P.falciparum var gene diversity and malaria control

Clinical malaria incidence following an outbreak in Ecuador was predominantly associated with Plasmodium falciparum with recombinant variant antigen gene repertoires

Shazia Ruybal-Pesántez, Fabian Sáenz, Samantha Deed, Erik Johnson, Daniel Larremore, Claudia Vera-Arias, Kathryn Tiedje, Karen Day

2021-04-15

To better understand the factors underlying the continued incidence of clinical episodes of falciparum malaria in E-2020 countries..

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Michael F Duffy, Sedigheh Zakeri, Tepanata Pumpaibool, Pongchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Thomas S Rask, Franck Prugnolle, Anthony T Papenfuss, Yao-ban Chan, Karen P Day

2021-02-01

Malaria remains a major public health problem in many countries. Unlike influenza and HIV, where diversity in immunodominant surfa..

Identifying functional groups among the diverse, recombining antigenic var genes of the malaria parasite Plasmodium falciparum from a local community in Ghana

Mary M Rorick, Edward B Baskerville, Thomas S Rask, Karen P Day, Mercedes Pascual

2018-06-01

A challenge in studying diverse multi-copy gene families is deciphering distinct functional types within immense sequence variatio..

Signatures of competition and strain structure within the major blood-stage antigen of Plasmodium falciparum in a local community in Ghana

Mary M Rorick, Yael Artzy-Randrup, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Thomas S Rask, Abraham Oduro, Anita Ghansah, Kwadwo Koram, Karen P Day, Mercedes Pascual

2018-04-01

The concept of niche partitioning has received considerable theoretical attention at the interface of ecology and evolution of inf..

A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages

Evelyn S Chou, Sabia Z Abidi, Marian Teye, Aleksandra Leliwa-Sytek, Thomas S Rask, Simon A Cobbold, Gerry Q Tonkin-Hill, Krishanthi S Subramaniam, Anna E Sexton, Darren J Creek, Johanna P Daily, Michael F Duffy, Karen P Day

2018-03-01

Transient regulation of Plasmodium numbers below the density that induces fever has been observed in chronic malaria infections in..

Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance

Virginie Rougeron, Kathryn E Tiedje, Donald S Chen, Thomas S Rask, Dionicia Gamboa, Amanda Maestre, Lise Musset, Eric Legrand, Oscar Noya, Erhan Yalcindag, Francois Renaud, Franck Prugnolle, Karen P Day

2017-11-01

Strong founder effects resulting from human migration out of Africa have led to geographic variation in single nucleotide polymorp..

Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda

Shazia Ruybal-Pesantez, Kathryn E Tiedje, Gerry Tonkin-Hill, Thomas S Rask, Moses R Kamya, Bryan Greenhouse, Grant Dorsey, Michael F Duffy, Karen P Day

2017-09-18

Plasmodium falciparum causes a spectrum of malarial disease from asymptomatic to uncomplicated through to severe. Investigations o..

Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa

Karen P Day, Yael Artzy-Randrup, Kathryn E Tiedje, Virginie Rougeron, Donald S Chen, Thomas S Rask, Mary M Rorick, Florence Migot-Nabias, Philippe Deloron, Adrian JF Luty, Mercedes Pascual

2017-05-16

Existing theory on competition for hosts between pathogen strains has proposed that immune selection can lead to the maintenance o..

Using expected sequence features to improve basecalling accuracy of amplicon pyrosequencing data

Thomas S Rask, Bent Petersen, Donald S Chen, Karen P Day, Anders Gorm Pedersen

2016-04-22

BACKGROUND: Amplicon pyrosequencing targets a known genetic region and thus inherently produces reads highly anticipated to have c..

Hypervariable antigen genes in malaria have ancient roots

Martine M Zilversmit, Ella K Chase, Donald S Chen, Philip Awadalla, Karen P Day, Gil McVean

2013-05-31

BACKGROUND: The var genes of the human malaria parasite Plasmodium falciparum are highly polymorphic loci coding for the erythrocy..

Epistatic Interactions between Apolipoprotein E and Hemoglobin S Genes in Regulation of Malaria Parasitemia

V Rougeron, CM Woods, KE Tiedje, F Bodeau-Livinec, F Migot-Nabias, P Deloron, AJF Luty, FJI Fowkes, KP Day

2013-01-01

Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglyce..

A Molecular Epidemiological Study of var Gene Diversity to Characterize the Reservoir of Plasmodium falciparum in Humans in Africa

Donald S Chen, Alyssa E Barry, Aleksandra Leliwa-Sytek, Terry-Ann Smith, Ingrid Peterson, Stuart M Brown, Florence Migot-Nabias, Philippe Deloron, Moses M Kortok, Kevin Marsh, Johanna P Daily, Daouda Ndiaye, Ousmane Sarr, Souleymane Mboup, Karen P Day

2011-02-09

BACKGROUND: The reservoir of Plasmodium infection in humans has traditionally been defined by blood slide positivity. This study w..