CELL INTERACTIONS PRODUCING HIV LATENCY
Grant number: 1041795 | Funding period: 2014 - 2015
Current anti-HIV therapies can't cure HIV because HIV remains silent(latent) in long-lived cells. The HIV life cycle and virus production is linked to activation of the host cell, which is regulated by dendritic cells. This grant will explore how the factors controlling T cell activation and proliferation control virus expression and latency. By understanding how latent infection is established and maintained, these studies will potentially identify new ways to eliminate HIV infection.
Related publications (1)
Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4( ) T Cells
Vanessa A Evans, Nitasha Kumar, Ali Filali, Francesco A Procopio, Oleg Yegorov, Jean-Philippe Goulet, Suha Saleh, Elias K Haddad, Candida da Fonseca Pereira, Paula C Ellenberg, Rafick-Pierre Sekaly, Paul U Cameron, Sharon R Lewin
Latently infected resting CD4(+) T cells are a major barrier to HIV cure. Understanding how latency is established, maintained and..