HOST METABOLISM AND RESPONSES CONTRIBUTING TO FLAVIVIRUS REPLICATION AND PATHOGENESIS
Grant number: 1081786 | Funding period: 2015 - 2017
We aim to determine how viruses affect the cells they infect, In particular how they can alter the metabolism and balance of lipids in cells and how this impacts the bodies capability to respond immunologically. We believe that by understanding these basic principles we can target ares fr antiviral therapeutic potential.
Related publications (2)
Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus
Susann Liebscher, Rebecca L Ambrose, Turgut E Aktepe, Andrea Mikulasova, Julia E Prier, Leah K Gillespie, Adam J Lopez-Denman, Thusitha WT Rupasinghe, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie
Positive-sense RNA virus intracellular replication is intimately associated with membrane platforms that are derived from host org..
The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling
Turgut E Aktepe, Susann Liebscher, Julia E Prier, Cameron P Simmons, Jason M Mackenzie
Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and ..