Dr Ngee Kiat Chua
Honorary Fellow
Department of Medical Biology (WEHI)
20 Scholarly works
0 Projects
HIGHLIGHTS
2026
Journal article
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
DOI: 10.1016/j.cell.2026.01.0292023
Journal article
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency
DOI: 10.15252/embj.20211104682022
Journal article
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
DOI: 10.1158/0008-5472.CAN-21-40122022
Journal article
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
DOI: 10.1038/s41467-022-29670-12021
Journal article
Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis
DOI: 10.1053/j.gastro.2020.09.0092021
Book Chapter
The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme
DOI: 10.1007/5584_2020_5832020
Journal article
Lipid sensing tips the balance for a key cholesterol synthesis enzyme
DOI: 10.1194/jlr.ILR120000801
RECENT SCHOLARLY WORKS
2020
Journal article
Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase
DOI: 10.1111/joim.130952020
Journal article
Squalene monooxygenase: a journey to the heart of cholesterol synthesis
DOI: 10.1016/j.plipres.2020.1010332020
Journal article
A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate
DOI: 10.1073/pnas.1915923117