PREDICTING TREATMENT RESPONSE TO ONABOTULINUMTOXIN-A IN MS-RELATED TREMOR: A COMBINED CLINICAL, ELECTROPHYSIOLOGICAL AND NEUROIMAGING APPROACH.
Grant number: 1085461 | Funding period: 2015 - 2018
Shaking (tremor) of the upper limbs occur in many people with multiple sclerosis (MS). We have previously shown that botulinum toxin (Botox) injections could help reduce tremor. This study aims to study the effect of Botox in a larger group of people with MS and will include detailed MRI scans and electrical tremor monitoring tests to define the underlying changes in the brain that causes tremor. The results will help make Botox available as a tremor treatment for people with MS.
Related publications (6)
Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis
G Noffs, FMC Boonstra, T Perera, H Butzkueven, SC Kolbe, F Maldonado, LE Cofre Lizama, MP Galea, J Stankovich, A Evans, A van Der Walt, AP Vogel
BACKGROUND AND PURPOSE: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis..
Acoustic Speech Analytics Are Predictive of Cerebellar Dysfunction in Multiple Sclerosis
Gustavo Noffs, Frederique MC Boonstra, Thushara Perera, Scott C Kolbe, Jim Stankovich, Helmut Butzkueven, Andrew Evans, Adam P Vogel, Anneke van der Walt
Speech production relies on motor control and cognitive processing and is linked to cerebellar function. In diseases where the cer..
OnabotulinumtoxinA treatment for MS-tremor modifies fMRI tremor response in central sensory-motor integration areas
Frederique MC Boonstra, Andrew Evans, Gustavo Noffs, Thushara Perera, Vilija Jokubaitis, Jim Stankovich, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Scott C Kolbe, Anneke van der Walt
BACKGROUND: Treatment of tremor in MS is an unmet need. OnabotulinumtoxinA (BoNT-A) has shown promising results; however, little i..
Validation of a precision tremor measurement system for multiple sclerosis
Thushara Perera, Wee-Lih Lee, Shivanthan AC Yohanandan, Nguyen Ai-Lan, Belinda Cruse, Frederique MC Boonstra, Gustavo Noffs, Adam P Vogel, Scott C Kolbe, Helmut Butzkueven, Andrew Evans, Anneke van der Walt
BACKGROUND: Tremor is a debilitating symptom of Multiple Sclerosis (MS). Little is known about its pathophysiology and treatments ..
What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis
Gustavo Noffs, Thushara Perera, Scott C Kolbe, Camille J Shanahan, Frederique MC Boonstra, Andrew Evans, Helmut Butzkueven, Anneke van der Walt, Adam P Vogel
IMPORTANCE: Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is fr..
Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor
Frederique MC Boonstra, Thushara Perera, Gustavo Noffs, Cassandra Marotta, Adam P Vogel, Andrew H Evans, Helmut Butzkueven, Bradford A Moffat, Anneke van der Walt, Scott C Kolbe
Introduction: Tremor of the upper limbs is a disabling symptom that is present during several neurological disorders and is curren..