UNCOVERING THE PATHOGENESIS OF AGE-RELATED MACULAR DEGENERATION USING INDUCED PLURIPOTENT STEM CELLS
Grant number: 1059369 | Funding period: 2014 - 2016
Age-related macular degeneration (AMD) is a leading cause of blindness in the Western world. There is currently no treatment designed to prevent this loss of vision. We have identified patients with specific genetic risks associated with AMD. We will generate stem cells from these patients, allow the cells to be affected with AMD, then assess the differences and thus establish cellular features associated with each risk. This understanding may lead to uncovering new targets for novel treatments to prevent this common and devastating disease.
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Defined Medium Conditions for the Induction and Expansion of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium
Grace E Lidgerwood, Shiang Y Lim, Duncan E Crombie, Ray Ali, Katherine P Gill, Damian Hernandez, Josh Kie, Alison Conquest, Hayley S Waugh, Raymond CB Wong, Helena H Liang, Alex W Hewitt, Kathryn C Davidson, Alice Pebay