GENE-ENVIRONMENT INTERACTIONS MODULATING COGNITION AND DEMENTIA IN HUNTINGTON’S DISEASE
Grant number: 1085977 | Funding period: 2015 - 2017
We are investigating mechanisms whereby cognitive symptoms, culminating in dementia, occur in a fatal brain disease, Huntington’s. We will explore how the ‘genetic stutter’ affects the brain at the level of molecules and cells, which will help identify targets for future treatment. We will also establish how environmental factors, including cognitive stimulation, physical activity and stress, modulate dementia. This will inform the development of treatments for this currently incurable disease.
Related publications (2)
Short-Term Environmental Stimulation Spatiotemporally Modulates Specific Serotonin Receptor Gene Expression and Behavioral Pharmacology in a Sexually Dimorphic Manner in Huntington's Disease Transgenic Mice
Michelle S Zajac, Thibault Renoir, Victoria M Perreau, Shanshan Li, Wendy Adams, Maarten van den Buuse, Anthony J Hannan
Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tr..
What's wrong with my mouse cage? Methodological considerations for modeling lifestyle factors and gene-environment interactions in mice
Christina Mo, Thibault Renoir, Anthony J Hannan
The mechanistic understanding of lifestyle contributions to disease has been largely driven by work in laboratory rodent models us..