ARC CENTRE OF EXCELLENCE IN CONVERGENT BIO–NANO SCIENCE AND TECHNOLOGY
Grant number: CE140100036 | Funding period: 2014 - 2021
Related publications (57)
Ordered Mesoporous Metal-Phenolic Network Particles.
Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso
Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..
Probing Transcription Factor Binding Activity and Downstream Gene Silencing in Living Cells with a DNA Nanoswitch
A Bertucci, J Guo, N Oppmann, A Glab, F Ricci, F Caruso, F Cavalieri
Transcription factor DNA binding activity is of pivotal importance in living systems because of its primary involvement in the reg..
Precise control of drug loading and release of an NSAID-polymer conjugate for long term osteoarthritis intra-articular drug delivery
Adrian Sulistio, Felisa Reyes-Ortega, Asha M D'Souza, Sarah MY Ng, David Valade, John F Quinn, Andrew C Donohue, Friederike Mansfeld, Anton Blencowe, Greg Qiao, Richard Prankerd, Stephen Quirk, Michael R Whittaker, Thomas P Davis, Russell J Tait
A facile synthesis method of polymer diclofenac conjugates (PDCs) based on biocompatible polyurethane chemistry that provides a hi..
An Enzyme-Coated Metal-Organic Framework Shell for Synthetically Adaptive Cell Survival
Kang Liang, Joseph J Richardson, Christian J Doonan, Xavier Mulet, Yi Ju, Jiwei Cui, Frank Caruso, Paolo Falcaro
A bioactive synthetic porous shell was engineered to enable cells to survive in an oligotrophic environment. Eukaryotic cells (yea..
Tuning the Properties of Polymer Capsules for Cellular Interactions
Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar HH Wong, Jenny Tran, Greg G Qiao, Frank Caruso
Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, ..
A Transcriptional Program for Detecting TGF beta-Induced EMT in Cancer
Momeneh Foroutan, Joseph Cursons, Soroor Hediyeh-Zadeh, Erik W Thompson, Melissa J Davis
Most cancer deaths are due to metastasis, and epithelial-to-mesenchymal transition (EMT) plays a central role in driving cancer ce..
Interactions between circulating nanoengineered polymer particles and extracellular matrix components in vitro
Julia A Braunger, Mattias Bjornmalm, Nathan A Isles, Jiwei Cui, Timothy MA Henderson, Andrea J O'Connor, Frank Caruso
The extracellular matrix (ECM) that surrounds cells in vivo represents a biological barrier for nanomaterials in biomedicine. Here..
Biofunctional metal-phenolic films from dietary flavonoids
Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso
We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules,..
Patterned Poly(dopamine) Films for Enhanced Cell Adhesion
Xi Chen, Christina Cortez-Jugo, Gwan H Choi, Mattias Bjornmalm, Yunlu Dai, Pil J Yoo, Frank Caruso
Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In ..
Modular assembly of superstructures from polyphenol-functionalized building blocks
Junling Guo, Blaise L Tardy, Andrew J Christofferson, Yunlu Dai, Joseph J Richardson, Wei Zhu, Ming Hu, Yi Ju, Jiwei Cui, Raymond R Dagastine, Irene Yarovsky, Frank Caruso
The organized assembly of particles into superstructures is typically governed by specific molecular interactions or external dire..
A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions
Jiwei Cui, Matthew Faria, Mattias Bjornmalm, Yi Ju, Tomoya Suma, Sylvia T Gunawan, Joseph J Richardson, Hamed Heidar, Sara Bals, Edmund J Crampin, Frank Caruso
In vitro experiments provide a solid basis for understanding the interactions between particles and biological systems. An importa..
Systems analysis identifies miR-29b regulation of invasiveness in melanoma
Miles C Andrews, Joseph Cursons, Daniel G Hurley, Matthew Anaka, Jonathan S Cebon, Andreas Behren, Edmund J Crampin
BACKGROUND: In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processe..
Synthesis of Chemically Asymmetric Silica Nanobottles and Their Application for Cargo Loading and as Nanoreactors and Nanomotors
Deliang Yi, Qian Zhang, Yinghua Liu, Jiaying Song, Yi Tang, Frank Caruso, Yajun Wang
We report the synthesis of chemically asymmetric silica nanobottles (NBs) with a hydrophobic exterior surface (capped with 3-chlor..
Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses
Katelyn T Gause, Yan Yan, Neil M O'Brien-Simpson, Jiwei Cui, Jason C Lenzo, Eric C Reynolds, Frank Caruso
Vaccine adjuvants that can induce robust protective immunity are highly sought after for the development of safer and more effecti..
Dynamic Flow Impacts Cell-Particle Interactions: Sedimentation and Particle Shape Effects
Mattias Bjornmalm, Matthew Faria, Xi Chen, Jiwei Cui, Frank Caruso
The interaction of engineered particles with biological systems determines their performance in biomedical applications. Although ..
Metal-Phenolic Supramolecular Gelation
Md Arifur Rahim, Mattias Bjornmalm, Tomoya Suma, Matthew Faria, Yi Ju, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Anthony D Stickland, Frank Caruso
Materials assembled by coordination interactions between naturally abundant polyphenols and metals are of interest for a wide rang..
Toward Community Standards and Software for Whole-Cell Modeling
Dagmar Waltemath, Jonathan R Karr, Frank T Bergmann, Vijayalakshmi Chelliah, Michael Hucka, Marcus Krantz, Wolfram Liebermeister, Pedro Mendes, Chris J Myers, Pinar Pir, Begum Alaybeyoglu, Naveen K Aranganathan, Kambiz Baghalian, Arne T Bittig, Paulo E Pinto Burke, Matteo Cantarelli, Yin Hoon Chew, Rafael S Costa, Joseph Cursons, Tobias Czauderna
OBJECTIVE: Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantia..
Metal-Organic Framework Coatings as Cytoprotective Exoskeletons for Living Cells
Kang Liang, Joseph J Richardson, Jiwei Cui, Frank Caruso, Christian J Doonan, Paolo Falcaro
The biomimetic mineralization of metal-organic framework (MOF) material on living cells is reported. ZIF-8 can be crystallized on ..
Polymer Capsules for Plaque-Targeted In Vivo Delivery
Joseph J Richardson, Mei Y Choy, Junling Guo, Kang Liang, Karen Alt, Yuan Ping, Jiwei Cui, Lok S Law, Christoph E Hagemeyer, Frank Caruso
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of ..
In situ layer-by-layer assembled carbonic anhydrase-coated hollow fiber membrane contactor for rapid CO2 absorption
Joel KJ Yong, Geoffrey W Stevens, Frank Caruso, Sandra E Kentish
The use of potassium carbonate as a solvent for the absorption of carbon dioxide is constrained by slow absorption kinetics, which..
Improving Targeting of Metal-Phenolic Capsules by the Presence of Protein Coronas
Yi Ju, Qiong Dai, Jiwei Cui, Yunlu Dai, Tomoya Suma, Joseph J Richardson, Frank Caruso
Particles adsorb proteins when they enter a physiological environment; this results in a surface coating termed a "protein corona"..
Immobilized Particle Imaging for Quantification of Nano- and Microparticles
Jiwei Cui, Benjamin Hibbs, Sylvia T Gunawan, Julia A Braunger, Xi Chen, Joseph J Richardson, Eric Hanssen, Frank Caruso
The quantification of nano- and microparticles is critical for diverse applications relying on the exact knowledge of the particle..
Analysing intracellular deformation of polymer capsules using structured illumination microscopy
Xi Chen, Jiwei Cui, Huanli Sun, Markus Mullner, Yan Yan, Ka Fung Noi, Yuan Ping, Frank Caruso
Understanding the behaviour of therapeutic carriers is important in elucidating their mechanism of action and how they are process..
Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes
Blaise L Tardy, Shereen Tan, Henk H Dam, Hirotaka Ejima, Anton Blencowe, Greg G Qiao, Frank Caruso
Supramolecular polymers with monomers bound together by secondary interactions, such as polyrotaxanes (PRXs), consisting of alpha ..
Probing cell internalisation mechanics with polymer capsules
Xi Chen, Jiwei Cui, Yuan Ping, Tomoya Suma, Francesca Cavalieri, Quinn A Besford, George Chen, Julia A Braunger, Frank Caruso
We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(me..
Biomimetic Replication of Microscopic Metal-Organic Framework Patterns Using Printed Protein Patterns
Kang Liang, Carlos Carbonell, Mark J Styles, Raffaele Ricco, Jiwei Cui, Joseph J Richardson, Daniel Maspoch, Frank Caruso, Paolo Falcaro
It is demonstrated that metal-organic frameworks (MOFs) can be replicated in a biomimetic fashion from protein patterns. Bendable,..
Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model
Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso
Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular proces..
Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas
Qiong Dai, Yan Yan, Junling Guo, Mattias Bjoernmalm, Jiwei Cui, Huanli Sun, Frank Caruso
Protein coronas formed on engineered particles can alter their targeting ability as they enter biological environments. Here, we e..
Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets
Sylvia T Gunawan, Kristian Kempe, Thomas Bonnard, Jiwei Cui, Karen Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina K Such, Karlheinz Peter, Christoph E Hagemeyer, Frank Caruso
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the su..
Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols
Junling Guo, Huanli Sun, Karen Alt, Blaise L Tardy, Joseph J Richardson, Tomoya Suma, Hirotaka Ejima, Jiwei Cui, Christoph E Hagemeyer, Frank Caruso
Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials..
Surface-Confined Amorphous Films from Metal-Coordinated Simple Phenolic Ligands
Md Arifur Rahim, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Yi Ju, Martin P van Koeverden, Tomoya Suma, Julia A Braunger, Michael G Leeming, Brendan F Abrahams, Frank Caruso
Coordination chemistry of natural polyphenols and transition metals allows rapid self-assembly of conformal coatings on diverse su..
Surface Engineering of Polypropylene Membranes with Carbonic Anhydrase-Loaded Mesoporous Silica Nanoparticles for Improved Carbon Dioxide Hydration
Joel KJ Yong, Jiwei Cui, Kwun Lun Cho, Geoff W Stevens, Frank Caruso, Sandra E Kentish
Carbonic anhydrase (CA) is a native enzyme that facilitates the hydration of carbon dioxide into bicarbonate ions. This study repo..
Chlorine Resistant Glutaraldehyde Crosslinked Polyelectrolyte Multilayer Membranes for Desalination
Kwun Lun Cho, Anita J Hill, Frank Caruso, Sandra E Kentish
Crosslinked polyelectrolyte multilayer membranes are synthesized with salt rejection values approaching those of commercial desali..
pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery
Yuan Ping, Junling Guo, Hirotaka Ejima, Xi Chen, Joseph J Richardson, Huanli Sun, Frank Caruso
A new class of pH-responsive capsules based on metal-phenolic networks (MPNs) for anticancer drug loading, delivery and release is..
Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks
Yi Ju, Jiwei Cui, Markus Muellner, Tomoya Suma, Ming Hu, Frank Caruso
Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strat..
Monoclonal Antibody-Functionalized Multilayered Particles: Targeting Cancer Cells in the Presence of Protein Coronas
Qiong Dai, Yan Yan, Ching-Seng Ang, Kristian Kempe, Marloes MJ Kamphuis, Sarah J Dodds, Frank Caruso
Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form a layer called a "corona"..
Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States
Katelyn T Gause, Yan Yan, Jiwei Cui, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Frank Caruso
The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a wh..
Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties In Vivo
Markus Muellner, Sarah J Dodds, Nguyen Tri-Hung, Danielle Senyschyn, Christopher JH Porter, Ben J Boyd, Frank Caruso
Studies of spherical nanoengineered drug delivery systems have suggested that particle size and mechanical properties are key dete..
The "Sweet" Side of the Protein Corona: Effects of Glycosylation on Nanoparticle-Cell Interactions
Sha Wan, Philip M Kelly, Eugene Mahon, Henning Stockmann, Pauline M Rudd, Frank Caruso, Kenneth A Dawson, Yan Yan, Marco P Monopoli
The significance of a protein corona on nanoparticles in modulating particle properties and their biological interactions has been..
Versatile Loading of Diverse Cargo into Functional Polymer Capsules
Joseph J Richardson, James W Maina, Hirotaka Ejima, Ming Hu, Junling Guo, Mei Y Choy, Sylvia T Gunawan, Lien Lybaert, Christoph E Hagemeyer, Bruno G De Geest, Frank Caruso
Polymer microcapsules are of particular interest for applications including self-healing coatings, catalysis, bioreactions, sensin..
Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines
J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson
INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..
Unravelling "off-target" effects of redox-active polymers and polymer multilayered capsules in prostate cancer cells
Giovanni L Beretta, Marco Folini, Francesca Cavalieri, Yan Yan, Enrico Fresch, Subramanian Kaliappan, Christoph Hasenhoerl, Joseph J Richardson, Stella Tinelli, Andreas Fery, Frank Caruso, Nadia Zaffaroni
Redox-active polymers and carriers are oxidizing nanoagents that can potentially trigger intracellular off-target effects. In the ..