Engineering Bioresponsive Hybrid Nanodevices using RNA, Peptides and Synthetic Polymers

The mechanical regulation of RNA binding protein hnRNPC in the failing heart

Fabiana Martino, Nandan Mysore Varadarajan, Ana Rubina Perestrelo, Vaclav Hejret, Helena Durikova, Dragana Vukic, Vladimir Horvath, Francesca Cavalieri, Frank Caruso, Waleed S Albihlal, Andre P Gerber, Mary A O'Connell, Stepanka Vanacova, Stefania Pagliari, Giancarlo Forte

2022-11-23

Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failu..

Transforming the Chemical Structure and Bio-Nano Activity of Doxorubicin by Ultrasound for Selective Killing of Cancer Cells

Sukhvir Kaur Bhangu, Soraia Fernandes, Giovanni Luca Beretta, Stella Tinelli, Marco Cassani, Agata Radziwon, Marcin Wojnilowicz, Sophia Sarpaki, Irinaios Pilatis, Nadia Zaffaroni, Giancarlo Forte, Frank Caruso, Muthupandian Ashokkumar, Francesca Cavalieri

2022-02-18

Reconfiguring the structure and selectivity of existing chemotherapeutics represents an opportunity for developing novel tumor-sel..

Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs

Agata Radziwon, Sukhvir K Bhangu, Soraia Fernandes, Christina Cortez-Jugo, Robert De Rose, Brendan Dyett, Marcin Wojnilowicz, Petra Laznickova, Jan Fric, Giancarlo Forte, Frank Caruso, Francesca Cavalieri

2022-01-24

Engineered nanoparticles for the encapsulation of bioactive agents hold promise to improve disease diagnosis, prevention and thera..

NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses

Federico Tidu, Marco De Zuani, Shyam Sushama Jose, Kamila Bendickova, Lukas Kubala, Frank Caruso, Francesca Cavalieri, Giancarlo Forte, Jan Fric

2021-06-25

Mesenchymal stromal cells (MSCs) combined with calcineurin-nuclear factor of activated T cell (CN-NFAT) inhibitors are being teste..

Dissecting the intracellular signalling and fate of a DNA nanosensor by super-resolution and quantitative microscopy.

Agata Glab, Alessandro Bertucci, Fabiana Martino, Marcin Wojnilowicz, Alessia Amodio, Mariano Venanzi, Francesco Ricci, Giancarlo Forte, Frank Caruso, Francesca Cavalieri

2020-07-13

DNA nanodevices have been developed as platforms for the manipulation of gene expression, delivery of molecular payloads, and dete..

Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles.

Pietro Pacchin Tomanin, Jiajing Zhou, Alessia Amodio, Rita Cimino, Agata Glab, Francesca Cavalieri, Frank Caruso

2020-06-14

Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many application..

Glycogen as a Building Block for Advanced Biological Materials

Quinn A Besford, Francesca Cavalieri, Frank Caruso

2020-05-07

Biological nanoparticles found in living systems possess distinct molecular architectures and diverse functions. Glycogen is a uni..

Synthesis of bio-functional nanoparticles from sono-responsive amino acids using high frequency ultrasound.

Sukhvir Kaur Bhangu, Muthupandian Ashokkumar, Francesca Cavalieri

2020-05-01

A simple, one-pot high frequency ultrasonication (490 kHz) methodology to convert hydrophobic and amphipathic amino acids into nan..

Sound-driven dissipative self-assembly of aromatic biomolecules into functional nanoparticles

Sukhvir Kaur Bhangu, Gianfranco Bocchinfuso, Muthupandian Ashokkumar, Francesca Cavalieri

2020-03-01

Dissipative self-assembly processes were recently exploited to assemble synthetic materials into supramolecular structures. In mos..

Modular Assembly of Host-Guest Metal-Phenolic Networks Using Macrocyclic Building Blocks

Shuaijun Pan, Rui Guo, Nadja Bertleff-Zieschang, Shanshan Li, Quinn A Besford, Qi-Zhi Zhong, Gyeongwon Yun, Yunti Zhang, Francesca Cavalieri, Yi Ju, Eirini Goudeli, Joseph J Richardson, Frank Caruso

2020-01-02

The manipulation of interfacial properties has broad implications for the development of high‐performance coatings. Metal–phenolic..

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

Marcin Wojnilowicz, Agata Glab, Alessandro Bertucci, Frank Caruso, Francesca Cavalieri

2019-01-01

The intracellular delivery of nucleic acids and proteins remains a key challenge in the development of biological therapeutics. In..

Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH

Pietro Pacchin Tomanin, Pavel V Cherepanov, Quinn A Besford, Andrew J Christofferson, Alessia Amodio, Chris F McConville, Irene Yarovsky, Frank Caruso, Francesca Cavalieri

2018-12-12

Nanostructured materials have potential as platforms for analytical assays and catalytic reactions. Herein, we report the synthesi..

Ultrasound-Assisted Synthesis of Cross-Linked Poly(ethylene glycol) Nanostructures with Hydrophobic Core and Hydrophilic Shell

Haiyan Zhu, Francesca Cavalieri, Muthupandian Ashokkumar

2018-12-01

One-pot synthesis of polymeric nanostructures, by using ultrasound without adding initiators and surfactants, is a straightforward..

Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

Quinn A Besford, Yi Ju, Ting-Yi Wang, Gyeongwon Yun, PavelV Cherepanov, Christoph E Hagemeyer, Francesca Cavalieri, Frank Caruso

2018-09-27

Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for..

Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids

Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri

2018-09-01

The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therape..

Sono-transformation of tannic acid into biofunctional ellagic acid micro/nanocrystals with distinct morphologies

Sukhvir Kaur Bhangu, Ritu Singla, Enrico Colombo, Muthupandian Ashokkumar, Francesca Cavalieri

2018-02-21

A sustainable, reagent-less and one-pot ultrasonic methodology has been developed to transform amorphous tannic acid into regularl..

Probing Transcription Factor Binding Activity and Downstream Gene Silencing in Living Cells with a DNA Nanoswitch

A Bertucci, J Guo, N Oppmann, A Glab, F Ricci, F Caruso, F Cavalieri

2018-01-28

Transcription factor DNA binding activity is of pivotal importance in living systems because of its primary involvement in the reg..

A Simple One-Step Ultrasonic Route To Synthesize Antioxidant Molecules and Fluorescent Nanoparticles from Phenol and Phenol Like Molecules

Sukhvir Kaur Bhangu, Muthupandian Ashokkumar, Francesca Cavalieri

2017-07-01

Fluorescent oligomeric structures were synthesized from the phenolic moieties by a simple one-step sonochemical approach without t..

Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release

Graziana Palmieri, Antonio Rinaldi, Luisa Campagnolo, Mariarosaria Tortora, Maria Federica Caso, Maurizio Mattei, Andrea Notargiacomo, Nicola Rosato, Massimo Bottini, Francesca Cavalieri

2017-06-01

A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a char..

Lactosylated Glycogen Nanoparticles for Targeting Prostate Cancer Cells

Quinn A Besford, Marcin Wojnilowicz, Tomoya Suma, Nadja Bertleff-Zieschang, Frank Caruso, Francesca Cayalieri

2017-05-24

Glyconanoparticles that exhibit multivalent binding to lectins are desirable for molecular recognition and therapeutic application..

Biofunctional metal-phenolic films from dietary flavonoids

Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso

2017-01-18

We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules,..

Sono-assembly of nanostructures via tyrosine-tyrosine coupling reactions at the interface of acoustic cavitation bubbles

Francesca Cavalieri, Enrico Colombo, Eleonora Nicolai, Nicola Rosato, Muthupandian Ashokkumar

2016-11-01

This work demonstrates that the reactive and oscillating surface of acoustic cavitation microbubbles acts as a catalytic binding s..

A combined approach for predicting the cytotoxic effect of drug-nanoaggregates

M Wojnilowicz, M Tortora, BG Bobay, E Santiso, M Caruso, L Micheli, M Venanzi, S Menegatti, F Cavalieri

2016-01-01

We present a combined spectroscopic and computational approach aimed to elucidate the mechanism of formation and activity of etopo..

Engineering Nanomedicines to Overcome Multidrug Resistance in Cancer Therapy

GL Berettab, F Cavalieri

2016-01-01

Drug resistance to conventional antitumor drugs still remains one of the major causes of treatment failure in patients affected by..

Probing cell internalisation mechanics with polymer capsules

Xi Chen, Jiwei Cui, Yuan Ping, Tomoya Suma, Francesca Cavalieri, Quinn A Besford, George Chen, Julia A Braunger, Frank Caruso

2016-01-01

We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(me..

Redox-Sensitive PEG-Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells

Francesca Cavalieri, Giovanni L Beretta, Jiwei Cui, Julia A Braunger, Yan Yan, Joseph J Richardson, Stella Tinelli, Marco Folini, Nadia Zaffaroni, Frank Caruso

2015-07-01

We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs)...