ARC CENTRE OF EXCELLENCE IN CONVERGENT BIO–NANO SCIENCE AND TECHNOLOGY

Predicting population extinction in lattice-based birth-death-movement models

Stuart T Johnston, Matthew J Simpson, Edmund J Crampin

2020-06-24

The question of whether a population will persist or go extinct is of key interest throughout ecology and biology. Various mathema..

Ordered Mesoporous Metal-Phenolic Network Particles.

Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso

2020-01-08

Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..

Probing Transcription Factor Binding Activity and Downstream Gene Silencing in Living Cells with a DNA Nanoswitch

A Bertucci, J Guo, N Oppmann, A Glab, F Ricci, F Caruso, F Cavalieri

2018-01-28

Transcription factor DNA binding activity is of pivotal importance in living systems because of its primary involvement in the reg..

Bridging Bio-Nano Science and Cancer Nanomedicine

Mattias Bjornmalm, Kristofer J Thurecht, Michael Michael, Andrew M Scott, Frank Caruso

2017-10-01

The interface of bio-nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core ..

Precise control of drug loading and release of an NSAID-polymer conjugate for long term osteoarthritis intra-articular drug delivery

Adrian Sulistio, Felisa Reyes-Ortega, Asha M D'Souza, Sarah MY Ng, David Valade, John F Quinn, Andrew C Donohue, Friederike Mansfeld, Anton Blencowe, Greg Qiao, Richard Prankerd, Stephen Quirk, Michael R Whittaker, Thomas P Davis, Russell J Tait

2017-08-21

A facile synthesis method of polymer diclofenac conjugates (PDCs) based on biocompatible polyurethane chemistry that provides a hi..

An Enzyme-Coated Metal-Organic Framework Shell for Synthetically Adaptive Cell Survival

Kang Liang, Joseph J Richardson, Christian J Doonan, Xavier Mulet, Yi Ju, Jiwei Cui, Frank Caruso, Paolo Falcaro

2017-07-10

A bioactive synthetic porous shell was engineered to enable cells to survive in an oligotrophic environment. Eukaryotic cells (yea..

The resilience of carbonic anhydrase enzyme for membrane-based carbon capture applications

Joel KJ Yong, Geoffrey W Stevens, Frank Caruso, Sandra E Kentish

2017-07-01

A microbial carbonic anhydrase was immobilized onto the surface of hollow fiber membranes to enhance the absorption rate of carbon..

Tuning the Properties of Polymer Capsules for Cellular Interactions

Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar HH Wong, Jenny Tran, Greg G Qiao, Frank Caruso

2017-07-01

Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, ..

Energy-based analysis of biomolecular pathways

Peter J Gawthrop, Edmund J Crampin

2017-06-01

Decomposition of biomolecular reaction networks into pathways is a powerful approach to the analysis of metabolic and signalling n..

A Transcriptional Program for Detecting TGF beta-Induced EMT in Cancer

Momeneh Foroutan, Joseph Cursons, Soroor Hediyeh-Zadeh, Erik W Thompson, Melissa J Davis

2017-05-01

Most cancer deaths are due to metastasis, and epithelial-to-mesenchymal transition (EMT) plays a central role in driving cancer ce..

Interactions between circulating nanoengineered polymer particles and extracellular matrix components in vitro

Julia A Braunger, Mattias Bjornmalm, Nathan A Isles, Jiwei Cui, Timothy MA Henderson, Andrea J O'Connor, Frank Caruso

2017-02-01

The extracellular matrix (ECM) that surrounds cells in vivo represents a biological barrier for nanomaterials in biomedicine. Here..

Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

Hirotaka Ejima, Joseph J Richardson, Frank Caruso

2017-02-01

Surface modification is crucial for conferring novel functionalities to objects and interfaces. However, simple yet versatile stra..

Biofunctional metal-phenolic films from dietary flavonoids

Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso

2017-01-18

We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules,..

Patterned Poly(dopamine) Films for Enhanced Cell Adhesion

Xi Chen, Christina Cortez-Jugo, Gwan H Choi, Mattias Bjornmalm, Yunlu Dai, Pil J Yoo, Frank Caruso

2017-01-01

Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In ..

Innovation in Layer-by-Layer Assembly

Joseph J Richardson, Jiwei Cui, Mattias Bjornmalm, Julia A Braunger, Hirotaka Ejima, Frank Caruso

2016-12-14

Methods for depositing thin films are important in generating functional materials for diverse applications in a wide variety of f..

