyl Derivatization Allows Combined C- and N-Terminomics
DOI: 10.1021/acs.analchem.6c019382026
Journal article
Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches
DOI: 10.1016/j.pharmr.2026.1001442026
Journal article
Advances in degradomics technologies to assess proteolytic cleavage events
DOI: 10.1016/j.chembiol.2026.01.0012025
Research grants (ARC, NHMRC, MRFF)
Legumain at the Cutting Edge of Oral Cancer
2018
Research Grant
Novel Chemical Tools to Study Cathepsin X Activation
RECENT SCHOLARLY WORKS
2026
Journal article
When Neutrophils Go Rogue: Dysregulated Inflammation in Airway Diseases and Implications for Therapy
DOI: 10.1021/acsptsci.5c006402026
Journal article
Intralysosomal pathogens differentially influence the proteolytic potential of their niche
DOI: 10.1128/iai.00270-252026
Journal article
Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients.
DOI: 10.1523/JNEUROSCI.0220-25.20252025
Journal article
Employing complementary fractionation-based N-terminomics approaches enhances the identification of legumain cleavage events in naïve and inflamed colon tissue
DOI: 10.1002/pro.701862025
Journal article
Proteome and Secretome Profiling of the Melanoma-Induced Transition Toward Immune Incompetent Dendritic Cells Reveals Enhanced IDO1, Cathepsin, and Legumain Activity
DOI: 10.1016/j.mcpro.2025.1010482025
Journal article
N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins
DOI: 10.1002/pro.70144
RECENT PROJECTS
2026
Research grants (ARC, NHMRC, MRFF)
Pathogen-Mediated Manipulation of the Human Lysosome: A Target for Infection Control
2026
Research grants (other domestic)
2026 Research Impetus Grants