THE FUNCTIONAL INTERPLAY BETWEEN ALPHA SYNUCLEIN AND SYNAPTOPHYSIN IN SYNAPTIC VESICLE RECYCLING
Grant number: 1085483 | Funding period: 2015 - 2019
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, affecting 7 million people worldwide. ?-synuclein is a protein in that brain that is likely to contribute to the death of brain cells in PD, but the normal role of the protein remains unknown. This study will investigate the function of ?-synuclein in maintaining normal healthy brain activity. In addition, this work will help us understand the processes that go awry in neurodegenerative disease states such as PD.
Related publications (6)
Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels.
Alexandros C Kokotos, Callista B Harper, Jamie RK Marland, Karen J Smillie, Michael A Cousin, Sarah L Gordon
The two most abundant molecules on synaptic vesicles (SVs) are synaptophysin and synaptobrevin-II (sybII). SybII is essential for ..
L-3,4-dihydroxyphenylalanine (L-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease
Jessica L Billings, Sarah L Gordon, Tristan Rawling, Philip A Doble, Ashley I Bush, Paul A Adlard, David I Finkelstein, Dominic J Hare
Treatment with the dopamine (DA) precursor l-3,4-dihydroxyphenylalanine (l-DOPA) provides symptomatic relief arising from DA dener..
A Fine Balance of Synaptophysin Levels Underlies Efficient Retrieval of Synaptobrevin II to Synaptic Vesicles.
Sarah L Gordon, Callista B Harper, Karen J Smillie, Michael A Cousin
Synaptobrevin II (sybII) is a vesicular soluble NSF attachment protein receptor (SNARE) protein that is essential for neurotransmi..