NEURAL REGULATION OF T CELL FUNCTIONS
Grant number: 1082450 | Funding period: 2015 - 2017
Immune responses to pathogens are generated in lymphoid tissues that are innervated by the sympathetic nervous system, which functions during times of stress or infection. Very little is known about the impact of the sympathetic nervous system on immune cell functions during responses to pathogens. This project will test the hypothesis that nervous signals can influence lymphocyte behaviour and that pharmaceutical intervention could augment immunity to infections.
Related publications (1)
Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses.
Sapna Devi, Yannick O Alexandre, Joon Keit Loi, Ryan Gillis, Nazanin Ghazanfari, Sarah J Creed, Lauren E Holz, David Shackleford, Laura K Mackay, William R Heath, Erica K Sloan, Scott N Mueller
The sympathetic nervous system (SNS) controls various physiological functions via the neurotransmitter noradrenaline. Activation o..