Alphaherpesvirus vaccination, recombination and latency; a study in the natural host

Grant number: FT140101287 | Funding period: 2015 - 2019

Completed

Abstract

Attenuated alphaherpesvirus vaccines are used widely in production and companion animals to help control disease. These vaccines help to prevent clinical signs of disease following challenge with virulent viruses. There is also the potential to use these vaccines to help prevent latent herpesvirus infections, and to limit the opportunities for herpesvirus recombination to occur. This would enhance the ability to control disease in animal populations. This project aims to systematically study how vaccines may be used to limit latency and recombination events by studying avian infectious laryngotracheitis virus in the natural host leading to new insights into how vaccines may be used more effi..

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Related publications (5)

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A high prevalence of beak and feather disease virus in non-psittacine Australian birds

Jemima Amery-Gale, Marc S Marenda, Jane Owens, Paul A Eden, Glenn F Browning, Joanne M Devlin

2017-07-01

PURPOSE: Beak and feather disease virus (BFDV) is a circovirus and the cause of psittacine beak and feather disease (PBFD). This d..

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Natural recombination in alphaherpesviruses: Insights into viral evolution through full genome sequencing and sequence analysis

Carlos A Loncoman, Paola K Vaz, Mauricio JC Coppo, Carol A Hartley, Francisco J Morera, Glenn F Browning, Joanne M Devlin

2017-04-01

Recombination in alphaherpesviruses was first described more than sixty years ago. Since then, different techniques have been used..

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Development and application of a TaqMan single nucleotide polymorphism genotyping assay to study infectious laryngotracheitis virus recombination in the natural host

Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Paola K Vaz, Andres Diaz-Mendez, Glenn F Browning, Sang-won Lee, Joanne M Devlin

2017-03-28

To date, recombination between different strains of the avian alphaherpesvirus infectious laryngotracheitis virus (ILTV) has only ..

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Impacts of poultry vaccination on viruses of wild bird

Joanne M Devlin, Paola K Vaz, Mauricio JC Coppo, Glenn F Browning

2016-08-01

Spillover of viruses from farmed poultry into wild birds is a relatively new area of study at the livestock-wildlife interface. Th..

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Evidence of widespread natural recombination among field isolates of equine herpesvirus 4 but not among field isolates of equine herpesvirus 1

PK Vaz, J Horsington, CA Hartley, GF Browning, NP Ficorilli, MJ Studdert, JR Gilkerson, JM Devlin

2016-03-01

Recombination in alphaherpesviruses allows evolution to occur in viruses that have an otherwise stable DNA genome with a low rate ..

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