Modular assembly of superstructures from polyphenol-functionalized building blocks

Junling Guo, Blaise L Tardy, Andrew J Christofferson, Yunlu Dai, Joseph J Richardson, Wei Zhu, Ming Hu, Yi Ju, Jiwei Cui, Raymond R Dagastine, Irene Yarovsky, Frank Caruso

2016-12-01

The organized assembly of particles into superstructures is typically governed by specific molecular interactions or external dire..

A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions

Jiwei Cui, Matthew Faria, Mattias Bjornmalm, Yi Ju, Tomoya Suma, Sylvia T Gunawan, Joseph J Richardson, Hamed Heidar, Sara Bals, Edmund J Crampin, Frank Caruso

2016-11-29

In vitro experiments provide a solid basis for understanding the interactions between particles and biological systems. An importa..

The complexities and caveats of lineage tracing in the mammary gland

Anne C Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J Lindeman, Jane E Visvader

2016-11-25

Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this tech..

Systems analysis identifies miR-29b regulation of invasiveness in melanoma

Miles C Andrews, Joseph Cursons, Daniel G Hurley, Matthew Anaka, Jonathan S Cebon, Andreas Behren, Edmund J Crampin

2016-11-16

BACKGROUND: In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processe..

Synthesis of Chemically Asymmetric Silica Nanobottles and Their Application for Cargo Loading and as Nanoreactors and Nanomotors

Deliang Yi, Qian Zhang, Yinghua Liu, Jiaying Song, Yi Tang, Frank Caruso, Yajun Wang

2016-11-14

We report the synthesis of chemically asymmetric silica nanobottles (NBs) with a hydrophobic exterior surface (capped with 3-chlor..

Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses

Katelyn T Gause, Yan Yan, Neil M O'Brien-Simpson, Jiwei Cui, Jason C Lenzo, Eric C Reynolds, Frank Caruso

2016-11-02

Vaccine adjuvants that can induce robust protective immunity are highly sought after for the development of safer and more effecti..

Dynamic Flow Impacts Cell-Particle Interactions: Sedimentation and Particle Shape Effects

Mattias Bjornmalm, Matthew Faria, Xi Chen, Jiwei Cui, Frank Caruso

2016-10-25

The interaction of engineered particles with biological systems determines their performance in biomedical applications. Although ..

Metal-Phenolic Supramolecular Gelation

Md Arifur Rahim, Mattias Bjornmalm, Tomoya Suma, Matthew Faria, Yi Ju, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Anthony D Stickland, Frank Caruso

2016-10-24

Materials assembled by coordination interactions between naturally abundant polyphenols and metals are of interest for a wide rang..

Increasing the Impact of Materials in and beyond Bio-Nano Science

Mattias Bjornmalm, Matthew Faria, Frank Caruso

2016-10-19

This is an exciting time for the field of bio-nano science: enormous progress has been made in recent years, especially in academi..

Modular bond-graph modelling and analysis of biomolecular systems

Peter J Gawthrop, Edmund J Crampin

2016-10-01

Bond graphs can be used to build thermodynamically-compliant hierarchical models of biomolecular systems. As bond graphs have been..

Toward Community Standards and Software for Whole-Cell Modeling

Dagmar Waltemath, Jonathan R Karr, Frank T Bergmann, Vijayalakshmi Chelliah, Michael Hucka, Marcus Krantz, Wolfram Liebermeister, Pedro Mendes, Chris J Myers, Pinar Pir, Begum Alaybeyoglu, Naveen K Aranganathan, Kambiz Baghalian, Arne T Bittig, Paulo E Pinto Burke, Matteo Cantarelli, Yin Hoon Chew, Rafael S Costa, Joseph Cursons, Tobias Czauderna

2016-10-01

OBJECTIVE: Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantia..

Metal-Organic Framework Coatings as Cytoprotective Exoskeletons for Living Cells

Kang Liang, Joseph J Richardson, Jiwei Cui, Frank Caruso, Christian J Doonan, Paolo Falcaro

2016-09-28

The biomimetic mineralization of metal-organic framework (MOF) material on living cells is reported. ZIF-8 can be crystallized on ..

Polymer Capsules for Plaque-Targeted In Vivo Delivery

Joseph J Richardson, Mei Y Choy, Junling Guo, Kang Liang, Karen Alt, Yuan Ping, Jiwei Cui, Lok S Law, Christoph E Hagemeyer, Frank Caruso

2016-09-21

Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of ..

In situ layer-by-layer assembled carbonic anhydrase-coated hollow fiber membrane contactor for rapid CO2 absorption

Joel KJ Yong, Geoffrey W Stevens, Frank Caruso, Sandra E Kentish

2016-09-15

The use of potassium carbonate as a solvent for the absorption of carbon dioxide is constrained by slow absorption kinetics, which..

