PREDICTING TREATMENT RESPONSE TO ONABOTULINUMTOXIN-A IN MS-RELATED TREMOR: A COMBINED CLINICAL, ELECTROPHYSIOLOGICAL AND NEUROIMAGING APPROACH.

Grant number: 1085461 | Funding period: 2015 - 2018

Completed

Abstract

Shaking (tremor) of the upper limbs occur in many people with multiple sclerosis (MS). We have previously shown that botulinum toxin (Botox) injections could help reduce tremor. This study aims to study the effect of Botox in a larger group of people with MS and will include detailed MRI scans and electrical tremor monitoring tests to define the underlying changes in the brain that causes tremor. The results will help make Botox available as a tremor treatment for people with MS.

Related publications (8)

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Quantifying the impact of upper limb tremor on the quality of life of people with multiple sclerosis: a comparison between the QUEST and MSIS-29 scales

Chi-Chang Tang, Sze-Ee Soh, Frederique Boonstra, Gustavo Noffs, Scott C Kolbe, Helmut Butzkueven, Andrew Evans, Anneke Van der Walt

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BACKGROUND: Upper limb tremor is common in people with multiple sclerosis (pwMS) and can affect day to day function, impacting on ..

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Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis

G Noffs, FMC Boonstra, T Perera, H Butzkueven, SC Kolbe, F Maldonado, LE Cofre Lizama, MP Galea, J Stankovich, A Evans, A van Der Walt, AP Vogel

2020-10-22

BACKGROUND AND PURPOSE: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis..

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Acoustic Speech Analytics Are Predictive of Cerebellar Dysfunction in Multiple Sclerosis

Gustavo Noffs, Frederique MC Boonstra, Thushara Perera, Scott C Kolbe, Jim Stankovich, Helmut Butzkueven, Andrew Evans, Adam P Vogel, Anneke van der Walt

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Speech production relies on motor control and cognitive processing and is linked to cerebellar function. In diseases where the cer..

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Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis.

Frederique Mc Boonstra, Gustavo Noffs, Thushara Perera, Vilija G Jokubaitis, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Andrew Evans, Anneke van der Walt, Scott C Kolbe

2020-05-01

BACKGROUND: Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology..

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OnabotulinumtoxinA treatment for MS-tremor modifies fMRI tremor response in central sensory-motor integration areas

Frederique MC Boonstra, Andrew Evans, Gustavo Noffs, Thushara Perera, Vilija Jokubaitis, Jim Stankovich, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Scott C Kolbe, Anneke van der Walt

2020-05-01

BACKGROUND: Treatment of tremor in MS is an unmet need. OnabotulinumtoxinA (BoNT-A) has shown promising results; however, little i..

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Validation of a precision tremor measurement system for multiple sclerosis

Thushara Perera, Wee-Lih Lee, Shivanthan AC Yohanandan, Nguyen Ai-Lan, Belinda Cruse, Frederique MC Boonstra, Gustavo Noffs, Adam P Vogel, Scott C Kolbe, Helmut Butzkueven, Andrew Evans, Anneke van der Walt

2019-01-01

BACKGROUND: Tremor is a debilitating symptom of Multiple Sclerosis (MS). Little is known about its pathophysiology and treatments ..

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What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

Gustavo Noffs, Thushara Perera, Scott C Kolbe, Camille J Shanahan, Frederique MC Boonstra, Andrew Evans, Helmut Butzkueven, Anneke van der Walt, Adam P Vogel

2018-12-01

IMPORTANCE: Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is fr..

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Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor

Frederique MC Boonstra, Thushara Perera, Gustavo Noffs, Cassandra Marotta, Adam P Vogel, Andrew H Evans, Helmut Butzkueven, Bradford A Moffat, Anneke van der Walt, Scott C Kolbe

2018-07-02

Introduction: Tremor of the upper limbs is a disabling symptom that is present during several neurological disorders and is curren..

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