Dr Katherine Davies
Honorary (Fellow)
Department of Medical Biology (WEHI)
10 Scholarly works
0 Projects
HIGHLIGHTS
2025
Journal article
Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity
DOI: 10.1042/BCJ202534312024
Journal article
Death at a funeral: Activation of the dead enzyme, MLKL, to kill cells by necroptosis
DOI: 10.1016/j.sbi.2024.1028912023
Journal article
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
DOI: 10.1038/s41467-023-42255-w2023
Journal article
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase
DOI: 10.1042/BCJ202300352023
Journal article
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors
DOI: 10.1021/acs.jmedchem.2c016212022
Journal article
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
DOI: 10.1038/s41418-022-00965-62021
Journal article
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
DOI: 10.1038/s41467-021-27032-x
RECENT SCHOLARLY WORKS
2020
Journal article
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
DOI: 10.1038/s41467-020-16823-32020
Journal article
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
DOI: 10.1073/pnas.19199601172018
Journal article
The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis
DOI: 10.1038/s41418-018-0061-3