Improving Targeting of Metal-Phenolic Capsules by the Presence of Protein Coronas

Yi Ju, Qiong Dai, Jiwei Cui, Yunlu Dai, Tomoya Suma, Joseph J Richardson, Frank Caruso

2016-09-07

Particles adsorb proteins when they enter a physiological environment; this results in a surface coating termed a "protein corona"..

Modelling modal gating of ion channels with hierarchical Markov models

Ivo Siekmann, Mark Fackrell, Edmund J Crampin, Peter Taylor

2016-08-01

Many ion channels spontaneously switch between different levels of activity. Although this behaviour known as modal gating has bee..

Immobilized Particle Imaging for Quantification of Nano- and Microparticles

Jiwei Cui, Benjamin Hibbs, Sylvia T Gunawan, Julia A Braunger, Xi Chen, Joseph J Richardson, Eric Hanssen, Frank Caruso

2016-04-12

The quantification of nano- and microparticles is critical for diverse applications relying on the exact knowledge of the particle..

Analysing intracellular deformation of polymer capsules using structured illumination microscopy

Xi Chen, Jiwei Cui, Huanli Sun, Markus Mullner, Yan Yan, Ka Fung Noi, Yuan Ping, Frank Caruso

2016-01-01

Understanding the behaviour of therapeutic carriers is important in elucidating their mechanism of action and how they are process..

Nanoparticles assembled via pH-responsive reversible segregation of cyclodextrins in polyrotaxanes

Blaise L Tardy, Shereen Tan, Henk H Dam, Hirotaka Ejima, Anton Blencowe, Greg G Qiao, Frank Caruso

2016-01-01

Supramolecular polymers with monomers bound together by secondary interactions, such as polyrotaxanes (PRXs), consisting of alpha ..

Probing cell internalisation mechanics with polymer capsules

Xi Chen, Jiwei Cui, Yuan Ping, Tomoya Suma, Francesca Cavalieri, Quinn A Besford, George Chen, Julia A Braunger, Frank Caruso

2016-01-01

We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(me..

Hierarchical bond graph modelling of biochemical networks

PG Gawthrop, J CURSONS, EJ Crampin

2015-12-08

The bond graph approach to modelling biochemical networks is extended to allow hierarchical construction of complex models from si..

Biomimetic Replication of Microscopic Metal-Organic Framework Patterns Using Printed Protein Patterns

Kang Liang, Carlos Carbonell, Mark J Styles, Raffaele Ricco, Jiwei Cui, Joseph J Richardson, Daniel Maspoch, Frank Caruso, Paolo Falcaro

2015-12-02

It is demonstrated that metal-organic frameworks (MOFs) can be replicated in a biomimetic fashion from protein patterns. Bendable,..

Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model

Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso

2015-11-01

Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular proces..

Targeting Ability of Affibody-Functionalized Particles Is Enhanced by Albumin but Inhibited by Serum Coronas

Qiong Dai, Yan Yan, Junling Guo, Mattias Bjoernmalm, Jiwei Cui, Huanli Sun, Frank Caruso

2015-11-01

Protein coronas formed on engineered particles can alter their targeting ability as they enter biological environments. Here, we e..

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Sylvia T Gunawan, Kristian Kempe, Thomas Bonnard, Jiwei Cui, Karen Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina K Such, Karlheinz Peter, Christoph E Hagemeyer, Frank Caruso

2015-09-16

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the su..

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols

Junling Guo, Huanli Sun, Karen Alt, Blaise L Tardy, Joseph J Richardson, Tomoya Suma, Hirotaka Ejima, Jiwei Cui, Christoph E Hagemeyer, Frank Caruso

2015-08-26

Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials..

Surface-Confined Amorphous Films from Metal-Coordinated Simple Phenolic Ligands

Md Arifur Rahim, Kristian Kempe, Markus Muellner, Hirotaka Ejima, Yi Ju, Martin P van Koeverden, Tomoya Suma, Julia A Braunger, Michael G Leeming, Brendan F Abrahams, Frank Caruso

2015-08-25

Coordination chemistry of natural polyphenols and transition metals allows rapid self-assembly of conformal coatings on diverse su..

Capsosomes as Long-Term Delivery Vehicles for Protein Therapeutics.

JW Maina, JJ Richardson, R Chandrawati, K Kempe, MP van Koeverden, F Caruso

2015-07-09

We report the preparation of polymer capsules containing liposomal subcompartments, termed capsosomes, and their ability for the s..

