CONTROL OF ORGAN SIZE AND CANCER BY THE HIPPO PATHWAY
Grant number: 1078220 | Funding period: 2015 - 2020
The Hippo pathway is a key regulator of tissue growth. It was first discovered in vinegar flies and plays a similar role in mammals. We aim to define the mechanism by which the Hippo pathway controls tissue growth and cancer. These studies will be performed in flies and mammalian cell culture. Our studies will shed light on how tissue growth is controlled, and have the potential to inform the way that we treat human cancers and tissue growth disorders.
Related publications (15)
The Hippo pathway uses different machinery to control cell fate and organ size
Jonathan M Pojer, Samuel A Manning, Benjamin Kroeger, Shu Kondo, Kieran F Harvey
The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that ..
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven
Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..
Crumbs and the apical spectrin cytoskeleton regulate r8 cell fate in the Drosophila eye
Jonathan M Pojer, Abdul Jabbar Saiful Hilmi, Shu Kondo, Kieran F Harvey
The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanog..
TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex
Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas
Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective..
A PP2A-Integrator complex fine-tunes transcription by opposing CDK9
Stephin Vervoort, Sarah Welsh, Jennifer Devlin, Elisa Barbieri, Deborah Knight, Matteo Costacurta, Izabela Todorovski, Conor Kearney, Jarrod Sandow, Stefan Bjelosevic, Zheng Fan, Joep Vissers, Karolina Pavic, Ben Martin, Gareth Gregory, Isabella Kong, Edwin Hawkins, Simon Hogg, Madison Kelly, Andrea Newbold
<h4>SUMMARY</h4> Gene expression is tightly controlled by Cyclin-dependent kinases (CDKs) which regulate the RNA Polymerase II (RN..
The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis
Xiaomeng Zhang, Lie Yang, Pacman Szeto, Gamze Kuser Abali, Youfang Zhang, Aishwarya Kulkarni, Kaushalya Amarasinghe, Jason Li, Ismael A Vergara, Ramyar Molania, Anthony T Papenfuss, Catriona McLean, Mark Shackleton, Kieran F Harvey
Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younge..
Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi
Joseph HA Vissers, Lucas G Dent, Colin M House, Shu Kondo, Kieran F Harvey
The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis. In the..
Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila
Chun Hu, Alexandros K Kanellopoulos, Melanie Richter, Meike Petersen, Anja Konietzny, Federico M Tenedini, Nina Hoyer, Lin Cheng, Carole LC Poon, Kieran F Harvey, Sabine Windhorst, Jay Z Parrish, Marina Mikhaylova, Claudia Bagni, Froylan Calderon de Anda, Peter Soba
Dendritic arborization is highly regulated and requires tight control of dendritic growth, branching, cytoskeletal dynamics, and i..
Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma
Xiaomeng Zhang, Jian Zhong Tang, Ismael A Vergara, Youfang Zhang, Pacman Szeto, Lie Yang, Christopher Mintoff, Andrew Colebatch, Lachlan McIntosh, Katrina A Mitchell, Evangeline Shaw, Helen Rizos, Georgina Long, Nicholas Hayward, Grant A McArthur, Anthony T Papenfuss, Kieran F Harvey, Mark Shackleton
Melanoma is usually driven by mutations in BRAF or NRAS, which trigger hyperactivation of MAPK signaling. However, MAPK-targeted t..
The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development
Lucas G Dent, Samuel A Manning, Benjamin Kroeger, Audrey M Williams, Abdul Jabbar Saiful Hilmi, Luke Crea, Shu Kondo, Sally Horne-Badovinac, Kieran F Harvey
How biochemical and mechanical information are integrated during tissue development is a central question in morphogenesis. In man..
A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster
Carole LC Poon, Weijie Liu, Yanjun Song, Marta Gomez, Yavuz Kulaberoglu, Xiaomeng Zhang, Wenjian Xu, Alexey Veraksa, Alexander Hergovich, Amin Ghabrial, Kieran F Harvey
Hippo-like pathways are ancient signaling modules first identified in yeasts. The best-defined metazoan module forms the core of t..
The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate
Joseph HA Vissers, Francesca Froldi, Jan Schroder, Anthony T Papenfuss, Louise Y Cheng, Kieran F Harvey
The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scallo..
Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo
Samuel A Manning, Lucas G Dent, Shu Kondo, Ziqing W Zhao, Nicolas Plachta, Kieran F Harvey
The Hippo pathway is an evolutionarily conserved signaling network that integrates diverse cues to control organ size and cell fat..