LIMITING THE IMPACT OF INFLUENZA

Grant number: 1071916 | Funding period: 2015 - 2019

Completed

Abstract

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in communities worldwide. We have assembled a research team of seven groups who will determine the ways in which the effects of influenza can be mitigated through an understanding of the factors which lead to severe disease, and how these can be lessened by novel vaccination and treatment strategies.

Related publications (4)

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Establishment of memory CD8( ) T cells with live attenuated influenza virus across different vaccination doses

Zhongfang Wang, Lukasz Kedzierski, Simone Nuessing, Brendon Yew Loong Chua, Sergio M Quiones-Parra, Victor C Huber, David C Jackson, Paul G Thomas, Katherine Kedzierska

2016-12-01

FluMist has been used in children and adults for more than 10 years. As pre-existing CD8+ T cell memory pools can provide heterolo..

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Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

Liyen Loh, Zhongfang Wang, Sneha Sant, Marios Koutsakos, Sinthujan Jegaskanda, Alexandra J Corbett, Ligong Liu, David P Fairlie, Jane Crowe, Jamie Rossjohn, Jianqing Xu, Peter C Doherty, James McCluskey, Katherine Kedzierska

2016-09-06

Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit potent immunity to a broad range of bact..

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Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

Haiyin Liu, Reema Jain, Jing Guan, Vivian Vuong, Satoshi Ishido, Nicole L La Gruta, Daniel H Gray, Jose A Villadangos, Justine D Mintern

2016-08-22

Major histocompatibility complex class II (MHC II) expression is tightly regulated, being subjected to cell type-specific mechanis..

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Influenza NA and PB1 Gene Segments Interact during the Formation of Viral Progeny: Localization of the Binding Region within the PB1 Gene

Brad Gilbertson, Tian Zheng, Marie Gerber, Anne Printz-Schweigert, Chi Ong, Roland Marquet, Catherine Isel, Steven Rockman, Lorena Brown

2016-08-01

The influenza A virus genome comprises eight negative-sense viral RNAs (vRNAs) that form individual ribonucleoprotein (RNP) comple..