Surface Engineering of Polypropylene Membranes with Carbonic Anhydrase-Loaded Mesoporous Silica Nanoparticles for Improved Carbon Dioxide Hydration

Joel KJ Yong, Jiwei Cui, Kwun Lun Cho, Geoff W Stevens, Frank Caruso, Sandra E Kentish

2015-06-09

Carbonic anhydrase (CA) is a native enzyme that facilitates the hydration of carbon dioxide into bicarbonate ions. This study repo..

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

2015-05-15

INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..

Chlorine Resistant Glutaraldehyde Crosslinked Polyelectrolyte Multilayer Membranes for Desalination

Kwun Lun Cho, Anita J Hill, Frank Caruso, Sandra E Kentish

2015-05-06

Crosslinked polyelectrolyte multilayer membranes are synthesized with salt rejection values approaching those of commercial desali..

pH-Responsive Capsules Engineered from Metal-Phenolic Networks for Anticancer Drug Delivery

Yuan Ping, Junling Guo, Hirotaka Ejima, Xi Chen, Joseph J Richardson, Huanli Sun, Frank Caruso

2015-05-06

A new class of pH-responsive capsules based on metal-phenolic networks (MPNs) for anticancer drug loading, delivery and release is..

Technology-driven layer-by-layer assembly of nanofilms

Joseph J Richardson, Mattias Bjoernmalm, Frank Caruso

2015-04-24

Multilayer thin films have garnered intense scientific interest due to their potential application in diverse fields such as catal..

Interfacing Materials Science and Biology for Drug Carrier Design

Georgina K Such, Yan Yan, Angus PR Johnston, Sylvia T Gunawan, Frank Caruso

2015-04-08

Over the last ten years, there has been considerable research interest in the development of polymeric carriers for biomedicine. S..

Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Yi Ju, Jiwei Cui, Markus Muellner, Tomoya Suma, Ming Hu, Frank Caruso

2015-03-01

Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strat..

Monoclonal Antibody-Functionalized Multilayered Particles: Targeting Cancer Cells in the Presence of Protein Coronas

Qiong Dai, Yan Yan, Ching-Seng Ang, Kristian Kempe, Marloes MJ Kamphuis, Sarah J Dodds, Frank Caruso

2015-03-01

Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form a layer called a "corona"..

Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States

Katelyn T Gause, Yan Yan, Jiwei Cui, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Frank Caruso

2015-03-01

The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a wh..

Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties In Vivo

Markus Muellner, Sarah J Dodds, Nguyen Tri-Hung, Danielle Senyschyn, Christopher JH Porter, Ben J Boyd, Frank Caruso

2015-02-01

Studies of spherical nanoengineered drug delivery systems have suggested that particle size and mechanical properties are key dete..

The "Sweet" Side of the Protein Corona: Effects of Glycosylation on Nanoparticle-Cell Interactions

Sha Wan, Philip M Kelly, Eugene Mahon, Henning Stockmann, Pauline M Rudd, Frank Caruso, Kenneth A Dawson, Yan Yan, Marco P Monopoli

2015-02-01

The significance of a protein corona on nanoparticles in modulating particle properties and their biological interactions has been..

Versatile Loading of Diverse Cargo into Functional Polymer Capsules

Joseph J Richardson, James W Maina, Hirotaka Ejima, Ming Hu, Junling Guo, Mei Y Choy, Sylvia T Gunawan, Lien Lybaert, Christoph E Hagemeyer, Bruno G De Geest, Frank Caruso

2015-02-01

Polymer microcapsules are of particular interest for applications including self-healing coatings, catalysis, bioreactions, sensin..

The role of capsule stiffness on cellular processing

Huanli Sun, Edgar HH Wong, Yan Yan, Jiwei Cui, Qiong Dai, Junling Guo, Greg G Qiao, Frank Caruso

2015-01-01

Particle stiffness is emerging as an important parameter in determining the cell uptake dynamics of particles. Understanding the e..

Unravelling "off-target" effects of redox-active polymers and polymer multilayered capsules in prostate cancer cells

Giovanni L Beretta, Marco Folini, Francesca Cavalieri, Yan Yan, Enrico Fresch, Subramanian Kaliappan, Christoph Hasenhoerl, Joseph J Richardson, Stella Tinelli, Andreas Fery, Frank Caruso, Nadia Zaffaroni

2015-01-01

Redox-active polymers and carriers are oxidizing nanoagents that can potentially trigger intracellular off-target effects. In the ..