Understanding and Combating Bacterial Infections

Daptomycin selects for genetic and phenotypic adaptations leading to antibiotic tolerance in MRSA

AD Berti, N Shukla, AD Rottier, JS McCrone, HM Turner, IR Monk, SL Baines, BP Howden, RA Proctor, WE Rose

2018-08-01

Objectives: Daptomycin non-susceptibility in Staphylococcus aureus can emerge via the accumulation of single or multiple mutations..

Evolutionary origins of the emergent ST796 clone of vancomycin resistant Enterococcus faecium

AH Buultjens, MMC Lam, S Ballard, IR Monk, AA Mahony, EA Grabsch, ML Grayson, S Pang, GW Coombs, JO Robinson, T Seemann, PDR Johnson, BP Howden, TP Stinear

2017-01-01

From early 2012, a novel clone of vancomycin resistant Enterococcus faecium (assigned the multi locus sequence type ST796) was sim..

South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study

H Chung The, MA Rabaa, D Pham Thanh, N De Lappe, M Cormican, M Valcanis, BP Howden, S Wangchuk, L Bodhidatta, CJ Mason, T Nguyen Thi Nguyen, D Vu Thuy, CN Thompson, N Phu Huong Lan, P Voong Vinh, T Ha Thanh, P Turner, P Sar, G Thwaites, NR Thomson

2016-08-01

Background: Antimicrobial resistance is a major issue in the Shigellae, particularly as a specific multidrug-resistant (MDR) linea..

Prospective whole-genome sequencing enhances national surveillance of listeria monocytogenes

JC Kwong, K Mercoulia, T Tomita, M Easton, HY Li, DM Bulach, TP Stinear, T Seemann, BP Howden

2016-02-01

Whole-genome sequencing (WGS) has emerged as a powerful tool for comparing bacterial isolates in outbreak detection and investigat..

Combination of Vancomycin and β-Lactam Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: A Pilot Multicenter Randomized Controlled Trial

JS Davis, A Sud, MVN O'Sullivan, JO Robinson, PE Ferguson, H Foo, SJ Van Hal, AP Ralph, BP Howden, PM Binks, A Kirby, SYC Tong, S Majumdar, R Baird, C Gordon, C Jeremiah, G Leung, A Brischetto, A Crowe, F Dakh

2016-01-15

Background. In vitro laboratory and animal studies demonstrate a synergistic role for the combination of vancomycin and antistaphy..

CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: Study protocol for a randomised controlled trial

SYC Tong, J Nelson, DL Paterson, VG Fowler, BP Howden, AC Cheng, M Chatfield, J Lipman, S Van Hal, M O'Sullivan, JO Robinson, D Yahav, D Lye, JS Davis

2016-01-01

Background: Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mort..

Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: A cross-sectional study

KS Baker, TJ Dallman, PM Ashton, M Day, G Hughes, PD Crook, VL Gilbart, S Zittermann, VG Allen, BP Howden, T Tomita, M Valcanis, SR Harris, TR Connor, V Sintchenko, P Howard, JD Brown, NK Petty, M Gouali, DP Thanh

2015-08-01

Background: Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel ..

Molecular characterization and antimicrobial susceptibilities of Clostridium difficile clinical isolates from Victoria, Australia

KE Mackin, B Elliott, D Kotsanas, BP Howden, GP Carter, TM Korman, TV Riley, JI Rood, GA Jenkin, D Lyras

2015-08-01

Some Australian strain types of Clostridium difficile appear unique, highlighting the global diversity of this bacterium. We exami..

Vancomycin in the treatment of methicillin-resistant Staphylococcus aureus - A clinician's guide to the science informing current practice

JY Lee, BP Howden

2015-07-01

Clinicians treating an infection assess a patient in terms of disease manifestation, causative organism and available antibiotic o..

Complete bypass of restriction systems for major staphylococcus aureus lineages

IR Monk, JJ Tree, BP Howden, TP Stinear, TJ Foster

2015-05-12

Staphylococcus aureus is a prominent global nosocomial and community-acquired bacterial pathogen. A strong restriction barrier pre..

Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics

AD Berti, SL Baines, BP Howden, G Sakoulas, V Nizet, RA Proctor, WE Rose

2015-05-01

Daptomycin is increasingly used in combination with other antibiotics to enhance antimicrobial efficacy and/or to mitigate the eme..

Whole genome sequencing in clinical and public health microbiology

JC Kwong, N Mccallum, V Sintchenko, BP Howden

2015-04-01

Genomics and whole genome sequencing (WGS) have the capacity to greatly enhance knowledge and understanding of infectious diseases..

Convergent adaptation in the dominant global hospital clone ST239 of methicillin-resistant Staphylococcus aureus

SL Baines, KE Holt, MB Schultz, T Seemann, BO Howden, SO Jensen, SJ van Hal, GW Coombs, N Firth, DR Powell, TP Stinear, BP Howden

2015-01-01

Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HAMRSA) are a ma..

Large tandem chromosome expansions facilitate niche adaptation during persistent infection with drug-resistant staphylococcus aureus

W Gao, IR Monk, NJ Tobias, SL Gladman, T Seemann, TP Stinear, BP Howden

2015-01-01

We used genomics to study the evolution of meticillin-resistant Staphylococcus aureus (MRSA) during a complex, protracted clinical..

Adaptive change inferred from genomic population analysis of the ST93 epidemic clone of community-associated methicillin-resistant Staphylococcus aureus

TP Stinear, KE Holt, K Chua, J Stepnell, KL Tuck, G Coombs, PF Harrison, T Seemann, BP Howden

2014-02-01

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as a major public health problem around the..

Genomic insights to control the emergence of vancomycin-resistant enterococci

BP Howden, KE Holt, MMC Lam, T Seemann, S Ballard, GW Coombs, SYC Tong, M Lindsay Grayson, PDR Johnson, TP Stinear

2013-08-13

Nosocomial outbreaks of vancomycin-resistant Enterococcus faecium (VREfm) are thought to occur by transmission of VREfm between pa..