ARC CENTRE OF EXCELLENCE IN CONVERGENT BIO–NANO SCIENCE AND TECHNOLOGY

In Situ Characterization of Protein Corona Formation on Silica Microparticles Using Confocal Laser Scanning Microscopy Combined with Microfluidics

Alessia CG Weiss, Kilian Krueger, Quinn A Besford, Mathias Schlenk, Kristian Kempe, Stephan Foerster, Frank Caruso

2019-01-16

In biological fluids, proteins bind to particles, forming so-called protein coronas. Such adsorbed protein layers significantly in..

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

Marcin Wojnilowicz, Agata Glab, Alessandro Bertucci, Frank Caruso, Francesca Cavalieri

2019-01-01

The intracellular delivery of nucleic acids and proteins remains a key challenge in the development of biological therapeutics. In..

Supramolecular Metal-Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients

Md Arifur Rahim, Yuuki Hata, Mattias Bjornmalm, Yi Ju, Frank Caruso

2018-06-27

The use of supramolecular gel media for the crystallization of active pharmaceutical ingredients (APIs) is of interest for control..

The complexities and caveats of lineage tracing in the mammary gland

Anne C Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J Lindeman, Jane E Visvader

2016-11-25

Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this tech..

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds

2016-04-01

Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas gingivalis, Treponema denticola and Tan..

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

2015-01-01

INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..