Dr Larissa Doughty
Research Fellow
Department of Biochemistry and Pharmacology
27 Scholarly works
2 Projects
HIGHLIGHTS
2026
Journal article
ID #311 Targeting MYC-driven vulnerabilities in lethal childhood brain tumours using a first-in-class brain-penetrant MYC degrader
DOI: 10.1093/neuped/wuag026.0912025
Journal article
Correction to: Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer (Cell Death & Disease, (2024), 15, 4, (255), 10.1038/s41419-024-06631-8)
DOI: 10.1038/s41419-025-07631-y2025
Journal article
Abstract 6863: Development of MYCN/MYC inhibitors
DOI: 10.1158/1538-7445.am2025-68632024
Journal article
Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer
DOI: 10.1038/s41419-024-06631-82023
Journal article
Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant
DOI: 10.1038/s41467-023-42754-w2022
Research Grant
Overcoming Chemoresistance in Triple Negative Breast Cancer
2019
Research Contracts
Salary Contribution Larissa Doughty - St Vincents Institute of Med Res.
RECENT SCHOLARLY WORKS
2020
Thesis / Dissertation
Discovering inhibitors of cell surface receptor function as the basis for novel therapeutics to treat cancer
2019
Journal article
Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface
DOI: 10.1158/0008-5472.CAN-19-11122019
Journal article
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
DOI: 10.1016/j.isci.2019.07.0232015
Journal article
Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase
DOI: 10.1042/BJ201502702014
Journal article
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
DOI: 10.1038/srep04765