A COMBINED PET-FMRI STUDY OF FRONTOSTRIATAL DYSFUNCTION IN FIRST EPISODE PSYCHOSIS

Grant number: 1066779 | Funding period: 2014 - 2019

Completed

Abstract

Psychosis is a debilitating psychiatric syndrome affecting a person’s ability to understand reality. This project will map how disruptions of specific brain circuits give rise to psychosis, and how they relate to changes in the level of a specific brain chemical, dopamine, which is targeted by antipsychotic medications. This work has important implications for developing new, more targeted treatments.

Related publications (1)

Functional Connectivity of Corticostriatal Circuitry and Psychosis-like Experiences in the General Community

Kristina Sabaroedin, Jeggan Tiego, Linden Parkes, Francesco Sforazzini, Amy Finlay, Beth Johnson, Ari Pinar, Vanessa Cropley, Ben J Harrison, Andrew Zalesky, Christos Pantelis, Mark Bellgrove, Alex Fornito

2019-07-01

BACKGROUND: Psychotic symptoms are proposed to lie on a continuum, ranging from isolated psychosis-like experiences (PLEs) in nonc..