Cancer Genetics, Epigenetics And Targeted Therapies

Grant number: 1077867 | Funding period: 2015 - 2018

Completed

Abstract

I aim to gain greater insight into how blood cancers arise and how we should ultimately treat patients with these diseases. I will identify the genetic defects that underpin the development of blood cancers, how these genetic defects de-regulate gene expression through so-called “epigenetic” changes to allow these abnormal blood cells grow and survive. I will test the activity of small molecules that interfere with the cancer-causing epigenetic and signaling pathways in experimental models.