Dr Christopher Draper-Joyce
Honorary (Senior Fellow)
Florey Department of Neuroscience and Mental Health
17 Scholarly works
4 Projects
HIGHLIGHTS
2024
Journal article
Positive allosteric modulation of a GPCR ternary complex
DOI: 10.1126/sciadv.adp70402023
Research grants (ARC, NHMRC, MRFF)
Structural Biology and Protein Engineering to Accelerate Rational Development of Novel Antipsychotics
2021
Journal article
Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2: Defining the tethered agonist of RXFP1 and RXFP2
DOI: 10.1016/j.jmb.2021.1672172021
Journal article
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
DOI: 10.1038/s41586-021-03897-22021
Research grants (ARC, NHMRC, MRFF)
Relaxin Receptor Structural Determination to Aid Therapeutic Development
2021
Research Grant
Relaxin Receptor Structural Determination to Aid Therapeutic Development
2019
Journal article
Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D 2 Receptor
DOI: 10.1021/acs.jmedchem.8b00192
RECENT SCHOLARLY WORKS
2019
Journal article
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole
DOI: 10.1021/acschembio.9b003422019
Journal article
Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors
DOI: 10.1021/acsptsci.9b000542018
Journal article
The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions
DOI: 10.1038/s41598-018-19642-12018
Journal article
Rules of Engagement: GPCRs and G Proteins
DOI: 10.1021/acsptsci.8b000262018
Journal article
Dominant negative g proteins enhance formation and purification of agonist-gpcr-g protein complexes for structure determination
DOI: 10.1021/acsptsci.8b000172018
Journal article
Recent advances in the determination of G protein-coupled receptor structures
DOI: 10.1016/j.sbi.2018.03.002
RECENT PROJECTS
2020
Internal Research Grant
Structural Insights Into Activation, Dynamics and Bias of GPCRS